Training Example: Genentech – Review the Data, Give Your Score & Compare to the Real AI Evaluation

[IMG: Metastatic Colorectal Cancer (mCRC) treatment option]

[IMG: Out-of-Pocket Support]

[H2] OUT-OF-POCKET SUPPORT
up to $25,000 per calendar year
The Genentech Oncology Co-pay Assistance Program can help you with the out-of-pocket costs for Avastin, if you’re eligible. Let us help you understand your financial assistance options.

Get Support

[IMG: How Avastin® (bevacizumab) is designed to work]

[H2] FIND OUT HOW AVASTIN IS DESIGNED TO WORK
Avastin is a tumor-starving therapy. Read more about how it's designed to work.

Learn More

[IMG: Avastin® (bevacizumab) Patient Resources]

[H2] PATIENT RESOURCES
Find helpful information and support.

Get Answers

[IMG: Learn about side effects]

Get answers on the possible side effects of Avastin therapy.

Learn more

[IMG: Avastin® (bevacizumab) Caregiver Tips]

Read about being a caregiver and find resources.

Learn more

*Eligibility criteria and annual limits apply. Not valid for patients using federal or state government programs to pay for their medications. Patients must be taking AVASTIN for an FDA-approved indication. See full TERMS AND CONDITIONS.

Avastin® (bevacizumab) is a biologic medicine designed to target and inhibit vascular endothelial growth factor (VEGF), a key protein that stimulates new blood vessel growth in tumors. By blocking VEGF, Avastin helps starve tumors of the blood and oxygen they need to grow, slowing disease progression in people with metastatic colorectal cancer (mCRC).
Avastin is given as an intravenous (IV) infusion in combination with chemotherapy, typically every 2 to 3 weeks depending on your prescribed treatment plan. Treatment continues as long as your healthcare provider determines you are benefiting.
Serious side effects include: GI perforation, a hole that develops in your stomach or intestine, abnormal passage in the body, wounds that don't heal, serious bleeding, severe high blood pressure, kidney problems, infusion-related reactions, severe stroke or heart problems, and nervous system and vision problems. Common side effects are high blood pressure, too much protein in the urine, nosebleeds, bleeding, back pain, headache, taste change, dry skin, Inflammation of the skin and nose, and watery eyes. It’s important to review benefits and risks with your doctor.

[H4]
Important Safety Information & Indication

Back to Top

[H3] Indication
[H5] Metastatic Colorectal Cancer (mCRC)
Avastin is approved to treat metastatic colorectal cancer (mCRC) for:
First- or second-line treatment in combination with intravenous fluorouracil–based chemotherapy
Second-line treatment when used with fluoropyrimidine-based (combined with irinotecan or oxaliplatin) chemotherapy after cancer progresses following a first-line treatment containing bevacizumab
Avastin is not approved for use after surgery was used as the primary treatment in patients with colon cancer which has not spread to other parts of the body.

[H3] Possible serious side effects
Everyone reacts differently to Avastin therapy. So, it's important to know what the side effects are. Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if there are any signs of these side effects.
GI perforation. A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever
Abnormal passage in the body. This type of passage—known as a fistula—is an irregular connection from one part of the body to another and can sometimes be fatal
Wounds that don't heal. A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
Serious bleeding. This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor
Severe high blood pressure. Blood pressure that severely spikes or shows signs of affecting the brain. Blood pressure should be monitored every 2 to 3 weeks while on Avastin and after stopping treatment
Kidney problems. These may be caused by too much protein in the urine and can sometimes be fatal
Infusion-related reactions. These were uncommon with the first dose (less than 3% of patients). 0.4% of patients had severe reactions. Infusion-related reactions include high blood pressure or severe high blood pressure that may lead to stroke, trouble breathing, decreased oxygen in red blood cells, serious allergic reactions, chest pain, headache, tremors, and excessive sweating. Your doctor or nurse will monitor you for signs of infusion-related reactions
Severe stroke or heart problems. These may include blood clots, mini-stroke, heart attack, chest pain, and your heart may become too weak to pump blood to other parts of your body (congestive heart failure). These can sometimes be fatal
Nervous system and vision problems. Signs include headache, seizure, high blood pressure, sluggishness, confusion, and blindness

[H3] Side effects seen most often
In clinical studies across different types of cancer, some patients experienced the following side effects:
High blood pressure
Too much protein in the urine
Nosebleeds
Bleeding
Back pain
Headache
Taste change
Dry skin
Inflammation of the skin
Inflammation of the nose
Watery eyes

[H3] Avastin is not for everyone
Talk to your doctor if you are:
Undergoing surgery. Avastin should not be used for 28 days before or after surgery and until surgical wounds are fully healed
Pregnant or think you are pregnant. Data have shown that Avastin may harm your unborn baby. Use birth control while on Avastin. If you stop Avastin, you should keep using birth control for 6 months before trying to become pregnant
Planning to become pregnant. Taking Avastin could cause a woman’s ovaries to stop working and may impair her ability to have children
Breastfeeding. Breastfeeding while on Avastin may harm your baby, therefore, women should not breastfeed during and for 6 months after taking Avastin
For more information about your treatment or condition, talk to your doctor.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see full Product Information for additional important safety information.

[IMG: Metastatic Colorectal Cancer (mCRC) treatment option]

[IMG: Out-of-Pocket Support]

[H2] OUT-OF-POCKET SUPPORT
up to $25,000 per calendar year
The Genentech Oncology Co-pay Assistance Program can help you with the out-of-pocket costs for Avastin, if you’re eligible. Let us help you understand your financial assistance options.

Get Support

[IMG: How Avastin® (bevacizumab) is designed to work]

[H2] FIND OUT HOW AVASTIN IS DESIGNED TO WORK
Avastin is a tumor-starving therapy. Read more about how it's designed to work.

Learn More

[IMG: Avastin® (bevacizumab) Patient Resources]

[H2] PATIENT RESOURCES
Find helpful information and support.

Get Answers

[IMG: Learn about side effects]

Get answers on the possible side effects of Avastin therapy.

Learn more

[IMG: Avastin® (bevacizumab) Caregiver Tips]

Read about being a caregiver and find resources.

Learn more

*Eligibility criteria and annual limits apply. Not valid for patients using federal or state government programs to pay for their medications. Patients must be taking AVASTIN for an FDA-approved indication. See full TERMS AND CONDITIONS.

Avastin® (bevacizumab) is a biologic medicine designed to target and inhibit vascular endothelial growth factor (VEGF), a key protein that stimulates new blood vessel growth in tumors. By blocking VEGF, Avastin helps starve tumors of the blood and oxygen they need to grow, slowing disease progression in people with metastatic colorectal cancer (mCRC).
Avastin is given as an intravenous (IV) infusion in combination with chemotherapy, typically every 2 to 3 weeks depending on your prescribed treatment plan. Treatment continues as long as your healthcare provider determines you are benefiting.
Serious side effects include: GI perforation, a hole that develops in your stomach or intestine, abnormal passage in the body, wounds that don't heal, serious bleeding, severe high blood pressure, kidney problems, infusion-related reactions, severe stroke or heart problems, and nervous system and vision problems. Common side effects are high blood pressure, too much protein in the urine, nosebleeds, bleeding, back pain, headache, taste change, dry skin, Inflammation of the skin and nose, and watery eyes. It’s important to review benefits and risks with your doctor.

[H4]
Important Safety Information & Indication

Back to Top

[H3] Indication
[H5] Metastatic Colorectal Cancer (mCRC)
Avastin is approved to treat metastatic colorectal cancer (mCRC) for:
First- or second-line treatment in combination with intravenous fluorouracil–based chemotherapy
Second-line treatment when used with fluoropyrimidine-based (combined with irinotecan or oxaliplatin) chemotherapy after cancer progresses following a first-line treatment containing bevacizumab
Avastin is not approved for use after surgery was used as the primary treatment in patients with colon cancer which has not spread to other parts of the body.

[H3] Possible serious side effects
Everyone reacts differently to Avastin therapy. So, it's important to know what the side effects are. Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if there are any signs of these side effects.
GI perforation. A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever
Abnormal passage in the body. This type of passage—known as a fistula—is an irregular connection from one part of the body to another and can sometimes be fatal
Wounds that don't heal. A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
Serious bleeding. This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor
Severe high blood pressure. Blood pressure that severely spikes or shows signs of affecting the brain. Blood pressure should be monitored every 2 to 3 weeks while on Avastin and after stopping treatment
Kidney problems. These may be caused by too much protein in the urine and can sometimes be fatal
Infusion-related reactions. These were uncommon with the first dose (less than 3% of patients). 0.4% of patients had severe reactions. Infusion-related reactions include high blood pressure or severe high blood pressure that may lead to stroke, trouble breathing, decreased oxygen in red blood cells, serious allergic reactions, chest pain, headache, tremors, and excessive sweating. Your doctor or nurse will monitor you for signs of infusion-related reactions
Severe stroke or heart problems. These may include blood clots, mini-stroke, heart attack, chest pain, and your heart may become too weak to pump blood to other parts of your body (congestive heart failure). These can sometimes be fatal
Nervous system and vision problems. Signs include headache, seizure, high blood pressure, sluggishness, confusion, and blindness

[H3] Side effects seen most often
In clinical studies across different types of cancer, some patients experienced the following side effects:
High blood pressure
Too much protein in the urine
Nosebleeds
Bleeding
Back pain
Headache
Taste change
Dry skin
Inflammation of the skin
Inflammation of the nose
Watery eyes

[H3] Avastin is not for everyone
Talk to your doctor if you are:
Undergoing surgery. Avastin should not be used for 28 days before or after surgery and until surgical wounds are fully healed
Pregnant or think you are pregnant. Data have shown that Avastin may harm your unborn baby. Use birth control while on Avastin. If you stop Avastin, you should keep using birth control for 6 months before trying to become pregnant
Planning to become pregnant. Taking Avastin could cause a woman’s ovaries to stop working and may impair her ability to have children
Breastfeeding. Breastfeeding while on Avastin may harm your baby, therefore, women should not breastfeed during and for 6 months after taking Avastin
For more information about your treatment or condition, talk to your doctor.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see full Product Information for additional important safety information.

[H1] How is Avastin designed to work?

Avastin® (bevacizumab) is a tumor-starving (anti-angiogenic) therapy. Avastin is designed to block a protein called vascular endothelial growth factor, or VEGF. Normal cells make VEGF, but some cancer cells make too much VEGF. Blocking VEGF may prevent the growth of new blood vessels, including normal blood vessels and blood vessels that feed tumors.
Unlike chemotherapy that attacks the cancer cells, the purpose of Avastin is to block the blood supply that feeds the tumor. This can stop the tumor from growing.
[H4] Tumor before treatment
New blood vessels feed the tumor so it can grow and spread.

[IMG: Tumor before treatment]

[H4] Tumor with Avastin and chemotherapy
Avastin helps prevent blood vessels from reaching the tumor; this could starve the tumor.
However, in a study of mCRC patients who continued on Avastin for second-line treatment after a first-line treatment containing bevacizumab, tumors did not shrink.

[IMG: Tumor after treatment]

[IMG: Financial resources calculator]

[H2] GET FINANCIAL SUPPORT
Questions about Avastin treatment costs? Let us help you understand your financial assistance options.

Get Support

[IMG: How Avastin® (bevacizumab) is designed to work]

[H2] FIND OUT HOW AVASTIN IS DESIGNED TO WORK
Avastin is a tumor-starving therapy. Read more about how it's designed to work.

Learn More

[IMG: Avastin® (bevacizumab) patient resources]

[H2] PATIENT RESOURCES
Find helpful information and support.

Get Answers

[H4]
Important Safety Information & Indication

Back to Top

[H3] Indication
[H5] Metastatic Colorectal Cancer (mCRC)
Avastin is approved to treat metastatic colorectal cancer (mCRC) for:
First- or second-line treatment in combination with intravenous fluorouracil–based chemotherapy
Second-line treatment when used with fluoropyrimidine-based (combined with irinotecan or oxaliplatin) chemotherapy after cancer progresses following a first-line treatment containing bevacizumab
Avastin is not approved for use after surgery was used as the primary treatment in patients with colon cancer which has not spread to other parts of the body.

[H3] Possible serious side effects
Everyone reacts differently to Avastin therapy. So, it's important to know what the side effects are. Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if there are any signs of these side effects.
GI perforation. A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever
Abnormal passage in the body. This type of passage—known as a fistula—is an irregular connection from one part of the body to another and can sometimes be fatal
Wounds that don't heal. A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
Serious bleeding. This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor
Severe high blood pressure. Blood pressure that severely spikes or shows signs of affecting the brain. Blood pressure should be monitored every 2 to 3 weeks while on Avastin and after stopping treatment
Kidney problems. These may be caused by too much protein in the urine and can sometimes be fatal
Infusion-related reactions. These were uncommon with the first dose (less than 3% of patients). 0.4% of patients had severe reactions. Infusion-related reactions include high blood pressure or severe high blood pressure that may lead to stroke, trouble breathing, decreased oxygen in red blood cells, serious allergic reactions, chest pain, headache, tremors, and excessive sweating. Your doctor or nurse will monitor you for signs of infusion-related reactions
Severe stroke or heart problems. These may include blood clots, mini-stroke, heart attack, chest pain, and your heart may become too weak to pump blood to other parts of your body (congestive heart failure). These can sometimes be fatal
Nervous system and vision problems. Signs include headache, seizure, high blood pressure, sluggishness, confusion, and blindness

[H3] Side effects seen most often
In clinical studies across different types of cancer, some patients experienced the following side effects:
High blood pressure
Too much protein in the urine
Nosebleeds
Bleeding
Back pain
Headache
Taste change
Dry skin
Inflammation of the skin
Inflammation of the nose
Watery eyes

[H3] Avastin is not for everyone
Talk to your doctor if you are:
Undergoing surgery. Avastin should not be used for 28 days before or after surgery and until surgical wounds are fully healed
Pregnant or think you are pregnant. Data have shown that Avastin may harm your unborn baby. Use birth control while on Avastin. If you stop Avastin, you should keep using birth control for 6 months before trying to become pregnant
Planning to become pregnant. Taking Avastin could cause a woman’s ovaries to stop working and may impair her ability to have children
Breastfeeding. Breastfeeding while on Avastin may harm your baby, therefore, women should not breastfeed during and for 6 months after taking Avastin
For more information about your treatment or condition, talk to your doctor.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see full Product Information for additional important safety information.

[IMG: Recurrent Glioblastoma (rGBM) Treatment Option]

[IMG: Out-of-Pocket Support]

[H2] OUT-OF-POCKET SUPPORT
up to $25,000 per calendar year
The Genentech Oncology Co-pay Assistance Program can help you with the out-of-pocket costs for Avastin, if you’re eligible. Let us help you understand your financial assistance options.

Get Support

[IMG: How Avastin® (bevacizumab) is designed to work]

[H2] FIND OUT HOW AVASTIN IS DESIGNED TO WORK
Avastin is a tumor-starving therapy. Read more about how it's designed to work.

Learn More

[IMG: Avastin® (bevacizumab) Patient Resources]

[H2] PATIENT RESOURCES
Find helpful information and support.

Get Answers

[IMG: Learn about side effects]

Get answers on the possible side effects of Avastin therapy.

Learn more

[IMG: Avastin® (bevacizumab) Caregiver Tips]

Read about being a caregiver and find resources.

Learn more

*Eligibility criteria and annual limits apply. Not valid for patients using federal or state government programs to pay for their medications. Patients must be taking AVASTIN for an FDA-approved indication. See full TERMS AND CONDITIONS.

Avastin® (bevacizumab) is a biologic medicine used to treat recurrent glioblastoma (rGBM) in adults whose brain tumor has progressed after prior treatment. It is designed to target and inhibit vascular endothelial growth factor (VEGF), a protein that helps tumors grow new blood vessels. By blocking VEGF, Avastin helps limit the blood and oxygen supply that rGBM tumors need to grow. Learn more about how Avastin is designed to work in recurrent glioblastoma.
Avastin is given as an intravenous (IV) infusion, usually every 2 weeks for rGBM, through a vein or a port placed under the skin. Your care team will determine your treatment schedule and may continue Avastin as long as your tumor is controlled and side effects remain manageable.
Like all medicines for cancer, Avastin can cause side effects. These may include high blood pressure, too much protein in the urine, nosebleeds, bleeding, back pain, headache, taste change, dry skin, inflammation of the skin, inflammation of the nose, or watery eyes. Serious side effects may include GI perforation, wounds that don’t heal, or serious bleeding. Talk with your healthcare team right away if you notice any new or worsening symptoms.

[H4]
Important Safety Information & Indication

Back to Top

[H3] Indication
[H5] Glioblastoma (GBM)
Avastin is approved to treat glioblastoma (GBM) in adult patients whose cancer has progressed after prior treatment (recurrent or rGBM).

[H3] Possible serious side effects
Everyone reacts differently to Avastin therapy. So, it's important to know what the side effects are. Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if there are any signs of these side effects.
GI perforation. A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever
Abnormal passage in the body. This type of passage—known as a fistula—is an irregular connection from one part of the body to another and can sometimes be fatal
Wounds that don't heal. A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
Serious bleeding. This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor
Severe high blood pressure. Blood pressure that severely spikes or shows signs of affecting the brain. Blood pressure should be monitored every 2 to 3 weeks while on Avastin and after stopping treatment
Kidney problems. These may be caused by too much protein in the urine and can sometimes be fatal
Infusion-related reactions. These were uncommon with the first dose (less than 3% of patients). 0.4% of patients had severe reactions. Infusion-related reactions include high blood pressure or severe high blood pressure that may lead to stroke, trouble breathing, decreased oxygen in red blood cells, serious allergic reactions, chest pain, headache, tremors, and excessive sweating. Your doctor or nurse will monitor you for signs of infusion-related reactions
Severe stroke or heart problems. These may include blood clots, mini-stroke, heart attack, chest pain, and your heart may become too weak to pump blood to other parts of your body (congestive heart failure). These can sometimes be fatal
Nervous system and vision problems. Signs include headache, seizure, high blood pressure, sluggishness, confusion, and blindness

[H3] Side effects seen most often
In clinical studies across different types of cancer, some patients experienced the following side effects:
High blood pressure
Too much protein in the urine
Nosebleeds
Bleeding
Back pain
Headache
Taste change
Dry skin
Inflammation of the skin
Inflammation of the nose
Watery eyes

[H3] Avastin is not for everyone
Talk to your doctor if you are:
Undergoing surgery. Avastin should not be used for 28 days before or after surgery and until surgical wounds are fully healed
Pregnant or think you are pregnant. Data have shown that Avastin may harm your unborn baby. Use birth control while on Avastin. If you stop Avastin, you should keep using birth control for 6 months before trying to become pregnant
Planning to become pregnant. Taking Avastin could cause a woman’s ovaries to stop working and may impair her ability to have children
Breastfeeding. Breastfeeding while on Avastin may harm your baby, therefore, women should not breastfeed during and for 6 months after taking Avastin
For more information about your treatment or condition, talk to your doctor.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see full Product Information for additional important safety information.