Training Example: LINZESS (AbbVie and Ironwood Pharmaceuticals) – Review the Data, Give Your Score & Compare to the Real AI Evaluation

Learn how AbbVie and Ironwood can help you save. 1-855-226-3937

Constipation with belly pain
keep coming back?
[H1] Get Ahead of
Your
Returning
IBS‑C Symptoms
Talk to your doctor about LINZESS.

See How LINZESS Can Help

For adults with irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC), and pediatric patients 6 to 17 years of age with functional constipation (FC).

Are You Eligible to Save on LINZESS?

Learn More

LINZESS is the #1 Prescribed
IBS‍-‍C‍/‍CIC Branded Treatment
If your symptoms keep coming back and you don't know why, talk to your doctor. It may be time to consider a prescription treatment.

How LINZESS Works

Talking to Your Doctor
is Your First Step
Sharing your symptoms will help your doctor
know if LINZESS is right for you.

Prepare for Your Visit

Actor
Portrayal

Take the Gut Check Quiz
Answer 5 questions to learn more about IBS-C symptoms and help guide a conversation with your healthcare provider.

Check My Symptoms

Trying to figure out IBS-C or CIC? You're not alone.
There are millions of people experiencing the same symptoms as you. Learn their real stories and discover online support, all right here.

11.5
million
people suffer from IBS-C

(Irritable Bowel Syndrome

with Constipation).*

28.5
million
people suffer from CIC
(Chronic Idiopathic
Constipation).*

18
million
people are not satisfied with over-the-counter treatments alone and are seeking care with their doctor.†

*Estimated IBS-C/CIC sufferers within the U.S. through Kantar LINZESS Tracking Study; Jan-Dec 2020; general population sample only.
†IQVIA Total Patient Tracker – June 2020

[H2] LINZESS Patient Experiences
Hear from real LINZESS patients as they share their diagnosis and treatment experiences.

[H3]

View Transcript

[H3]

View Transcript

[H3]

View Transcript

See All Patient Videos

YOU COULD PAY AS LITTLE AS $30‡

[IMG: You may be eligible to get 90 days for 30 dollars]

You Could Pay as Little as $30 for a 30‍‍-‍‍day or 90‍‍-‍‍day Prescription‡
The LINZESS savings card enables many eligible, commercially insured patients to pay as little as $30 for a 30‍-‍day or 90‍-‍day prescription.‡

Sign Up Now

Already have a savings card? Activate now.

‡Maximum savings limit applies; patient out-of-pocket expense may vary. This offer is available to patients with commercial prescription insurance coverage for a valid prescription of LINZESS® (linaclotide) at the time the prescription is filled by the pharmacist and dispensed to the patient. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Please see Program Terms, Conditions, Privacy Notice, and Eligibility Criteria.

[H3] USES
LINZESS® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults and in children and adolescents 7 years of age and older, chronic idiopathic constipation (CIC) in adults, and functional constipation (FC) in children and adolescents 6 years of age and older. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 7 years of age.

[H3]
IMPORTANT RISK INFORMATION
Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).
Before you take LINZESS, tell your doctor about your medical conditions, including if you are:
Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Side Effects
LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.
Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).
Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.
These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.
Please see full Prescribing Information, including Boxed Warning, and Medication Guide.
US-LIN-250121

[H1] For Healthcare Professionals

This information provided on this website is intended for U.S. healthcare professionals only.
I certify that I am a U.S. Healthcare Professional.

No

YES

[H1] TALK TO A DOCTOR ONLINE TODAY*

Answer a few quick questions about your symptoms.

Connect with a doctor online to find out if it could be IBS-C or CIC.

If approved, pick up your prescription from your local pharmacy.

*Third-party website; does not constitute an endorsement or recommendation by AbbVie. A fee will be charged by the telemedicine provider.

Acknowledge and Continue

Cancel

You are now leaving LINZESS.com
By clicking “Acknowledge and Continue” above, you acknowledge and agree that neither AbbVie nor Ironwood does, in any way, endorse or recommend UpScript, a telemedicine provider, the qualifications of any physician associated with UpScript, or the quality of medical care any of those physicians can provide. You also acknowledge and agree that neither AbbVie nor Ironwood makes any guarantees that using UpScript will result in your desired outcome. It is wholly and solely your responsibility to assess the qualifications of a potential physician. AbbVie and Ironwood recommend that you meet and discuss the benefits and risks of all potential treatments with the potential physician. ABBVIE, IRONWOOD, AND THEIR RESPECTIVE AFFILIATES HEREBY DISCLAIM ANY LIABILITY ARISING FROM YOUR USE AND/OR RELIANCE ON THE INFORMATION CONTAINED ON THE UPSCRIPT WEBSITE. If you agree to the above, click “Acknowledge and Continue” to proceed to the UpScript website. If you do not agree to the above, click “Cancel” to remain on LINZESS.com.

[H1] TALK TO A DOCTOR ONLINE

Did you know you can talk to a doctor today from the comfort of your home? Connect with a healthcare professional online about your symptoms.

NO THANKS

GET STARTED

[H1] YOU ARE NOW LEAVING LINZESS.COM

Links to other websites are provided as a service to you. AbbVie and Ironwood Pharmaceuticals accept no responsibility for the content of other websites.
Would you like to continue?

No

Yes

[H1] YOU ARE NOW LEAVING LINZESS.COM

Links to third-party content are provided as a convenience for informational purposes only. They are not meant to replace your healthcare provider’s medical advice or treatment. The organizations listed have not endorsed AbbVie and Ironwood or any of their respective products or services. AbbVie and Ironwood have listed these sites only as a convenience and according to the permissions granted by their respective terms of use. Each organization has its own terms and conditions and privacy policy that you should read if you choose to contact any of them.
Would you like to continue?

No

Yes

[H3]

Transcript

[H1] Share

[H2] You are leaving an AbbVie hosted website.

You are leaving the AbbVie website and connecting to a site that is not under the control of AbbVie. AbbVie is not responsible for the content of any such site or any further links from such site. AbbVie is providing these links to you only as a convenience and the inclusion of any link does not imply the endorsement of the linked site by AbbVie. You should also be aware that the linked site may be governed by its own set of terms and conditions and privacy policy for which AbbVie has no responsibility.​
Conversely, the presence of this link does not imply the linked site’s endorsement of AbbVie.
​Do you wish to leave this site?​

No

Yes

US-LIN-250071

[H1] Terms and Conditions

These Online Terms of Use govern your access to the site, which links to these Online Terms of Use. These Online Terms of Use do not apply to AbbVie or Ironwood websites that do not link to these Online Terms of Use, or to third-party websites to which AbbVie or Ironwood websites may link. Your use of the site is subject to these Online Terms of Use and the Privacy Policy.
Without prejudice to your rights under applicable law, AbbVie and Ironwood reserve the right to amend these Online Terms of Use to reflect technological advancements, legal and regulatory changes and good business practices. If AbbVie and Ironwood change these Online Terms of Use, an updated version of these Online Terms of Use will reflect those changes and we will notify you of such changes by updating the effective date at the top of these Online Terms of Use. By accessing the site, you agree that you have read, understand, and agree to be bound to the current version of these Online Terms of Use which you may view when accessing the site. If you disagree with these Online Terms of Use, or are dissatisfied with the site, your sole and exclusive remedy is to discontinue using the site.
Disclaimers
You acknowledge and agree that:
Although we strive to provide the latest developments relating to our products and services, and other information about AbbVie or Ironwood, we do not warrant the accuracy, effectiveness, and suitability of any information contained in the site. Each person assumes full responsibility and all risks arising from use of the site. The information is presented “AS IS” and may include technical inaccuracies or typographical errors. AbbVie and Ironwood reserve the right to make additions, deletions, or modifications to the information contained on the site at any time without any prior notification.
ABBVIE AND IRONWOOD MAKE NO REPRESENTATIONS OR WARRANTIES OF ANY KIND OR NATURE WITH RESPECT TO THE INFORMATION OR CONTENT POSTED ON THE SITE. ABBVIE AND IRONWOOD HEREBY DISCLAIM ALL REPRESENTATIONS AND WARRANTIES, WHETHER EXPRESS OR IMPLIED, CREATED BY LAW, CONTRACT OR OTHERWISE, INCLUDING, WITHOUT LIMITATION, ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, TITLE OR NON-INFRINGEMENT. IN NO EVENT SHALL ABBVIE OR IRONWOOD BE LIABLE FOR ANY DAMAGES OF ANY KIND OR NATURE, INCLUDING, WITHOUT LIMITATION, DIRECT, INDIRECT, SPECIAL (INCLUDING LOSS OF PROFIT) CONSEQUENTIAL OR INCIDENTAL DAMAGES ARISING FROM OR IN CONNECTION WITH THE EXISTENCE OR USE OF THE SITE, AND/OR THE INFORMATION OR CONTENT POSTED ON THE SITE, REGARDLESS OF WHETHER ABBVIE OR IRONWOOD HAVE BEEN ADVISED AS TO THE POSSIBILITY OF SUCH DAMAGES.
AbbVie and Ironwood are not responsible, and provide no warranty whatsoever, for the accuracy, effectiveness, timeliness and suitability of any information or content obtained from third parties, including any hyperlinks to or from third-party sites. Except as otherwise provided on the site, AbbVie and Ironwood will not edit, censor, or otherwise control any content provided by third parties on any bulletin board, chat room or other similar forums posted on the site. Such information should, therefore, be considered as suspect and is not endorsed by AbbVie or Ironwood.
The site may contain forward-looking statements that reflect AbbVie and/or Ironwood’s current expectation regarding future events and business development. The forward-looking statements involve risks and uncertainties. Actual developments or results could differ materially from those projected and depend on a number of factors including, but not limited to, the success of current research programs, results of pending or future clinical trials, ongoing commercialization of its products, regulatory approvals of pharmaceuticals, validity and enforcement of its patents, the stability of its commercial relationships, and the general economic conditions. AbbVie and Ironwood intend to update the site on a regular basis but assume no obligation to update any of the content.
Your Use
You understand, acknowledge, and agree to the following:
By using the site, you agree not to disrupt or intercept our electronic information posted on the site or on any of AbbVie or Ironwood’s servers. You also agree not to attempt to circumvent any security features of the site, and to abide by all applicable, local, state, federal and international laws, rules, and regulations.
You grant to AbbVie the right to use all content you upload or otherwise transmit to the site, subject to these Online Terms of Use and AbbVie’s Privacy Policy in any manner AbbVie choos

Learn how AbbVie and Ironwood can help you save. 1-855-226-3937

Why LINZESS

[H1] LINZESS Is The #1
Prescribed
IBS-C/CIC
Branded Treatment

How Linzess Can Help

LINZESS CAN HELP RELIEVE SYMPTOMS OF IBS-C & CIC
You may have tried to relieve chronic constipation through over-the-counter treatments, dietary changes, or exercise.
But if your symptoms keep coming back, talk to your doctor. It may be time to consider LINZESS.
LINZESS is a once-daily pill that can help proactively manage symptoms of IBS-C and CIC in adults, including belly pain and
overall abdominal symptoms* (pain, discomfort, and bloating) associated with IBS-C.

IBS-C
Constipation (lumpy or hard stools, infrequent and incomplete bowel movements)
Belly pain
Overall abdominal symptoms* (pain, discomfort, and bloating)
*Abdominal symptoms were studied in combination, not individually.

CIC
Constipation (lumpy or hard stools, infrequent and incomplete bowel movements)

Check My Symptoms

How Linzess Works

How LINZESS Works

It isn’t a laxative. It’s a once-daily pill that can help proactively manage symptoms of IBS-C and CIC, including belly pain and overall abdominal symptoms* (pain, discomfort, and bloating) for adults with IBS-C.

LINZESS was the first approved treatment in a class of drugs that work differently than other medications.
It acts locally in the intestine and is thought to work in 2 ways:
Calms pain-sensing nerves†
Accelerates bowel movements

*Abdominal symptoms were studied in combination, not individually.
†This was seen in animal studies, and the relevance to humans is not known.

When Can I Expect To Start Seeing My IBS-C & CIC
Symptoms Improve With Linzess?
When LINZESS is taken daily, constipation relief is typically felt in about 1 week.

IBS-C
When LINZESS is taken daily, constipation relief is typically seen in about 1 week. Adults with IBS-C may begin to experience relief of belly pain and overall abdominal symptoms* (pain, discomfort, and bloating) in about 1 week, with symptoms typically improving over 12 weeks.

CIC

When LINZESS is taken daily, people with CIC may feel constipation relief in about 1 week, with symptoms typically improving over 12 weeks.

If you stop taking LINZESS, your symptoms could return in about 1 week.
*Abdominal symptoms were studied in combination, not individually.

[H2] Hear from real patients
Our panel of real people struggled for years before getting a correct diagnosis and starting LINZESS. In this episode, they discuss what to expect when getting started with LINZESS.

[H3]

View Transcript

[H3]

View Transcript

Side Effects of Linzess

Common Side Effects & What To Do If They Occur
LINZESS can cause serious side effects including diarrhea, which sometimes can be severe.

Diarrhea is the most common side effect, and often begins within the first 
2 weeks of treatment. Stop taking LINZESS and call your doctor right away if you experience severe diarrhea while taking LINZESS.

Other side effects include:
Gas
Abdominal (belly) pain
Swelling, or a feeling of fullness or pressure in your abdomen (distension)

Tell your doctor if you have any side effects that bother you or do not go away. These are not all of the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.
Go to the emergency room or call your doctor if you develop unusual or severe stomach-area (abdominal) pain, especially if you have bloody or black stools.
Keep LINZESS out of the reach of children.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA website or call 1-800-FDA-1088.

Linzess Patient Experiences

Hear From Real Patients with IBS-C & CIC
If you’re experiencing constipation symptoms again and again, you’re not alone. While estimates vary, nearly 11.5 million people suffer from IBS-C. It’s believed that as many as 28.5 million people suffer from CIC.‡

[H3]

View Transcript

‡Estimated IBS-C/CIC sufferers within the U.S. through Kantar LINZESS Tracking Study; Jan-Dec 2020; general population sample only.

HEAR THE CONSTIPATION CONVERSATION
Many people spend years dealing with constipation before getting a diagnosis. See what helped three real people with constipation get some clarity about their gut issues.

[H3]

View Transcript

[IMG: You may be eligible to get 90 days for 30 dollars]

You Could Pay as Little as $30 for a 30‑day or 90-‍‍day Prescription§
The LINZESS savings card enables many eligible, commercially insured patients to pay as little as $30 for a 30-day or 90-day prescription.§

Sign Up Now

Already have a savings card? Activate now.

§Maximum savings limit applies; patient out-of-pocket expense may vary. This offer is available to patients with commercial insurance coverage and a valid LINZESS prescription. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. This offer is not valid for cash-paying patients. Please see Program Terms, Conditions, Privacy Notice, and Eligibility Criteria.

[H3] USES
LINZESS® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults and in children and adolescents 7 years of age and older, chronic idiopathic constipation (CIC) in adults, and functional constipation (FC) in children and adolescents 6 years of age and older. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 7 years of age.

[H3]
IMPORTANT RISK INFORMATION
Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).
Before you take LINZESS, tell your doctor about your medical conditions, including if you are:
Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Side Effects
LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.
Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).
Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.
These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.
Please see full Prescribing Information, including Boxed Warning, and Medication Guide.
US-LIN-250121

[H1] For Healthcare Professionals

This information provided on this website is intended for U.S. healthcare professionals only.
I certify that I am a U.S. Healthcare Professional.

No

YES

[H1] TALK TO A DOCTOR ONLINE TODAY*

Answer a few quick questions about your symptoms.

Connect with a doctor online to find out if it could be IBS-C or CIC.

If approved, pick up your prescription from your local pharmacy.

*Third-party website; does not constitute an endorsement or recommendation by AbbVie. A fee will be charged by the telemedicine provider.

Acknowledge and Continue

Cancel

You are now leaving LINZESS.com
By clicking “Acknowledge and Continue” above, you acknowledge and agree that neither AbbVie nor Ironwood does, in any way, endorse or recommend UpScript, a telemedicine provider, the qualifications of any physician associated with UpScript, or the quality of medical care any of those physicians can provide. You also acknowledge and agree that neither AbbVie nor Ironwood makes any guarantees that using UpScript will result in your desired outcome. It is wholly and solely your responsibility to assess the qualifications of a potential physician. AbbVie and Ironwood recommend that you meet and discuss the benefits and risks of all potential treatments with the potential physician. ABBVIE, IRONWOOD, AND THEIR RESPECTIVE AFFILIATES HEREBY DISCLAIM ANY LIABILITY ARISING FROM YOUR USE AND/OR RELIANCE ON THE INFORMATION CONTAINED ON THE UPSCRIPT WEBSITE. If you agree to the above, click “Acknowledge and Continue” to proceed to the UpScript website. If you do not agree to the above, click “Cancel” to remain on LINZESS.com.

[H1] TALK TO A DOCTOR ONLINE

Did you know you can talk to a doctor today from the comfort of your home? Connect with a healthcare professional online about your symptoms.

NO THANKS

GET STARTED

[H1] YOU ARE NOW LEAVING LINZESS.COM

Links to other websites are provided as a service to you. AbbVie and Ironwood Pharmaceuticals accept no responsibility for the content of other websites.
Would you like to continue?

No

Yes

[H1] YOU ARE NOW LEAVING LINZESS.COM

Links to third-party content are provided as a convenience for informational purposes only. They are not meant to replace your healthcare provider’s medical advice or treatment. The organizations listed have not endorsed AbbVie and Ironwood or any of their respective products or services. AbbVie and Ironwood have listed these sites only as a convenience and according to the permissions granted by their respective terms of use. Each organization has its own terms and conditions and privacy policy that you should read if you choose to contact any of them.
Would you like to continue?

No

Yes

[H3]

Transcript

[H1] Share

[H2] You are leaving an AbbVie hosted website.

You are leaving the AbbVie website and connecting to a site that is not under the control of AbbVie. AbbVie is not responsible for the content of any such site or any further links from such site. AbbVie is providing these links to you only as a convenience and the inclusion of any link does not imply the endorsement of the linked site by AbbVie. You should also be aware that the linked site may be governed by its own set of terms and conditions and privacy policy for which AbbVie has no responsibility.​
Conversely, the presence of this link does not imply the linked site’s endorsement of AbbVie.
​Do you wish to leave this site?​

No

Yes

US-LIN-250071

[H1] Terms and Conditions

These Online Terms of Use govern your access to the site, which links to these Online Terms of Use. These Online Terms of Use do not apply to AbbVie or Ironwood websites that do not link to these Online Terms of Use, or to third-party websites to which AbbVie or Ironwood websites may link. Your use of the site is subject to these Online Terms of Use and the Privacy Policy.
Without prejudice to your rights under applicable law, AbbVie and Ironwood reserve the right to amend these Online Terms of Use to reflect technological advancements, legal and regulatory changes and good business practices. If AbbVie and Ironwood change these Online Terms of Use, an updated version of these Online Terms of Use will reflect those changes and we will notify you of such changes by updating the effective date at the top of these Online Terms of Use. By accessing the site, you agree that you have read, understand, and agree to be bound to the current version of these Online Terms of Use which you may view when accessing the site. If you disagree with these Online Terms of Use, or are dissatisfied with the site, your sole and exclusive remedy is to discontinue using the site.
Disclaimers
You acknowledge and agree that:
Although we strive to provide the latest developments relating to our products and services, and other information about AbbVie or Ironwood, we do not warrant the accuracy, effectiveness, and suitability of any information contained in the site. Each person assumes full responsibility and all risks arising from use of the site. The information is presented “AS IS” and may include technical inaccuracies or typographical errors. AbbVie and Ironwood reserve the right to make additions, deletions, or modifications to the information contained on the site at any time without any prior notification.
ABBVIE AND IRONWOOD MAKE NO REPRESENTATIONS OR WARRANTIES OF ANY KIND OR NATURE WITH RESPECT TO THE INFORMATION OR CONTENT POSTED ON THE SITE. ABBVIE AND IRONWOOD HEREBY DISCLAIM ALL REPRESENTATIONS AND WARRANTIES, WHETHER EXPRESS OR IMPLIED, CREATED BY LAW, CONTRACT OR OTHERWISE, INCLUDING, WITHOUT LIMITATION, ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, TITLE OR NON-INFRINGEMENT. IN NO EVENT SHALL ABBVIE OR I

Learn how AbbVie and Ironwood can help you save. 1-855-226-3937

Understanding Constipation

[H1] Symptoms & Types
of Constipation
Actor
Portrayal

Types of Constipation

The Difference Between Occasional & Chronic Constipation

Occasional Constipation
Sudden or short periods of difficult,
infrequent, or incomplete bowel
movements

Chronic Constipation
A medical condition with constipation symptoms that:
Keep coming back
Seem to last for a long time, more than 3 months

What Could Small,
Hard Stools Mean?
The Bristol Stool Form Scale makes it easier to understand and talk about stools (poop). The scale helps assess how long stools have been in the bowel by assigning them a number based on their size, shape, and consistency.

[IMG: Bowel movement chart]

IBS-C & CIC

Your constipation could be chronic, not occasional
If you’re experiencing constipation symptoms again and again, you’re not alone. IBS-C (Irritable Bowel Syndrome with Constipation) and CIC (Chronic Idiopathic Constipation) are two types of chronic constipation. “Idiopathic” means the cause is unknown.

[IMG: 11.5 million adults]

While estimates vary, nearly 11.5 million
adults in the U.S. suffer from IBS-C.*

[IMG: 28.5 million adults]

While estimates vary, as many as 28.5 million
adults in the U.S. suffer from CIC.*

*Estimated IBS-C/CIC sufferers within the U.S. through Kantar LINZESS Tracking Study; Jan-Dec 2020; general population sample only.

[H2] Get Some Clarity About Constipation
Many people spend years dealing with constipation before getting a diagnosis. See what helped three real people with constipation get some clarity about their gut issues.

[H3]

View Transcript

IBS-C & CIC Symptoms & Causes Comparison
IBS-C
CIC
Symptoms
CONSTIPATION
Lumpy or hard stools
Incomplete bowel movements
<3 bowel movements a week
ABDOMINAL SYMPTOMS
Abdominal (belly) pain
Discomfort
Bloating
CONSTIPATION
Lumpy or hard stools
Incomplete bowel movements
<3 bowel movements a week
Causes
The cause of IBS-C is unknown, but researchers believe several factors may contribute to the condition.
Fluid absorption: the colon may be absorbing too much fluid from stools, or the muscles in the colon may be moving too slowly. This can cause stools to become dry, hard, and difficult to pass.
Nerve sensitivity: the nerves in the intestines may be extra sensitive, causing sufferers to feel more belly pain or discomfort than those who do not have IBS‑C.

Brain-bowel connection: there could be a miscommunication between the brain and the bowel (gut) that causes a change in bowel movements.
Researchers believe several factors may contribute to the development of CIC.

Fluid absorption: the colon may be absorbing too much fluid from stools, or the muscles in the colon may be moving too slowly. This can cause stools to become dry, hard, and difficult to pass.
Nerve sensitivity: some patients have less nerve sensitivity, which may reduce the urge to have a bowel movement. Other patients may have extra-sensitive nerves, which can cause discomfort.
Muscle contractions: the muscles of the colon may be contracting too slowly, which can reduce the movement of stool through the colon and cause infrequent stools.

How Do Doctors Diagnose
IBS-C & CIC?
Dr. Susan Lucak, a gastroenterologist who practices in New York City, explains
what she looks for and how she helps her patients with IBS-C and CIC.

[H3]

View Transcript

Actor
Portrayal

Could It Be More Than 
Occasional Constipation?
Answer 5 quick questions to learn about IBS-C and CIC to prepare for your appointment.

Check My Symptoms

Constipation Treatment Options

Types of Treatments & When to consider a Prescription
When you’re experiencing constipation, your initial reaction might be to grab an over-the-counter treatment from the pharmacy aisle. But if your symptoms keep coming back and you don’t know why, it could be a chronic medical condition. You may want to talk to your doctor about a daily prescription treatment.

Over-the-Counter Treatments
Over-the-counter medications for occasional constipation may include:
Laxatives (like MiraLAX®, Phillips’® Milk of Magnesia, or Dulcolax®)
Fiber products (such as Metamucil®)
Stool softeners (like Colace®)
These treatments may provide relief for occasional constipation, but should not be taken for longer than 1 week unless directed by a doctor.
All trademarks are the property of their respective owners.

Prescription Medications
If you have more than occasional constipation, you may want to talk to a doctor about prescription options like LINZESS.
LINZESS is a once-daily prescription treatment for adults with IBS-C or CIC.
LINZESS helps you have more frequent and complete bowel movements and helps relieve belly pain and overall abdominal symptoms† (pain, discomfort, and bloating) associated with IBS-C.

How LINZESS Can Help

†Abdominal symptoms were studied in combination, not individually.

Pediatric Functional Constipation

Help Relieve Your Child's Functional Constipation
(Ages 6–17 Years)
If your child has been struggling to go to the bathroom regularly or suffering from difficult bowel movements, it may be a sign they have a medical condition known as functional constipation.
It may be time to talk to a doctor about LINZESS, the first and only prescription medicine approved for functional constipation in children and adolescents
6–17 years old.

How Does LINZESS Help with Functional Constipation?
Managing infrequent bowel movements
This was seen in a clinical study of patients
6–17 years of age with functional constipation

What is LINZESS?
Not a laxative
In a different category of drugs than over-the-counter laxatives
The first and only FDA-approved prescription treatment for pediatric functional constipation

If your child has functional constipation, your child’s doctor can prescribe one 72-mcg
LINZESS pill, just once a day—there's no need to measure or adjust doses.

See How to Give Your Child LINZESS

[IMG: You may be eligible to get 90 days for 30 dollars]

You Could Pay as Little as $30 for a 30‑day or 90‑day Prescription‡
The LINZESS savings card enables many eligible, commercially insured patients to pay as little as $30 for a 30‑day or 90-day prescription.‡

Sign Up Now

Already have a savings card? Activate now.

‡Maximum savings limit applies; patient out-of-pocket expense may vary. This offer is available to patients with commercial insurance coverage and a valid LINZESS prescription. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. This offer is not valid for cash-paying patients. Please see Program Terms, Conditions, Privacy Notice, and Eligibility Criteria.

[H3] USES
LINZESS® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults and in children and adolescents 7 years of age and older, chronic idiopathic constipation (CIC) in adults, and functional constipation (FC) in children and adolescents 6 years of age and older. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 7 years of age.

[H3]
IMPORTANT RISK INFORMATION
Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).
Before you take LINZESS, tell your doctor about your medical conditions, including if you are:
Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Side Effects
LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.
Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).
Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.
These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.
Please see full Prescribing Information, including Boxed Warning, and Medication Guide.
US-LIN-250121

[H1] For Healthcare Professionals

This information provided on this website is intended for U.S. healthcare professionals only.
I certify that I am a U.S. Healthcare Professional.

No

YES

[H1] TALK TO A DOCTOR ONLINE TODAY*

Answer a few quick questions about your symptoms.

Connect with a doctor online to find out if it could be IBS-C or CIC.

If approved, pick up your prescription from your local pharmacy.

*Third-party website; does not constitute an endorsement or recommendation by AbbVie. A fee will be charged by the telemedicine provider.

Acknowledge and Continue

Cancel

You are now leaving LINZESS.com
By clicking “Acknowledge and Continue” above, you acknowledge and agree that neither AbbVie nor Ironwood does, in any way, endorse or recommend UpScript, a telemedicine provider, the qualifications of any physician associated with UpScript, or the quality of medical care any of those physicians can provide. You also acknowledge and agree that neither AbbVie nor Ironwood makes any guarantees that using UpScript will result in your desired outcome. It is wholly and solely your responsibility to assess the qualifications of a potential physician. AbbVie and Ironwood recommend that you meet and discuss the benefits and risks of all potential treatments with the potential physician. ABBVIE, IRONWOOD, AND THEIR RESPECTIVE AFFILIATES HEREBY DISCLAIM ANY LIABILITY ARISING FROM YOUR USE AND/OR RELIANCE ON THE INFORMATION CONTAINED ON THE UPSCRIPT WEBSITE. If you agree to the above, click “Acknowledge and Continue” to proceed to the UpScript website. If you do not agree to the above, click “Cancel” to remain on LINZESS.com.

[H1] TALK TO A DOCTOR ONLINE

Did you know you can talk to a doctor today from the comfort of your home? Connect with a healthcare professional online about your symptoms.

NO THANKS

GET STARTED

[H1] YOU ARE NOW LEAVING LINZESS.COM

Links to other websites are provided as a service to you. AbbVie and Ironwood Pharmaceuticals accept no responsibility for the content of other websites.
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[H1] YOU ARE NOW LEAVING LINZESS.COM

Links to third-party content are provided as a convenience for informational purposes only. They are not meant to replace your healthcare provider’s medical advice or treatment. The organizations listed have not endorsed AbbVie and Ironwood or any of their respective products or services. AbbVie and Ironwood have listed these sites only as a convenience and according to the permissions granted by their respective terms of use. Each organization has its own terms and conditions and privacy policy that you should read if you choose to contact any of them.
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[H3]

Transcript

[H1] Share

[H2] You are leaving an AbbVie hosted website.

You are leaving the AbbVie website and connecting to a site that is not under the control of AbbVie. AbbVie is not responsible for the content of any such site or any further links from such site. AbbVie is providing these links to you only as a convenience and the inclusion of any link does not imply the endorsement of the linked site by AbbVie. You should also be aware that the linked site may be governed by its own set of terms and conditions and privacy policy for which AbbVie has no responsibility.​
Conversely, the presence of this link does not imply the linked site’s endorsement of AbbVie.
​Do you wish to leave this site?​

No

Yes

US-LIN-250071

[H1] Terms and Conditions

These Online Terms of Use govern your access to the site, which links to these Online Terms of Use. These Online Terms of Use do not apply to AbbVie or Ironwood websites that do not link to these Online Terms of Use, or to third-party websites to which AbbVie or Ironwood websites may link. Your use of the site is subject to these Online Terms of Use and the Privacy Policy.
Without prejudice to your rights under applicable law, AbbVie and Ironwood reserve the right

Learn how AbbVie and Ironwood can help you save. 1-855-226-3937

Savings & Support

[H1] See If You're Eligible
To Save on LINZESS

Savings

You Could Pay as Little as $30* For 90 or 30 Days of LINZESS

[IMG: You may be eligible to get 90 days for 30 dollars]

Whether you start with a 90-day or 30-day prescription, you could be eligible to pay as little as $30* with the LINZESS Savings Program.
Talk to a doctor about a 90-day prescription to potentially maximize your savings and minimize trips to the pharmacy.

Sign Up Now

Already have a savings card? Activate now.

Choose how you want to sign up:

Text
“LINZESS” to 59257 to sign up and add your card to your phone.†

Text to Sign Up

Call
1-855-859-5614 and we’ll help you sign up and mail out your card.

Call to Sign Up

Click
to sign up online and download your card.

Sign Up Online

*Maximum savings limit applies; patient out-of-pocket expense may vary. This offer is available to patients with commercial insurance coverage and a valid LINZESS prescription. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. This offer is not valid for cash-paying patients. Please see Program Terms, Conditions, Privacy Notice, and Eligibility Criteria.
†By texting LINZESS to 59257, you will receive your activated savings card. 10 msgs. per enrollment activation. Message and data rates apply. Reply HELP for help; reply STOP to cancel. Consent to receiving SMS messages is not a condition of purchase of goods or services. Please see full Terms and Privacy Policy.

Program Terms, Conditions, and Eligibility Criteria

This offer is valid only for patients with commercial prescription insurance coverage, who are 6 years of age or older and meet eligibility criteria and is good for use only with a valid prescription for LINZESS® (linaclotide) capsules 72 mcg, 145 mcg, or 290 mcg at the time the prescription is filled by the pharmacist and dispensed to the patient. This offer is not valid for use by patients enrolled in Medicare, Medicaid, or other federal or state programs (including any state pharmaceutical assistance programs, TRICARE, Department of Defense or Veterans Affairs programs), or private indemnity or HMO insurance plans that reimburse you for the entire cost of your prescription drugs or where prohibited by law or by the patient’s health insurance provider. If at any time a patient begins receiving prescription drug coverage under any such federal, state, or government-funded healthcare program, patient will no longer be eligible to use the LINZESS savings card. Patients may not use this card if they are Medicare-eligible and enrolled in an employer-sponsored health plan or prescription drug benefit program for retirees. This offer is not valid for cash-paying patients. Offer good only in the USA, including Puerto Rico, at participating retail pharmacies. Patients residing in or receiving treatment in certain states may not be eligible to participate in this program. Depending on your insurance coverage, eligible patients may pay as little as $30 per 30, 60, or 90-day supply for each of up to twelve (12) prescription fills per calendar year. One 60-day supply counts as two (2) fills and one 90-day supply counts as three (3) fills of the total twelve (12) fills. AbbVie reserves the right to rescind, revoke, or amend this offer without notice. Void if prohibited by law, taxed, or restricted. Patients may not seek reimbursement for value received under the LINZESS Savings Program from any third-party payers. This offer is not transferable. The selling, purchasing, trading, or counterfeiting of this card is prohibited by law. This offer has no cash value and may not be used in combination with any other discount, coupon, rebate, free trial, or similar offer for the specified prescription. Subject to all other terms and conditions, the maximum annual benefit that may be available solely for the patient’s benefit under the co-pay assistance program is $2,280.00 per calendar year. The actual application and use of the benefit available under the co-pay assistance program may vary on a monthly, quarterly, and/or annual basis depending on each individual patient’s plan of insurance and other prescription drug costs. This offer is not health insurance. By redeeming this offer, you acknowledge that you are an eligible patient and that you understand and agree to comply with the terms and conditions of this offer. To learn about AbbVie’s privacy practices and your privacy choices, visit https://abbv.ie/corpprivacy.

Financial Support

[H2] What Financial Help Is Available?
The list price, also known as the Wholesale Acquisition Cost (WAC),‡ for LINZESS®  is
$282.48 a month (as of January 2026). The WAC may not reflect the price paid by patients.
Insurance Information§
Commercial Insurance (Usually provided by an employer)
Depending on your plan, your monthly copay for LINZESS may vary. Eligible patients may pay  as little as $30 for a 30-day or 90-day prescription* with a LINZESS savings card. About 92% of LINZESS ® prescriptions have an out-of-pocket cost between  $0–$50 per month. || This cost includes use of LINZESS savings cards.
Medicaid
About 100% of LINZESS prescriptions have an out-of-pocket cost between $0–$10 per month depending on state plan.
Medicare Part D
About 93% of LINZESS prescriptions have an out-of-pocket cost between $0–$50 per month ||, depending on coverage phase. Out-of-pocket cost for LINZESS may vary depending on patient’s other medication costs. Most Medicare patients have standard Part D prescription coverage, which has different costs depending on deductibles and coverage gaps.
Medicare Low Income Subsidy (LIS)
Most patients who qualify for Full Extra Help LIS pay $12.15 per month starting January 1, 2025.
Other Insurance (VA, DOD, TRICARE, Others)
The DOD represents active military and non active (retired) military members plus their families. Members can go to the MTF (Military Treatment Facility)/military base pharmacy or TRICARE (retail pharmacy), or Mail Order for prescription. LINZESS co-pays range from $0 to $43 depending on if you are active, non active (retired), or a family member and where you pick up your prescription. VA LINZESS co-pay is $11.
Uninsured or if you cannot afford your medication
If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

‡The price at which AbbVie® sells its products to wholesalers.
§Important details about understanding your individual costs: The chart above provides cost information based on what a person with the type of coverage listed may pay. Your type of health or prescription insurance plan will determine exactly how much you will pay. Information listed is accurate as of January 2022 and is based on publicly available benefit design information for Medicaid and Medicare Part D out-of-pocket costs for the 2022 plan year.
||IQVIA LAAD Dispensed TRx as of Jan 2025 to Dec 2025.

Insurance Coverage Support
To help you understand your coverage and what your out-of-pocket costs may be, it’s important to verify your benefits.
And even if your LINZESS isn’t covered, there may be ways to save on your prescription. An Insurance Specialist can talk you through your coverage and help identify potential savings options—regardless of your insurance coverage.

MyAbbvie Assist
If you are having difficulty paying for your medicine, myAbbVie Assist may be able to help.
myAbbVie Assist, our patient assistance program, provides AbbVie medicine to qualifying patients. It is intended for people that live in the United States, have limited or no health insurance coverage and demonstrate qualifying financial need.
Visit AbbVie.com/PatientAccessSupport to learn more.

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Prepare for your visit by taking the Gut Check Quiz and create your own discussion guide. You’ll be ready to better describe your symptoms at your next doctor’s appointment.

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[H3] USES
LINZESS® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults and in children and adolescents 7 years of age and older, chronic idiopathic constipation (CIC) in adults, and functional constipation (FC) in children and adolescents 6 years of age and older. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 7 years of age.

[H3]
IMPORTANT RISK INFORMATION
Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).
Before you take LINZESS, tell your doctor about your medical conditions, including if you are:
Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Side Effects
LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.
Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).
Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.
These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.
Please see full Prescribing Information, including Boxed Warning, and Medication Guide.
US-LIN-250121

[H1] For Healthcare Professionals

This information provided on this website is intended for U.S. healthcare professionals only.
I certify that I am a U.S. Healthcare Professional.

No

YES

[H1] TALK TO A DOCTOR ONLINE TODAY*

Answer a few quick questions about your symptoms.

Connect with a doctor online to find out if it could be IBS-C or CIC.

If approved, pick up your prescription from your local pharmacy.

*Third-party website; does not constitute an endorsement or recommendation by AbbVie. A fee will be charged by the telemedicine provider.

Acknowledge and Continue

Cancel

You are now leaving LINZESS.com
By clicking “Acknowledge and Continue” above, you acknowledge and agree that neither AbbVie nor Ironwood does, in any way, endorse or recommend UpScript, a telemedicine provider, the qualifications of any physician associated with UpScript, or the quality of medical care any of those physicians can provide. You also acknowledge and agree that neither AbbVie nor Ironwood makes any guarantees that using UpScript will result in your desired outcome. It is wholly and solely your responsibility to assess the qualifications of a potential physician. AbbVie and Ironwood recommend that you meet and discuss the benefits and risks of all potential treatments with the potential physician. ABBVIE, IRONWOOD, AND THEIR RESPECTIVE AFFILIATES HEREBY DISCLAIM ANY LIABILITY ARISING FROM YOUR USE AND/OR RELIANCE ON THE INFORMATION CONTAINED ON THE UPSCRIPT WEBSITE. If you agree to the above, click “Acknowledge and Continue” to proceed to the UpScript website. If you do not agree to the above, click “Cancel” to remain on LINZESS.com.

[H1] TALK TO A DOCTOR ONLINE

Did you know you can talk to a doctor today from the comfort of your home? Connect with a healthcare professional online about your symptoms.

NO THANKS

GET STARTED

[H1] YOU ARE NOW LEAVING LINZESS.COM

Links to other websites are provided as a service to you. AbbVie and Ironwood Pharmaceuticals accept no responsibility for the content of other websites.
Would you like to continue?

No

Yes

[H1] YOU ARE NOW LEAVING LINZESS.COM

Links to third-party content are provided as a convenience for informational purposes only. They are not meant to replace your healthcare provider’s medical advice or treatment. The organizations listed have not endorsed AbbVie and Ironwood or any of their respective products or services. AbbVie and Ironwood have listed these sites only as a convenience and according to the permissions granted by their respective terms of use. Each organization has its own terms and conditions and privacy policy that you should read if you choose to contact any of them.
Would you like to continue?

No

Yes

[H3]

Transcript

[H1] Share

[H2] You are leaving an AbbVie hosted website.

You are leaving the AbbVie website and connecting to a site that is not under the control of AbbVie. AbbVie is not responsible for the content of any such site or any furthe