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[H1] Keep moving forward with ADCIRCA®(tadalafil)
Can help improve your exercise ability with a once-daily treatment for pulmonary arterial hypertension (PAH)About Adcirca
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For US Residents Only
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For US Residents Only
[H2] The Once-Daily PAH Treatment
ADCIRCA (pronounced AD-SUR-KUH) is a prescription medicine called a phosphodiesterase 5 inhibitor (PDE-5i) used to treat pulmonary arterial hypertension (PAH, high blood pressure in your lungs) to improve exercise ability.Patients taking ADCIRCA increased their 6-minute walk distance by an average of 33 meters (108 feet) after 16 weeks of treatment.Learn More
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Learn More
[H2] What is PAH?
PAH is high blood pressure in the blood vessels of the lungs, which is different than ordinary high blood pressure that can occur throughout the body.What is PAHNeed support with your PAH treatment? United Therapeutics Cares™ can help!Support & Cost AssistanceFAQsFor answers to common questions about ADCIRCAWhat are the possible benefits of taking ADCIRCA?ADCIRCA may improve exercise ability. In the large clinical study for ADCIRCA, after 16 weeks of treatment, patients taking ADCIRCA increased their 6-minute walk distance (6MWD), or the distance they were able to walk in 6 minutes, by an average of 33 meters, or 108 feet.What are the most common side effects of ADCIRCA?The most common side effects of ADCIRCA are headache, muscle pain, getting red or hot in the face (flushing), nausea, pain in the arms, legs or back, upset stomach, and stuffy or congested nose.These are not all the possible side effects of ADCIRCA. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.What are the ingredients in ADCIRCA?ADCIRCA contains tadalafil, the same main ingredient in Cialis®:Active ingredient: tadalafilInactive ingredients: croscarmellose sodium, hydroxypropyl cellulose, hypromellose, iron oxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, talc, titanium dioxide, and triacetinView All FAQs
[H2] Resources
Here you will find additional resources on pulmonary arterial hypertension (PAH), including PAH organizations and community groups, and downloadable resources to support your treatment with ADCIRCA.CommunityPatient InformationCost Assistance

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[H1] About PAH
[IMG: About PAH]
[H2] What is PAH?
PAH is high blood pressure in the blood vessels of the lungs, which is different than ordinary high blood pressure that can occur throughout the body. In PAH, the blood vessels in the lungs become narrow and stiff creating more pressure and making it more difficult for blood to flow through these arteries, which means the heart has to pump harder to push blood through them
[H2] Common Symptoms
The most common signs and symptoms of PAH include:Dizziness and/or faintingShortness of breathChest painFeeling tired or worn outSwollen ankles or legsSwollen abdomenRapid, hard, or irregular heartbeats
[IMG: Common symptoms of PAH]
How does PAH affect the body?In PAH, high blood pressure in the blood vessels of the lungs affects the ability of the heart and lungs to work properly. Here is how the blood vessels, lungs, and heart function normally compared with those affected by PAH.Loading tabs...Diagnosing PAHThe symptoms of PAH are similar to the symptoms of other, more common diseases, such as asthma or other lung diseases, and various heart diseases. If you think you are experiencing symptoms of PAH, talk to your healthcare provider.To diagnose PAH, your healthcare provider will need to obtain a thorough medical history, a physical exam, and results from certain tests and procedures.Loading Cards...Confirmation Test
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Right-heart catheterizationIf the preliminary tests suggest PAH, a right-heart catheterization will be done to confirm the diagnosis and to assess how severe the PAH is.Right-heart catheterization involves inserting a long, thin, flexible tube called a catheter through the blood vessels and into the heart. This procedure allows your healthcare provider to test heart function and blood pressure in the heart and lungs.This is the only test that can absolutely confirm a PAH diagnosis, and it will only be performed if the preliminary tests have shown results that suggest PAH.Need support with your PAH treatment? United Therapeutics Cares™ can help!Support & Cost AssistanceResourcesHere you will find additional resources on pulmonary arterial hypertension (PAH), including PAH organizations and community groups, and downloadable resources to support your treatment with ADCIRCA.CommunityPatient InformationCost Assistance

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[H1] Resources & Support
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[H2] ADCIRCA® (tadalafil) Cost Assistance
Once your benefits have been verified, if you need financial assistance, you may qualify for one of the programs offered by United Therapeutics. Notify your Specialty Pharmacy (SP) when scheduling shipment or contact United Therapeutics Cares directly.Call United Therapeutics Cares at 1-844-864-8437 to find out if you qualify for financial support or visit UnitedTherapeuticsCares.com.Terms and Conditions*Patients must meet certain eligibility criteria to qualify for assistance. Patients receiving reimbursement under Medicare, Medicaid, VA, DoD (TRICARE), Indian Health Services, or similar federal or state programs, may not be eligible for some assistance. Cannot be combined with any other offer, discount, rebate or coupon. Some portion of this patient assistance may be administered by third-party patient assistance organizations. The Program is subject to additional state law restrictions. Patients residing in select states may not be eligible for the Program. Not available for Massachusetts residents, and certain restrictions apply for California residents.
[H3] Co-Pay Assistance Card
For patients with commercial or private insurance plan, we offer a co-pay assistance card to help save on some of your out-of-pocket costs if you are eligible.Most eligible patients with commercial/private insurance plans may pay as little as a $0 co-pay for each prescription of ADCIRCA up to the monthly benefit of $800.
[H3] Patient Assistance Program (PAP)
United Therapeutics offers a free medication program for uninsured and underinsured patients who meet eligibility requirements.Terms and Conditions*Patients must meet certain eligibility criteria to qualify for assistance. Patients receiving reimbursement under Medicare, Medicaid, VA, DoD (TRICARE), Indian Health Services, or similar federal or state programs, may not be eligible for some assistance. Cannot be combined with any other offer, discount, rebate or coupon. Some portion of this patient assistance may be administered by third-party patient assistance organizations. The Program is subject to additional state law restrictions. Patients residing in select states may not be eligible for the Program. Not available for Massachusetts residents, and certain restrictions apply for California residents.Patient InformationThis document includes some of the most important information you should know about ADCIRCA, how to take ADCIRCA properly, common side effects, and more.Download Patient Information
[H2] PAH Organizations
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Pulmonary Hypertension Association (PHA)phassociation.orgPHA's mission is to find ways to prevent and cure pulmonary hypertension, and to provide hope for the pulmonary hypertension community through support, education, advocacy, and awareness.
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National Heart, Lung, and Blood Institute (NHLBI)nhlbi.nih.govThe NHLBI provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases, and to enhance the health of all individuals so they can live longer and more fulfilling lives.
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Scleroderma Foundation (SF)scleroderma.orgSF is a nonprofit organization whose mission is to help patients with scleroderma to cope with scleroderma through education, research, and support. This Web site may be a useful resource for people with PAH associated with scleroderma.
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PAH Initiativewww.pahinitiative.comThe PAH Initiative is dedicated to advancing patient care in pulmonary arterial hypertension (PAH). They can help you better understand what's happening, why it's happening, and what you and your healthcare provider can do about it.FAQsFor answers to common questions about ADCIRCALoading tabs...

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[H1] About ADCIRCA®(tadalafil)
[IMG: About PAH]
[H2] What is ADCIRCA® (tadalafil)?
ADCIRCA (pronounced AD-SUR-KUH) is a prescription medicine called a phosphodiesterase 5 inhibitor (PDE-5i) used to treat pulmonary arterial hypertension (PAH, high blood pressure in your lungs) to improve exercise ability.After 16 weeks of treatment, patients taking ADCIRCA increased their 6-minute walk distance (6MWD) by an average of 33 meters, or 108 feet compared to patients taking placebo (sugar pill)ADCIRCA is the only PDE-5i for PAH taken once-dailyIt is not known if ADCIRCA is safe or effective in children
[IMG: Illustration of a Healthy Blood Vessel]
Healthy blood vessels
[IMG: Illustration of a PAH-Affected Blood Vessel]
PAH-affected blood vessels
[H2] How it Works
ADCIRCA treats PAH by increasing the amount of a natural substance in your blood vessels, which helps widen them. When the vessels are widened, blood can flow more easily through your lungs, where it picks up oxygen.As a result, your blood can better carry oxygen to the rest of your body. The heart and lungs no longer have to work as hard, which improves your ability to exercise.How ADCIRCA® (tadalafil) may help youADCIRCA was shown to improve exercise ability in patients with PAH in a large 16-week clinical study. Patients taking ADCIRCA:Increased their 6-minute walk distance (6MWD) after 16 weeks of treatment by an average of 33 meters, or 108 feet compared to patients taking a placebo (sugar pill).Experienced less clinical worsening* than patients taking a placebo.This study included mainly patients with NYHA Functional Class II–III symptoms who had idiopathic PAH (PAH of an unknown cause) or heritable PAH (a family history of PAH) (61% of patients), or PAH associated with connective tissue diseases (23%), such as scleroderma*Clinical worsening is defined as death, lung transplantation, atrial septostomy, hospitalization because of worsening PAH, initiation of new PAH therapy, or worsening of NYHA functional class.Improve exercise abilityIncrease 6 minute walk distanceLessen clinical worseningADCIRCA® (tadalafil) Most Common Side EffectsHeadacheMuscle painGetting red or hot in the face (flushing)Pain in the arms, legs or backNausea or upset stomachStuffy or congested noseThese are not all the possible side effects of ADCIRCA. For more information about ADCIRCA, please see the Full Prescribing Information and Patient Information. You can also ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.FAQsFor answers to common questions about ADCIRCAWhat is the most important information I should know about ADCIRCA?Never take ADCIRCA with any nitrate medicine or guanylate cyclase stimulator:Your blood pressure could drop quickly to an unsafe levelYou could get dizzy, faint, or even have a heart attack or strokeNitrates include:Medicines that treat chest pain (angina)Nitroglycerin in any form, including tablets, patches, sprays, and ointmentsOther nitrate medicines (isosorbide mononitrate or dinitrate)Recreational drugs that are inhaled, called “poppers” (amyl nitrate, butyl nitrate, or butyl nitrite)Guanylate cyclase stimulators include:Riociguat (Adempas®) a medicine that treats pulmonary arterial hypertension and chronicthromboembolic pulmonary hypertensionAsk your healthcare provider or pharmacist if you are not sure whether you take a nitrate medicine or guanylate cyclase stimulator medicine.What are the possible benefits of taking ADCIRCA?ADCIRCA may improve exercise ability. In the large clinical study for ADCIRCA, after 16 weeks of treatment, patients taking ADCIRCA increased their 6-minute walk distance (6MWD), or the distance they were able to walk in 6 minutes, by an average of 33 meters, or 108 feet.What types of PAH patients were included in the studies for ADCIRCA?Studies establishing effectiveness included predominately patients with NYHA Functional Class II–III symptoms and etiologies of idiopathic PAH (PAH of an unknown cause) or heritable PAH (a family history of PAH) (61%) or PAH associated with connective tissue diseases (23%).View All FAQs Need support with your PAH treatment? United Therapeutics Cares™ can help!Support & Cost AssistanceResourcesHere you will find additional resources on pulmonary arterial hypertension (PAH), including PAH organizations and community groups, and downloadable resources to support your treatment with ADCIRCA.CommunityPatient InformationCost Assistance