Training Example: Gavreto (Pralsetinib) – Review the Data, Give Your Score & Compare to the Real AI Evaluation

[H1] GAVRETO®
[IMG: GAVRETO logo]
FOCUS WHERE IT MATTERS.Targeting RET matters because abnormal RET genes may be the cause of your metastatic non–small cell lung cancer or advanced thyroid cancer. If your cancer is RET positive (RET+), GAVRETO, a treatment designed to target RET, may be an option for you. RET+ metastatic NSCLC RET+ advanced thyroid cancerImages on this website do not depict actual patients.
[IMG: GAVRETO (pralsetinib)]
FOCUS WHERE IT MATTERS.Targeting RET matters because abnormal RET genes may be the cause of your metastatic non–small cell lung cancer or advanced thyroid cancer. If your cancer is RET positive (RET+), GAVRETO, a treatment designed to target RET, may be an option for you. RET+ metastatic NSCLC RET+ advanced thyroid cancerImages on this website do not depict actual patients.GAVRETO was approved in RET+ advanced thyroid cancer based on the percentage of patients whose tumor size shrank or disappeared after treatment and how long that response lasted. There are ongoing studies to confirm the benefit of GAVRETO.GAVRETO, also known as pralsetinib, is a targeted therapy that is taken by mouth once daily.It is used to treat certain cancers caused by abnormal RET genes.Ask your doctor if GAVRETO could be right for you.RET=rearranged during transfection.
[H4] Indications & Important Safety Information
[H4] Important Safety Information
[H2] WHAT IS GAVRETO?
GAVRETO is a prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection (RET) genes in:adults with non-small cell lung cancer (NSCLC) that has spreadadults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer workingYour healthcare provider will perform a test to make sure that GAVRETO is right for you.It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
[H2] IMPORTANT SAFETY INFORMATION
GAVRETO may cause serious side effects, including:Serious infections: GAVRETO may increase your risk for serious infections, including infections caused by bacteria, fungi, or viruses or infections that can happen when your immune system is weak (opportunistic infections). These serious infections can lead to hospitalization or death. Tell your healthcare provider right away if you get symptoms of an infection, including: chills, body aches, fever, confusion, nausea, vomiting, stomach pain, weakness, diarrhea, cough or shortness of breath, burning or pain when you urinate, or skin rash.Lung problems: GAVRETO may cause severe or life-threatening inflammation of the lungs during treatment, that can lead to death. Tell your healthcare provider right away if you have any new or worsening symptoms, including shortness of breath, cough, or fever.High blood pressure (hypertension): High blood pressure is common with GAVRETO and may sometimes be severe. You should check your blood pressure regularly during treatment with GAVRETO. Tell your healthcare provider if you have increased blood pressure readings or get any symptoms of high blood pressure, including confusion, headaches, shortness of breath, dizziness, or chest pain.Liver problems: Liver problems (increased liver function blood test results) can happen during treatment with GAVRETO and may sometimes be serious. Your healthcare provider will do blood tests before and during treatment with GAVRETO to check you for liver problems. Tell your healthcare provider right away if you get any signs or symptoms of liver problem during treatment, including yellowing of your skin or the white part of your eyes (jaundice), dark “tea-colored” urine, sleepiness, bleeding or bruising, loss of appetite, nausea or vomiting, or pain on the upper right of your stomach area.Bleeding problems: GAVRETO can cause bleeding which can be serious and cause death. Tell your healthcare provider if you have any signs or symptoms of bleeding during treatment, including vomiting blood or if your vomit looks like coffee grounds, pink or brown urine, red or black (looks like tar) stools, coughing up blood or blood clots, unusual bleeding or bruising of your skin, menstrual bleeding that is heavier than normal, unusual vaginal bleeding, nose bleeds that happen often, drowsiness or difficulty being awakened, confusion, headache, or change in speech.Tumor lysis syndrome (TLS): TLS is caused by a fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment, an abnormal heartbeat, and may sometimes lead to hospitalization. Your healthcare provider may do blood tests to check you for TLS. You should stay well hydrated during treatment with GAVRETO. Call your healthcare provider or get emergency medical help right away if you develop any of these symptoms during treatment with GAVRETO: nausea, vomiting, weakness, swelling, shortness of breath, muscle cramps, or seizures.Risk of wound healing problems: Wounds may not heal properly during treatment with GAVRETO. Tell your healthcare provider if you plan to have any surgery before or during treatment with GAVRETO. You should not take GAVRETO for at least 5 days before surgery. Your healthcare provider should tell you when you may start taking GAVRETO again after surgery.Before taking GAVRETO, tell your healthcare provider about all of your medical conditions, including if you:have an infectionhave lung or breathing problems other than lung cancerhave high blood pressurehave bleeding problemshave liver problemsplan to have surgery. You should stop taking GAVRETO at least 5 days before your planned surgery.are pregnant or plan to become pregnant. GAVRETO can harm your unborn baby.Females who are able to become pregnant:Your healthcare provider will do a pregnancy test before you start GAVRETO.Should use an effective form of non-hormonal birth control (contraception) during treatment with GAVRETO and for 2 weeks after your last dose of GAVRETO.Birth control methods that contain hormones (such as birth control pills, injections or transdermal system patches) may not work as well during treatment with GAVRETO.Talk to your healthcare provider about birth control methods that may be right for you during this time.Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with GAVRETO.Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 1 week after your last dose of GAVRETO.are breastfeeding or plan to breastfeed. It is not known if GAVRETO passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose of GAVRETO.Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking GAVRETO with other medicines may affect how GAVRETO works.The most common side effects of GAVRETO include: muscle and joint pain, constipation, diarrhea, tiredness, swelling of your face, arms, legs, hands, and feet (edema), fever, and cough.The most common severe abnormal blood test results with GAVRETO include: decreased white blood cell, red blood cell, and platelet counts, decreased levels of phosphate, body salt (sodium), calcium and potassium, abnormal liver function, increased levels of enzyme called alkaline phosphatase, and increased levels of potassium.GAVRETO may affect fertility in males and females, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.These are not all of the possible side effects of GAVRETO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.Click here for Full Prescribing Information, including Boxed Warning and Medication Guide.

[H1] FOCUSED WHERE IT MATTERS.
FOCUS WHERE IT MATTERS.Targeting RET matters because abnormal RET genes may be the cause of your metastatic non–small cell lung cancer. If your cancer is RET positive (RET+), GAVRETO, a treatment designed to target RET, may be an option for you.Image does not depict actual patient.FOCUS WHERE IT MATTERS.Targeting RET matters because abnormal RET genes may be the cause of your metastatic non–small cell lung cancer. If your cancer is RET positive (RET+), GAVRETO, a treatment designed to target RET, may be an option for you.Image does not depict actual patient.RET=rearranged during transfection.
[IMG: Clinical trial icon]
[H5] GAVRETO was effective in patients with RET+ mNSCLC
See the results
[IMG: Side effects icon]
[H5] What to expect with GAVRETO
See side effects
[IMG: Resources icon]
[H5] Resources that may help
Find resourcesGAV_LNG-26028 0326
[H4] Indications & Important Safety Information
[H4] Important Safety Information
[H2] WHAT IS GAVRETO?
GAVRETO is a prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection (RET) genes in:adults with non-small cell lung cancer (NSCLC) that has spreadadults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer workingYour healthcare provider will perform a test to make sure that GAVRETO is right for you.It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
[H2] IMPORTANT SAFETY INFORMATION
GAVRETO may cause serious side effects, including:Serious infections: GAVRETO may increase your risk for serious infections, including infections caused by bacteria, fungi, or viruses or infections that can happen when your immune system is weak (opportunistic infections). These serious infections can lead to hospitalization or death. Tell your healthcare provider right away if you get symptoms of an infection, including: chills, body aches, fever, confusion, nausea, vomiting, stomach pain, weakness, diarrhea, cough or shortness of breath, burning or pain when you urinate, or skin rash.Lung problems: GAVRETO may cause severe or life-threatening inflammation of the lungs during treatment, that can lead to death. Tell your healthcare provider right away if you have any new or worsening symptoms, including shortness of breath, cough, or fever.High blood pressure (hypertension): High blood pressure is common with GAVRETO and may sometimes be severe. You should check your blood pressure regularly during treatment with GAVRETO. Tell your healthcare provider if you have increased blood pressure readings or get any symptoms of high blood pressure, including confusion, headaches, shortness of breath, dizziness, or chest pain.Liver problems: Liver problems (increased liver function blood test results) can happen during treatment with GAVRETO and may sometimes be serious. Your healthcare provider will do blood tests before and during treatment with GAVRETO to check you for liver problems. Tell your healthcare provider right away if you get any signs or symptoms of liver problem during treatment, including yellowing of your skin or the white part of your eyes (jaundice), dark “tea-colored” urine, sleepiness, bleeding or bruising, loss of appetite, nausea or vomiting, or pain on the upper right of your stomach area.Bleeding problems: GAVRETO can cause bleeding which can be serious and cause death. Tell your healthcare provider if you have any signs or symptoms of bleeding during treatment, including vomiting blood or if your vomit looks like coffee grounds, pink or brown urine, red or black (looks like tar) stools, coughing up blood or blood clots, unusual bleeding or bruising of your skin, menstrual bleeding that is heavier than normal, unusual vaginal bleeding, nose bleeds that happen often, drowsiness or difficulty being awakened, confusion, headache, or change in speech.Tumor lysis syndrome (TLS): TLS is caused by a fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment, an abnormal heartbeat, and may sometimes lead to hospitalization. Your healthcare provider may do blood tests to check you for TLS. You should stay well hydrated during treatment with GAVRETO. Call your healthcare provider or get emergency medical help right away if you develop any of these symptoms during treatment with GAVRETO: nausea, vomiting, weakness, swelling, shortness of breath, muscle cramps, or seizures.Risk of wound healing problems: Wounds may not heal properly during treatment with GAVRETO. Tell your healthcare provider if you plan to have any surgery before or during treatment with GAVRETO. You should not take GAVRETO for at least 5 days before surgery. Your healthcare provider should tell you when you may start taking GAVRETO again after surgery.Before taking GAVRETO, tell your healthcare provider about all of your medical conditions, including if you:have an infectionhave lung or breathing problems other than lung cancerhave high blood pressurehave bleeding problemshave liver problemsplan to have surgery. You should stop taking GAVRETO at least 5 days before your planned surgery.are pregnant or plan to become pregnant. GAVRETO can harm your unborn baby.Females who are able to become pregnant:Your healthcare provider will do a pregnancy test before you start GAVRETO.Should use an effective form of non-hormonal birth control (contraception) during treatment with GAVRETO and for 2 weeks after your last dose of GAVRETO.Birth control methods that contain hormones (such as birth control pills, injections or transdermal system patches) may not work as well during treatment with GAVRETO.Talk to your healthcare provider about birth control methods that may be right for you during this time.Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with GAVRETO.Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 1 week after your last dose of GAVRETO.are breastfeeding or plan to breastfeed. It is not known if GAVRETO passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose of GAVRETO.Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking GAVRETO with other medicines may affect how GAVRETO works.The most common side effects of GAVRETO include: muscle and joint pain, constipation, diarrhea, tiredness, swelling of your face, arms, legs, hands, and feet (edema), fever, and cough.The most common severe abnormal blood test results with GAVRETO include: decreased white blood cell, red blood cell, and platelet counts, decreased levels of phosphate, body salt (sodium), calcium and potassium, abnormal liver function, increased levels of enzyme called alkaline phosphatase, and increased levels of potassium.GAVRETO may affect fertility in males and females, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.These are not all of the possible side effects of GAVRETO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.Click here for Full Prescribing Information, including Boxed Warning and Medication Guide.

[H1] FOCUSED WHERE IT MATTERS
FOCUS WHERE IT MATTERS.Targeting RET matters because abnormal RET genes may be the cause of your advanced thyroid cancer or thyroid cancer that has spread. If your cancer is RET positive (RET+), GAVRETO, a treatment designed to target RET, may be an option for you.GAVRETO was approved based on the percentage of patients whose tumor size shrank or disappeared after treatment and how long that response lasted. There are ongoing studies to confirm the benefit of GAVRETO.Image does not depict actual patient.FOCUS WHERE IT MATTERS.Targeting RET matters because abnormal RET genes may be the cause of your advanced thyroid cancer or thyroid cancer that has spread. If your cancer is RET positive (RET+), GAVRETO, a treatment designed to target RET, may be an option for you.GAVRETO was approved based on the percentage of patients whose tumor size shrank or disappeared after treatment and how long that response lasted. There are ongoing studies to confirm the benefit of GAVRETO.Image does not depict actual patient.RET=rearranged during transfection.
[IMG: Clinical trial icon]
[H5] GAVRETO was studied in patients with RET+ advanced thyroid cancer
See the results
[IMG: Side effects icon]
[H5] What to expect with GAVRETO
See side effects
[IMG: Resources icon]
[H5] Resources that may help
Find resourcesGAV_THR-26006 0126
[H4] Indications & Important Safety Information
[H4] Important Safety Information
[H2] WHAT IS GAVRETO?
GAVRETO is a prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection (RET) genes in:adults with non-small cell lung cancer (NSCLC) that has spreadadults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer workingYour healthcare provider will perform a test to make sure that GAVRETO is right for you.It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
[H2] IMPORTANT SAFETY INFORMATION
GAVRETO may cause serious side effects, including:Serious infections: GAVRETO may increase your risk for serious infections, including infections caused by bacteria, fungi, or viruses or infections that can happen when your immune system is weak (opportunistic infections). These serious infections can lead to hospitalization or death. Tell your healthcare provider right away if you get symptoms of an infection, including: chills, body aches, fever, confusion, nausea, vomiting, stomach pain, weakness, diarrhea, cough or shortness of breath, burning or pain when you urinate, or skin rash.Lung problems: GAVRETO may cause severe or life-threatening inflammation of the lungs during treatment, that can lead to death. Tell your healthcare provider right away if you have any new or worsening symptoms, including shortness of breath, cough, or fever.High blood pressure (hypertension): High blood pressure is common with GAVRETO and may sometimes be severe. You should check your blood pressure regularly during treatment with GAVRETO. Tell your healthcare provider if you have increased blood pressure readings or get any symptoms of high blood pressure, including confusion, headaches, shortness of breath, dizziness, or chest pain.Liver problems: Liver problems (increased liver function blood test results) can happen during treatment with GAVRETO and may sometimes be serious. Your healthcare provider will do blood tests before and during treatment with GAVRETO to check you for liver problems. Tell your healthcare provider right away if you get any signs or symptoms of liver problem during treatment, including yellowing of your skin or the white part of your eyes (jaundice), dark “tea-colored” urine, sleepiness, bleeding or bruising, loss of appetite, nausea or vomiting, or pain on the upper right of your stomach area.Bleeding problems: GAVRETO can cause bleeding which can be serious and cause death. Tell your healthcare provider if you have any signs or symptoms of bleeding during treatment, including vomiting blood or if your vomit looks like coffee grounds, pink or brown urine, red or black (looks like tar) stools, coughing up blood or blood clots, unusual bleeding or bruising of your skin, menstrual bleeding that is heavier than normal, unusual vaginal bleeding, nose bleeds that happen often, drowsiness or difficulty being awakened, confusion, headache, or change in speech.Tumor lysis syndrome (TLS): TLS is caused by a fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment, an abnormal heartbeat, and may sometimes lead to hospitalization. Your healthcare provider may do blood tests to check you for TLS. You should stay well hydrated during treatment with GAVRETO. Call your healthcare provider or get emergency medical help right away if you develop any of these symptoms during treatment with GAVRETO: nausea, vomiting, weakness, swelling, shortness of breath, muscle cramps, or seizures.Risk of wound healing problems: Wounds may not heal properly during treatment with GAVRETO. Tell your healthcare provider if you plan to have any surgery before or during treatment with GAVRETO. You should not take GAVRETO for at least 5 days before surgery. Your healthcare provider should tell you when you may start taking GAVRETO again after surgery.Before taking GAVRETO, tell your healthcare provider about all of your medical conditions, including if you:have an infectionhave lung or breathing problems other than lung cancerhave high blood pressurehave bleeding problemshave liver problemsplan to have surgery. You should stop taking GAVRETO at least 5 days before your planned surgery.are pregnant or plan to become pregnant. GAVRETO can harm your unborn baby.Females who are able to become pregnant:Your healthcare provider will do a pregnancy test before you start GAVRETO.Should use an effective form of non-hormonal birth control (contraception) during treatment with GAVRETO and for 2 weeks after your last dose of GAVRETO.Birth control methods that contain hormones (such as birth control pills, injections or transdermal system patches) may not work as well during treatment with GAVRETO.Talk to your healthcare provider about birth control methods that may be right for you during this time.Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with GAVRETO.Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 1 week after your last dose of GAVRETO.are breastfeeding or plan to breastfeed. It is not known if GAVRETO passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose of GAVRETO.Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking GAVRETO with other medicines may affect how GAVRETO works.The most common side effects of GAVRETO include: muscle and joint pain, constipation, diarrhea, tiredness, swelling of your face, arms, legs, hands, and feet (edema), fever, and cough.The most common severe abnormal blood test results with GAVRETO include: decreased white blood cell, red blood cell, and platelet counts, decreased levels of phosphate, body salt (sodium), calcium and potassium, abnormal liver function, increased levels of enzyme called alkaline phosphatase, and increased levels of potassium.GAVRETO may affect fertility in males and females, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.These are not all of the possible side effects of GAVRETO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.Click here for Full Prescribing Information, including Boxed Warning and Medication Guide.

By providing your email address below and clicking the “submit” button, you are unsubscribing from any future email communications about GAVRETO.GAV_PAN-26006 0126
[H4] Indications & Important Safety Information
[H4] Important Safety Information
[H2] WHAT IS GAVRETO?
GAVRETO is a prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection (RET) genes in:adults with non-small cell lung cancer (NSCLC) that has spreadadults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer workingYour healthcare provider will perform a test to make sure that GAVRETO is right for you.It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
[H2] IMPORTANT SAFETY INFORMATION
GAVRETO may cause serious side effects, including:Serious infections: GAVRETO may increase your risk for serious infections, including infections caused by bacteria, fungi, or viruses or infections that can happen when your immune system is weak (opportunistic infections). These serious infections can lead to hospitalization or death. Tell your healthcare provider right away if you get symptoms of an infection, including: chills, body aches, fever, confusion, nausea, vomiting, stomach pain, weakness, diarrhea, cough or shortness of breath, burning or pain when you urinate, or skin rash.Lung problems: GAVRETO may cause severe or life-threatening inflammation of the lungs during treatment, that can lead to death. Tell your healthcare provider right away if you have any new or worsening symptoms, including shortness of breath, cough, or fever.High blood pressure (hypertension): High blood pressure is common with GAVRETO and may sometimes be severe. You should check your blood pressure regularly during treatment with GAVRETO. Tell your healthcare provider if you have increased blood pressure readings or get any symptoms of high blood pressure, including confusion, headaches, shortness of breath, dizziness, or chest pain.Liver problems: Liver problems (increased liver function blood test results) can happen during treatment with GAVRETO and may sometimes be serious. Your healthcare provider will do blood tests before and during treatment with GAVRETO to check you for liver problems. Tell your healthcare provider right away if you get any signs or symptoms of liver problem during treatment, including yellowing of your skin or the white part of your eyes (jaundice), dark “tea-colored” urine, sleepiness, bleeding or bruising, loss of appetite, nausea or vomiting, or pain on the upper right of your stomach area.Bleeding problems: GAVRETO can cause bleeding which can be serious and cause death. Tell your healthcare provider if you have any signs or symptoms of bleeding during treatment, including vomiting blood or if your vomit looks like coffee grounds, pink or brown urine, red or black (looks like tar) stools, coughing up blood or blood clots, unusual bleeding or bruising of your skin, menstrual bleeding that is heavier than normal, unusual vaginal bleeding, nose bleeds that happen often, drowsiness or difficulty being awakened, confusion, headache, or change in speech.Tumor lysis syndrome (TLS): TLS is caused by a fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment, an abnormal heartbeat, and may sometimes lead to hospitalization. Your healthcare provider may do blood tests to check you for TLS. You should stay well hydrated during treatment with GAVRETO. Call your healthcare provider or get emergency medical help right away if you develop any of these symptoms during treatment with GAVRETO: nausea, vomiting, weakness, swelling, shortness of breath, muscle cramps, or seizures.Risk of wound healing problems: Wounds may not heal properly during treatment with GAVRETO. Tell your healthcare provider if you plan to have any surgery before or during treatment with GAVRETO. You should not take GAVRETO for at least 5 days before surgery. Your healthcare provider should tell you when you may start taking GAVRETO again after surgery.Before taking GAVRETO, tell your healthcare provider about all of your medical conditions, including if you:have an infectionhave lung or breathing problems other than lung cancerhave high blood pressurehave bleeding problemshave liver problemsplan to have surgery. You should stop taking GAVRETO at least 5 days before your planned surgery.are pregnant or plan to become pregnant. GAVRETO can harm your unborn baby.Females who are able to become pregnant:Your healthcare provider will do a pregnancy test before you start GAVRETO.Should use an effective form of non-hormonal birth control (contraception) during treatment with GAVRETO and for 2 weeks after your last dose of GAVRETO.Birth control methods that contain hormones (such as birth control pills, injections or transdermal system patches) may not work as well during treatment with GAVRETO.Talk to your healthcare provider about birth control methods that may be right for you during this time.Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with GAVRETO.Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 1 week after your last dose of GAVRETO.are breastfeeding or plan to breastfeed. It is not known if GAVRETO passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose of GAVRETO.Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking GAVRETO with other medicines may affect how GAVRETO works.The most common side effects of GAVRETO include: muscle and joint pain, constipation, diarrhea, tiredness, swelling of your face, arms, legs, hands, and feet (edema), fever, and cough.The most common severe abnormal blood test results with GAVRETO include: decreased white blood cell, red blood cell, and platelet counts, decreased levels of phosphate, body salt (sodium), calcium and potassium, abnormal liver function, increased levels of enzyme called alkaline phosphatase, and increased levels of potassium.GAVRETO may affect fertility in males and females, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.These are not all of the possible side effects of GAVRETO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.Click here for Full Prescribing Information, including Boxed Warning and Medication Guide.