Training Example: TAGRISSO (AstraZeneca) – Review the Data, Give Your Score & Compare to the Real AI Evaluation

[H1] TAGRIS SO I can...

[H1] TAGRISSO is approved to treat certain types of
EGFR+ non-small cell lung cancer (NSCLC)

[IMG: Deb painting a picture]

[IMG: I get to be me text]

[IMG: Lloyd playing drums]

What is TAGRISSO approved to treat?
NEW
FROM
TAGRISSO

What is TAGRISSO approved to treat?

EARLY-STAGE (STAGE 1-3) EGFR+ NSCLC Following tumor removal by surgery (adjuvant)
[IMG: Right arrow]

NEW
FROM
TAGRISSO

LOCALLY ADVANCED UNRESECTABLE
(STAGE 3) EGFR+ NSCLC After chemotherapy and radiation therapy for NSCLC that spread to nearby tissues and can't be removed by surgery (unresectable)
[IMG: Right arrow]

LATE-STAGE EGFR+ NSCLC NSCLC that has spread to tissues around the lungs (locally advanced)* or to other parts of the body (metastatic)
[IMG: Right arrow]

Lloyd

Deb's animation

[H2] IMPORTANT SAFETY INFORMATION

TAGRISSO may cause serious side effects, including:

Lung problems. TAGRISSO may cause severe lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you have any new or worsening lung symptoms, including trouble breathing, shortness of breath, cough, or fever
Heart problems, including heart failure. TAGRISSO may cause heart problems that may lead to death. Your healthcare provider should check your heart function before you start taking TAGRISSO and during treatment as needed. Tell your healthcare provider right away if you have any of the following signs and symptoms of a heart problem: feeling like your heart is pounding or racing, shortness of breath, swelling of your ankles and feet, dizziness, feeling lightheaded, or feeling faint
Eye problems. TAGRISSO may cause eye problems. Tell your healthcare provider right away if you have symptoms of eye problems which may include watery eyes, sensitivity to light, eye pain, eye redness, or vision changes. Your healthcare provider may send you to see an eye specialist (ophthalmologist) if you get eye problems with TAGRISSO
Skin problems. TAGRISSO may cause skin problems. Tell your healthcare provider right away if you develop skin reactions that look like rings (target lesions), severe blistering or peeling of the skin
Inflammation of the blood vessels in your skin. TAGRISSO may cause blood vessel problems in your skin. Tell your healthcare provider right away if you develop purple spots or redness of the skin that does not fade in color when pressed (non-blanching) on your lower arms, lower legs, or buttocks or large hives on the main part of your body (trunk) that do not go away within 24 hours and look bruised
Blood and bone marrow problems. TAGRISSO may cause a condition where your bone marrow cannot make enough new blood cells (aplastic anemia), and which may lead to death. Your healthcare provider will monitor your blood cell counts before you start and during treatment with TAGRISSO. Tell your healthcare provider right away if you develop any signs and symptoms of blood and bone marrow problems, including a new fever or fever that does not go away (≥100.4 °F), easy bruising or bleeding that will not stop, unusually pale skin, infection, tiredness, or weakness

Before taking TAGRISSO, tell your healthcare provider about all of your medical conditions, including if you:

have lung or breathing problems other than your lung cancer
have heart problems, including a condition called long QTc syndrome
have problems with your electrolytes, such as sodium, potassium, calcium or magnesium
have a history of eye problems
are pregnant or plan to become pregnant. TAGRISSO can harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with TAGRISSO or think you may be pregnant

Females who are able to become pregnant should have a pregnancy test before starting treatment with TAGRISSO. You should use effective birth control (contraception) during treatment with TAGRISSO and for 6 weeks after the last dose of TAGRISSO
Males who have female partners that are able to become pregnant should use effective birth control during treatment with TAGRISSO and for 4 months after the last dose of TAGRISSO

females who are breastfeeding or plan to breastfeed. It is not known if TAGRISSO passes into your breast milk. Do not breastfeed during treatment with TAGRISSO and for 2 weeks after your last dose of TAGRISSO. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements. Especially tell your healthcare provider if you take a heart or blood pressure medicine
The most common side effects of TAGRISSO when given alone include:

low white blood cell counts
low platelet counts
low red blood cell counts (anemia)
diarrhea
rash
muscle, bone, or joint pain

changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
dry skin
mouth sores
tiredness

low white blood cell counts
low platelet counts
low red blood cell counts (anemia)
diarrhea
rash
muscle, bone, or joint pain
changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
dry skin
mouth sores
tiredness

The most common side effects of TAGRISSO when given alone after treatment with platinum-based chemotherapy and radiation treatment include:

low white blood cell counts
lung problems
low platelet counts
rash
diarrhea

changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
cough
COVID-19

low white blood cell counts
lung problems
low platelet counts
rash
diarrhea
changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
cough
COVID-19

The most common side effects of TAGRISSO in combination with pemetrexed and platinum-based chemotherapy include:

low white blood cell counts
low platelet counts
rash
diarrhea
mouth sores

changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail

dry skin
increase of a substance in the blood called creatinine

low white blood cell counts
low platelet counts
rash
diarrhea
mouth sores
changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
dry skin
increase of a substance in the blood called creatinine

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of TAGRISSO. For more information, ask your healthcare provider or pharmacist.
[H3] What is TAGRISSO?

TAGRISSO is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC) that has certain abnormal epidermal growth factor receptor (EGFR) gene(s):

to help prevent your lung cancer from coming back after your tumor(s) has been removed by surgery, or
when your lung cancer has spread to nearby tissues (locally advanced), that is unable to be removed (unresectable) by surgery and has responded or stabilized following chemotherapy and radiation treatment, or
as your first treatment when your lung cancer has spread to other parts of the body (metastatic), or
in combination with pemetrexed and platinum-based chemotherapy, as your first treatment when your lung cancer has spread to nearby tissues (locally advanced) or to other parts of the body (metastatic), or
when your lung cancer has spread to other parts of the body (metastatic) and you have had previous treatment with an EGFR tyrosine kinase inhibitor (TKI) medicine that did not work or is no longer working.

Your healthcare provider will perform a test to make sure that TAGRISSO is right for you.
It is not known if TAGRISSO is safe and effective in children.
Please see complete Prescribing Information, including Patient Information for TAGRISSO.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
You may report side effects related to AstraZeneca products
[IMG: link Icon]
.
EGFR is epidermal growth factor receptor; EGFR+ is epidermal growth factor receptor mutation-positive; NSCLC is non-small cell lung cancer.
EGFR+ is epidermal growth factor receptor mutation-positive; NSCLC is non-small cell lung cancer.

[H3]
IMPORTANT SAFETY INFORMATION

see-more

[H2] You are about to enter the TAGRISSOHCP.com site for Healthcare Professionals

The information in this site is intended for US Healthcare Professionals only.
CONTINUE

[H2] You are about to enter the TAGRISSONurse.com site for Healthcare Professionals

The information in this site is intended for US Healthcare Professionals only.
CONTINUE

[H2] Contact Us

General or Product Questions

If you are in the United States and would like additional information regarding AstraZeneca products, you can contact AstraZeneca by phone at 1-800-236-9933 (Monday - Friday 8 AM - 6 PM ET, excluding holidays). Outside these hours and on holidays, an after-hours service is available to assist with any urgent medical inquiries.

To enroll, please provide the following information. Questions with an * are required.

First name*

Last name*

E-mail address*;

Confirm e-mail address*

What type of lung cancer treatment are you or your loved one interested in?*;

Early-stage (stage 1-3) EGFR+ non-small cell lung cancer (NSCLC) following removal by surgery (adjuvant)
Late-stage EGFR+ non-small cell lung cancer (NSCLC) that has spread to nearby tissues around the lungs (locally advanced) or has spread to other parts of the body (metastatic)

Have you or your loved one been prescribed or are currently taking TAGRISSO?*

Yes
Error: Please fill out this field.Error: Please fill out this field.Error: Please fill out this field.Error: Please fill out this field.Error: Please fill out this field.Error: Please fill out this field.Error: Please fill out this field.Error: Please fill out this field.Error: Please fill out this field.Error: Please fill out this field.No

By completing this registration, I confirm that I am at least 18 years old, agree to receive information about TAGRISSO, and may receive information about other NSCLC medicines and services related to my condition which includes, but is not limited to, educational and promotional materials, special offers and services as well as for market research purposes, which includes contacting me to participate in focus groups, surveys or interviews. This may include AstraZeneca or a third party working on AstraZeneca's behalf contacting me by telephone, email and text message regarding AstraZeneca support program that may be of interest to me. Information provided by AstraZeneca does not take the place of talking to your healthcare provider about your treatment or condition. If you no longer want to receive health-related materials, call 1-800-236-9933. Please visit www.azprivacynotice.com to review our Privacy Notice.

Enroll and continue

[H2] IMPORTANT SAFETY INFORMATION

TAGRISSO may cause serious side effects, including:

Lung problems. TAGRISSO may cause severe lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you have any new or worsening lung symptoms, including trouble breathing, shortness of breath, cough, or fever
Heart problems, including heart failure. TAGRISSO may cause heart problems that may lead to death. Your healthcare provider should check your heart function before you start taking TAGRISSO and during treatment as needed. Tell your healthcare provider right away if you have any of the following signs and symptoms of a heart problem: feeling like your heart is pounding or racing, shortness of breath, swelling of your ankles and feet, dizziness, feeling lightheaded, or feeling faint
Eye problems. TAGRISSO may cause eye problems. Tell your healthcare provider right away if you have symptoms of eye problems which may include watery eyes, sensitivity to light, eye pain, eye redness, or vision changes. Your healthcare provider may send you to see an eye specialist (ophthalmologist) if you get eye problems with TAGRISSO
Skin problems. TAGRISSO may cause skin problems. Tell your healthcare provider right away if you develop skin reactions that look like rings (target lesions), severe blistering or peeling of the skin
Inflammation of the blood vessels in your skin. TAGRISSO may cause blood vessel problems in your skin. Tell your healthcare provider right away if you develop purple spots or redness of the skin that does not fade in color when pressed (non-blanching) on your lower arms, lower legs, or buttocks or large hives on the main part of your body (trunk) that do not go away within 24 hours and look bruised
Blood and bone marrow problems. TAGRISSO may cause a condition where your bone marrow cannot make enough new blood cells (aplastic anemia), and which may lead to death. Your healthcare provider will monitor your blood cell counts before you start and during treatment with TAGRISSO. Tell your healthcare provider right away if you develop any signs and symptoms of blood and bone marrow problems, including a new fever or fever that does not go away (≥100.4 °F), easy bruising or bleeding that will not stop, unusually pale skin, infection, tiredness, or weakness

Before taking TAGRISSO, tell your healthcare provider about all of your medical conditions, including if you:

have lung or breathing problems other than your lung cancer
have heart problems, including a condition called long QTc syndrome
have problems with your electrolytes, such as sodium, potassium, calcium or magnesium
have a history of eye problems
are pregnant or plan to become pregnant. TAGRISSO can harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with TAGRISSO or think you may be pregnant

Females who are able to become pregnant should have a pregnancy test before starting treatment with TAGRISSO. You should use effective birth control (contraception) during treatment with TAGRISSO and for 6 weeks after the last dose of TAGRISSO
Males who have female partners that are able to become pregnant should use effective birth control during treatment with TAGRISSO and for 4 months after the last dose of TAGRISSO

females who are breastfeeding or plan to breastfeed. It is not known if TAGRISSO passes into your breast milk. Do not breastfeed during treatment with TAGRISSO and for 2 weeks after your last dose of TAGRISSO. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements. Especially tell your healthcare provider if you take a heart or blood pressure medicine
The most common side effects of TAGRISSO when given alone include:

low white blood cell counts
low platelet counts
low red blood cell counts (anemia)
diarrhea
rash
muscle, bone, or joint pain

changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
dry skin
mouth sores
tiredness

low white blood cell counts
low platelet counts
low red blood cell counts (anemia)
diarrhea
rash
muscle, bone, or joint pain
changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
dry skin
mouth sores
tiredness

The most common side effects of TAGRISSO when given alone after treatment with platinum-based chemotherapy and radiation treatment include:

low white blood cell counts
lung problems
low platelet counts
rash
diarrhea

changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
cough
COVID-19

low white blood cell counts
lung problems
low platelet counts
rash
diarrhea
changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
cough
COVID-19

The most common side effects of TAGRISSO in combination with pemetrexed and platinum-based chemotherapy include:

low white blood cell counts
low platelet counts
rash
diarrhea
mouth sores

changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail

dry skin
increase of a substance in the blood called creatinine

low white blood cell counts
low platelet counts
rash
diarrhea
mouth sores
changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from the nailbed, and shedding of nail
dry skin
increase of a substance in the blood called creatinine

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of TAGRISSO. For more information, ask your healthcare provider or pharmacist.
[H3] What is TAGRISSO?

TAGRISSO is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC) that has certain abnormal epidermal growth factor receptor (EGFR) gene(s):

to help prevent your lung cancer from coming back after your tumor(s) has been removed by surgery, or
when your lung cancer has spread to nearby tissues (locally advanced), that is unable to be removed (unresectable) by surgery and has responded or stabilized following chemotherapy and radiation treatment, or
as your first treatment when your lung cancer has spread to other parts of the body (metastatic), or
in combination with pemetrexed and platinum-based chemotherapy, as your first treatment when your lung cancer has spread to nearby tissues (locally advanced) or to other parts of the body (metastatic), or
when your lung cancer has spread to other parts of the body (metastatic) and you have had previous treatment with an EGFR tyrosine kinase inhibitor (TKI) medicine that did not work or is no longer working.

Your healthcare provider will perform a test to make sure that TAGRISSO is right for you.
It is not known if TAGRISSO is safe and effective in children.
Please see complete Prescribing Information, including Patient Information for TAGRISSO.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
You may report side effects related to AstraZeneca products
[IMG: link Icon]
.
EGFR is epidermal growth factor receptor; EGFR+ is epidermal growth factor receptor mutation-positive; NSCLC is non-small cell lung cancer.
EGFR+ is epidermal growth factor receptor mutation-positive; NSCLC is non-small cell lung cancer.

[H3]
IMPORTANT SAFETY INFORMATION

see-more

[H2] You are about to enter the TAGRISSOHCP.com site for Healthcare Professionals

The information in this site is intended for US Healthcare Professionals only.
CONTINUE

[H2] You are about to enter the TAGRISSONurse.com site for Healthcare Professionals

The information in this site is intended for US Healthcare Professionals only.
CONTINUE

[H2] Contact Us

General or Product Questions

If you are in the United States and would like additional information regarding AstraZeneca products, you can contact AstraZeneca by phone at 1-800-236-9933 (Monday - Friday 8 AM - 6 PM ET, excluding holidays). Outside these hours and on holidays, an after-hours service is available to assist with any urgent medical inquiries.

[IMG: TAGRISSO DTC Logo]

[IMG: TAGRISSO DTC Logo]

[H1] TAGRIS SOI can make pancakes

[H3]
Watch Deb’s story

[H3]

[H1] Understanding different
types of lung cancer

The two main types of lung cancer are non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). They are named based on how the cancer cells look under the microscope.

About 80% to 85% of all lung cancer cases are NSCLC, making it the most common type of lung cancer

It’s important to know your NSCLC stage
[IMG: NSCLC Stage-1]
Click the bar to see the different stages

[IMG: NSCLC Stage-1]

[IMG: NSCLC Stage-1]
Stage 1Cancer is located only in the lungs and has not spread to any lymph nodes. The tumor is no larger than a few centimeters

[IMG: NSCLC Stage-2]
Stage 2Cancer is in the lungs and may have spread to nearby lymph nodes on the same lung

[IMG: NSCLC Stage-3]
Stage 3Cancer is in the lungs and may have spread to the lymph nodes. There may now be separate tumors on the same lung where the cancer started

[IMG: NSCLC Stage-4]
Stage 4Unlike the earlier stages of lung cancer, stage 4 lung cancer has spread to parts of the body beyond the lungs (metastatic). The tumors may be of any size and may or may not have spread to lymph nodes

Your doctor will perform tests to determine your lung cancer stage. Please speak to your doctor to learn more about what your stage of lung cancer means for you.
If you have stage 4 (metastatic) NSCLC, click here.

[IMG: NSCLC Stage-1]

[IMG: NSCLC Stage-4]
Stage 1Cancer is located only in the lungs and has not spread to any lymph nodes. The tumor is no larger than a few centimeters

[IMG: NSCLC Stage-2]
Stage 2Cancer is in the lungs and may have spread to nearby lymph nodes on the same lung

[IMG: NSCLC Stage-3]
Stage 3Cancer is in the lungs and may have spread to the lymph nodes. There may now be separate tumors on the same lung where the cancer started

[IMG: NSCLC Stage-4]
Stage 4Unlike the earlier stages of lung cancer, stage 4 lung cancer has spread to parts of the body beyond the lungs (metastatic). The tumors may be of any size and may or may not have spread to lymph nodes

Your doctor will perform tests to determine your lung cancer stage. Please speak to your doctor to learn more about what your stage of lung cancer means for you.
If you have stage 4 (metastatic) NSCLC, click here.

[H3] When diagnosed at an earlier stage (stage 1-3)

Some earlier stages of cancer can be treated with surgery. If a tumor is considered “resectable,” it means that your cancer may be removed from your body through surgery.

Depending on how much your cancer has spread in your lung, your surgeon may remove a portion of your lung (lobectomy), an entire lung (pneumonectomy), and/or any lymph nodes that are also affected

Be sure to talk to your doctor about any questions you may have. You can also find additional information here.

Why is it important to talk to your healthcare team about a treatment plan after surgery?
Even after a successful surgery, cancer may sometimes return months or years later. This is called a “disease recurrence.” However, there are therapies available that may help prevent your cancer from coming back.

[H3] Risk of cancer coming back (recurrence)

Surgery removes all of the tumor that can be seen, plus a small amount around the border of the tumor. Lymph nodes may also be removed.

Unfortunately, by the time you have surgery, individual cancer cells may have already moved to other sites in the body. These cells may be too few to be detected by any tests, and, if left alone, may multiply and cause the cancer to come back. These cells are called "micrometastasis"
Treatment after surgery is meant to reach these cells even though they cannot be seen

Having your doctor test your tumor may give them important information they need to determine a treatment plan that may help prevent your cancer from returning after surgery

[H5] Your tumor that was removed during surgery can be tested for something called biomarkers. Find out about biomarkers and biomarker testing below.

[IMG: What is Biomarker Test]
[IMG: What is Biomarker Test]

What is a “biomarker” test?

[H3]

[H3] Not all lung cancers are the same

Biomarker testing can reveal mutations (sometimes called biomarkers) present in your type of lung cancer that may be causing your cancer to grow and spread. Testing for biomarkers is a way for your healthcare team to determine appropriate treatment options.
Biomarker testing can be done by performing a biopsy (where a small piece of tissue is removed from the tumor). Your doctor may have already taken a biopsy prior to the surgery to remove your tumor to learn more information about your type of lung cancer.
If you have already had surgery to remove your tumor, your surgical sample could also be used for biomarker testing, meaning that no further invasive procedure would be required. You will simply need to have a conversation with your doctor and provide consent to test your sample post-surgery for biomarkers.
Biomarker testing can be done at the time of diagnosis or any time throughout your treatment journey.
[H3] Biomarkers can reveal detailed information, including:

[IMG: Lungs Icon]
what may be causing your cancer to grow and spread

[IMG: Pills Icon]
which types of treatment may be appropriate for your type of cancer

[H3] People with early-stage NSCLC may have a biomarker that could be targeted with therapy

There are many NSCLC biomarkers, but some are more common than others. Your doctor may recommend you be tested for biomarkers such as EGFR mutation.
Certain types of biomarker testing are sometimes referred to as genomic testing, molecular testing, or mutation testing.
Finding out if your tumor tests positive for a biomarker, like an EGFR mutation, may help your doctor determine an appropriate treatment plan for your type of lung cancer.

[IMG: Medical Oncologist]

[IMG: Medical Oncologist]

Biomarker testing is done by a medical oncologist
A medical oncologist is a doctor who treats cancer with medicine

Based on your biomarker test results, your medical oncologist may recommend a treatment plan designed to treat your type of cancer

It's important to get biomarker testing to help you and your doctor determine the appropriate treatment plan.

Biomarker testing is done by a medical oncologist
A medical oncologist is a doctor who treats cancer with medicine

Based on your biomarker test results, your medical oncologist may recommend a treatment plan designed to treat your type of cancer

It's important to get biomarker testing to help you and your doctor determine the appropriate treatment plan.

[H5] Ask your surgeon for a referral to a medical oncologist to ensure you’re doing everything you can to get the right care for your lung cancer. Make sure to always follow through on your referral.

Epidermal Growth Factor Receptor (EGFR) is a common and important mutation
Epidermal Growth Factor Receptor (EGFR) is a common and important mutation
[H3] Non-small cell lung cancer with an EGFR mutation is known as EGFR+ NSCLC. EGFR is a mutation that is found in some people with early-stage NSCLC.

[IMG: NSCLC Patients Stage]

About 1 in 5
people with stage 1-3 NSCLC have cancer that tests positive for an EGFR mutation*

EGFR is important because, when it is mutated, it can cause lung cancer to grow and spread.

*Prevalence of EGFR mutations in NSCLC adenocarcinoma was based on data from 2 references: Sholl et al (2015) performed mutation analysis on 1007 cases with confirmed diagnosis of lung adenocarcinoma. Testing was performed on 987 cases for EGFR sensitizing mutations (exon 19 deletions, EGFR L858R mutations, EGFR G719X mutations, EGFR L861Q mutations) and other EGFR mutations (any one or more mutations in EGFR other than exon 19 deletions, L858R mutations, G719X mutations, or L861Q mutations). Out of 987 cases, 331 cases that were analyzed had stage 1-3 NSCLC; and D’Angelo et al (2012) analyzed tumor specimens from a cohort of 1118 patients with stage I-III surgically resected lung adenocarcinomas with EGFR exon 19 deletions and L858R mutations only.
*Based on 2 studies: The first study included 1007 cases of lung cancer. They tested 987 cases for specific EGFR mutations and other mutations in the EGFR gene. Out of those 987 cases, 331 had stage 1-3 NSCLC. The second study analyzed tumors that were surgically removed from 1118 patients with stage 1-3 NSCLC for specific EGFR mutations.
About 1 in 5
people with stage 1-3 NSCLC have cancer that tests positive for an EGFR mutation*
[IMG: NSCLC Patients Stage]

EGFR is important because, when it is mutated, it can cause lung cancer to grow and spread.
*Prevalence of EGFR mutations in NSCLC adenocarcinoma was based on data from 2 references: Sholl et al (2015) performed mutation analysis on 1007 cases with confirmed diagnosis of lung adenocarcinoma. Testing was performed on 987 cases for EGFR sensitizing mutations (exon 19 deletions, EGFR L858R mutations, EGFR G719X mutations, EGFR L861Q mutations) and other EGFR mutations (any one or more mutations in EGFR other than exon 19 deletions, L858R mutations, G719X mutations, or L861Q mutations). Out of 987 cases, 331 cases that were analyzed had stage 1-3 NSCLC; and D’Angelo et al (2012) analyzed tumor specimens from a cohort of 1118 patients with stage I-III surgically resected lung adenocarcinomas with EGFR exon 19 deletions and L858R mutations only.
*Based on 2 studies: The first study included 1007 cases of lung cancer. They tested 987 cases for specific EGFR mutations and other mutations in the EGFR gene. Out of those 987 cases, 331 had stage 1-3 NSCLC. The second study analyzed tumors that were surgically removed from 1118 patients with stage 1-3 NSCLC for specific EGFR mutations.

[H5] Ask your doctors about biomarker testing today

Knowing your biomarker test results helps your doctor determine what treatment may be appropriate for you
Based on your biomarker test results, your medical oncologist may recommend one or more of the following treatments:

[IMG: Pills Icon]
Targeted therapy
A medication that is designed to target a specific feature of certain cancer cells
[IMG: Chemotherapy]
Chemotherapy
A treatment that works to interrupt the growth and division of cancer cells

[IMG: Chemotherapy-1]
Immunotherapy
A treatment that works to help the immune system identify and defend against cancer cells
[IMG: Radiation Icon]
Radiation
A kind of treatment that uses high-energy rays or waves aimed at one part of your body to stop cancer cells from growing and dividing

Follow-up
Your doctor will likely schedule follow-up appointments and imaging to monitor you

Knowing your biomarker test results helps determine what treatment is appropriate for you
Based on your biomarker test results, your medical oncologist may recommend one or more of the following treatments:

[IMG: Pills Icon]
Targeted therapy
A medication that is designed to target a specific feature of certain cancer cells
[IMG: Chemotherapy-1]
Chemotherapy
A treatment that works to interrupt the growth and division of cancer cells

[IMG: Chemotherapy]
Immunotherapy
A treatment that works to help the immune system identify and defend against cancer cells
[IMG: Radiation Icon]
Radiation
A kind of treatment that uses high-energy rays or waves aimed at one part of your body to stop cancer cells from growing and dividing

Follow-up
Your doctor will likely schedule follow-up appointments and imaging to monitor you

Recognize the importance of knowing all your test results before starting on treatment
Recognize the importance of knowing all your test results before starting on treatment
It might feel like you need to begin treatment right away but choosing the appropriate treatment plan for you takes time. It may take a few weeks for your doctor to get your results after the tissue sample is sent out for testing.
[H5] “Inspirational patient quote to come”

“Inspirational
patient quote
to come”
—Name X.

[H5] If your cancer tests positive for an EGFR mutation, you may be eligible for a targeted therapy like TAGRISSO.

Download a helpful brochure here

[IMG: Questions To Ask Icon]

Questions to ask
your healthcare team about your diagnosis

[IMG: Stage 6]

[H4] Are the biomarker test results being used to help determine the appropriate treatment plan for me?

[IMG: Number 1 icon]

[H4] What tests will I need to have to determine the stage of my cancer?

[IMG: Stage 2]

[H4] What stage is my lung cancer? What does this mean?

[IMG: Stage 1]

[H4] What tests will I need to have to determine the stage of my cancer?

[IMG: Number 2 icon]

[H4] What stage is my lung cancer? What does this mean?

[IMG: Stage 3]

[H4] How did you determine my lung cancer’s stage?

[IMG: Stage 2]

[H4] Wha

[H1] TAGRIS SOI can make pancakes

[H3]
Watch Deb’s story

[H3]

[H1] Support is in reach

We give you more than information. We encourage you to learn more about some of the world’s leading cancer organizations committed to informing, empowering, and building communities through a broad range of programs and resources.

[H3] Guide to understanding TAGRISSO

[IMG: TAGRISSO Informational Brochure]
TAGRISSO Informational Brochure
Download this brochure if you’ve been diagnosed with EGFR+ NSCLC following surgery and are getting ready to start treatment with TAGRISSO.
Available in other languages:
Filipino (Ilocano) | Spanish (Español)

Download
[IMG: Download arrow icon]

[IMG: Were you prescribed TAGRISSO?]
Were you prescribed TAGRISSO? Your doctor may have reviewed this guide with you during your appointment. You can download a digital copy here

Download
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Sign up for a free information kit on diagnosis and treatment.

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Patient Guide for Surgery

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Is TAGRISSO right for you?
Dr Sarada Gurubhagavatula explains what people should know about TAGRISSO® (osimertinib)

[H3] Watch Elise’s Story

Elise shares her early stage EGFR+ NSCLC story and why she's taking TAGRISSO

[H3]
Watch Elise’s Story

Elise shares her early stage EGFR+ NSCLC story and why her doctor prescribed TAGRISSO

Caregiver Resources
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What to Ask Your Care Team
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Caregiving for a loved one with lung cancer
When your loved one is diagnosed with lung cancer, you want to support them the best you can. You don’t have to do everything for them, and your support can take many different forms. Here are a couple of strategies and resources for taking care of your loved ones with lung cancer while also taking care of yourself.

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Know the disease
Understanding your loved one’s disease will not only show you care but may also take a load off their shoulders. For example, a person with early-stage NSCLC often has different needs than a person with stage 4 NSCLC. Knowing those needs can help you support them better. You may want to read some of the most Frequently Asked Questions about lung cancer to gain a better understanding of their condition.

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[H3] How to best support your loved one with NSCLC

Ask for a referral to a medical oncologist and follow through with the appointment

An oncologist may be able to determine an appropriate treatment plan that may help keep their cancer from coming back. Early-stage NSCLC is often treated first with surgery, but for some patients, surgery won’t be the end of their treatment journey. Help ensure that your loved one is referred to an oncologist to help create an appropriate treatment plan, and make sure to always follow through on your referral with your healthcare team

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Surgeon

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Medical Oncologist

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Pulmonologist

[H4] Pathologist

[H4] Radiation Oncologist

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Remind your loved one to find out their biomarker test results before starting treatment
A biomarker test measures “drivers” that may cause your loved one’s cancer to grow or spread and can be anything that is tested for or measured in the body as a sign of a medical condition or disease. Biomarkers can help doctors find out detailed information about a tumor and can help predict how well the body may respond to certain types of treatment. It is important to remember that test results may not come back for a few weeks, but it’s important to know the results before starting treatment. If your loved one has a biomarker like an EGFR mutation, their doctor may be able to create a targeted treatment plan designed for their kind of lung cancer

Support and encourage your loved one throughout treatment

Taking a medication as prescribed by their doctor is so important. Help remind them to take TAGRISSO once-daily, with or without food, about the same time every day, for as long as their doctor has prescribed it (for up to 3 years or if their cancer comes back or if they or their doctor decides to stop treatment)

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Support and encourage your loved one throughout treatment

Taking a medication as prescribed by their doctor is so important. Help remind them to take TAGRISSO once-daily, with or without food, about the same time every day, for as long as their doctor has prescribed it (for up to 3 years or if their cancer comes back or if they or their doctor decides to stop treatment)

“Inspirational caregiver quote to come”
—Name X.

Hear a real patient's story
Tackling appointments together
Doctor appointments can be overwhelming, especially if you’re living with cancer.

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[H3] Taking notes

Help your loved one by taking notes at their appointment or writing down questions they have before their appointment.

[H3] Coordinating rides

You can help someone with cancer get to the hospital whether that means driving them yourself, sending a gift card for a ridesharing app, or finding another friend or family member to drive them to their appointment.

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[H3] Following up

Checking in with your loved one after an appointment can be just as important as being there physically. You can set reminders on your phone to give them a call or text to see how they’re doing, or if they just want to talk.

Emotional and practical support
Living with lung cancer can take an emotional toll, and you can help support them in many ways.

Offer specific help. Any type of help is appreciated, but for someone with cancer, specific offers are the most helpful. Not having to think about delegating tasks can make a huge difference. Whether they need help with household errands, shopping, or other tasks, your support will have a positive impact on their life.
Make sure they have what they need. With time spent in and out of doctors’ offices, small items can help. Whether it’s a sweater, a portable phone charger, hand lotion, or a book for the waiting room—you can make sure they have what they need. Think about your loved one and find a small thing that could make a big difference in their day.
Include your loved one in activities. Doing things together can provide a sense of normalcy and help you both stay connected. Having fun together is essential when you’re living through stressful situations.

Get connected
with community
[H3] Both you and your loved one with cancer can benefit from getting connected to a community that can understand what you’re going through.

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Join a support network. Cancer survivors are a great resource for answering questions and possibly offering firsthand advice.

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Join the TAGRISSO Facebook community. Find support, share your experiences, and interact with people like you who are caring for someone who is living with EGFR+ NSCLC.

Get connected with community
Both you and your loved one with cancer can benefit from getting connected to a community that can understand what you’re going through.

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Join a support network. Cancer survivors are a great resource for answering questions and possibly offering firsthand advice.

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Join the TAGRISSO Facebook community. Find support, share your experiences, and interact with people like you who are caring for someone who is living with EGFR+ NSCLC.

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Take care of yourself
Take time for you.
Your own mental, physical, and emotional well-being is key to supporting your loved one. Taking short breaks and doing things you enjoy can help make you a more effective caregiver.
[H3] Express yourself.

It’s normal for you to feel a wide range of feelings. Talking about how you feel with other people caring for a loved one with cancer can help you manage your emotions.

[H4] When caring for a loved one with cancer, you may feel overwhelmed with questions

Get answers to Frequently
Asked Questions
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Financial support
No one can deny the financial burden a cancer diagnosis can take. For more information on how AstraZeneca can support those living with cancer, please call 1-844-ASK-A360 (1-844-275-2360) Monday through Friday, 8 AM - 6 PM ET or visit www.MyAccess360.com.
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Learn more
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Lung Cancer Advocacy
[H3] Information and tools from lung cancer advocacy organizations

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Learn more about NSCLC
GO2 for Lung Cancer has information about NSCLC, diagnostic testing, and types of treatments.

Learn
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Create a lung cancer care plan
My Lung Cancer Care Plan, developed by the Lung Cancer Research Foundation, is helpful for discussions with your doctors. You can keep track of information about your diagnosis, treatments, doctor appointments, and symptoms.

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LUNGevity offers curated expert videos and resources on the EGFR Patient Gateway to help you navigate your lung cancer diagnosis.

Explore
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[H4] Curious about a larger NSCLC community created with you in mind?

Get inspired to take action

[H2] IMPORTANT SAFETY INFORMATION

TAGRISSO may cause serious side effects, including:

Lung problems. TAGRISSO may cause severe lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you have any new or worsening lung symptoms, including trouble breathing, shortness of breath, cough, or fever
Heart problems, including heart failure. TAGRISSO may cause heart problems that may lead to death. Your healthcare provider should check your heart function before you start taking TAGRISSO and during treatment as needed. Tell your healthcare provider right away if you have any of the following signs and symptoms of a heart problem: feeling like your heart is pounding or racing, shortness of breath, swelling of your ankles and feet, dizziness, feeling lightheaded, or feeling faint
Eye problems. TAGRISSO may cause eye problems. Tell your healthcare provider right away if you have symptoms of eye problems which may include watery eyes, sensitivity to light, eye pain, eye redness, or vision changes. Your healthcare provider may send you to see an eye specialist (ophthalmologist) if you get eye problems with TAGRISSO
Skin problems. TAGRISSO may cause skin problems. Tell your healthcare provider right away if you develop skin reactions that look like rings (target lesions), severe blistering or peeling of the skin
Inflammation of the blood vessels in your skin. TAGRISSO may cause blood vessel problems in your skin. Tell your healthcare provider right away if you develop purple spots or redness of the skin that does not fade in color when pressed (non-blanching) on your lower arms, lower legs, or buttocks or large hives on the main part of your body (trunk) that do not go away within 24 hours and look bruised
Blood and bone marrow problems. TAGRISSO may cause a condition where your bone marrow cannot make enough new blood cells (aplastic anemia), and which may lead to death. Your healthcare provider will monitor your blood cell counts before you start and during treatment with TAGRISSO. Tell your healthcare provider right away if you develop any signs and symptoms of blood and bone marrow problems, including a new fever or fever that does not go away (≥100.4 °F), easy bruising or bleeding that will not stop, unusually pale skin, infection, tiredness, or weakness

Before taking TAGRISSO, tell your healthcare provider about all of your medical conditions, including if you:

have lung or breathing problems other than your lung cancer
have heart problems, including a condition called long QTc syndrome
have problems with your electrolytes, such as sodium, potassium, calcium or magnesium
have a history of eye problems
are pregnant or plan to become pregnant. TAGRISSO can harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with TAGRISSO or think you may be pregnant

Females who are able to become pregnant should have a pregnancy test before starting treatment with TAGRISSO. You should use effective birth control (contraception) during treatment with TAGRISSO and for 6 weeks after the last dose of TAGRISSO
Males who have female partners that are able to become pregnant should