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[H1] The leader in mass spectrometry
and capillary electrophoresis solutions
There, where it counts. Time and time again. Providing the precision detection and quantitation of molecules needed for scientists to make discoveries that change the world.

Our products

[IMG: ASMS 2026]

[IMG: Built for Business Impact]

ZenoTOF 7600 system
Discover Zeno trap and EAD. A powerful combination of MS/MS sensitivity and fragmentation technology.

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SCIEX OS software
Now suports Windows 11 to help labs meet internal and external IT security policies and reduces cybersecurity vulnerabilities for the lab ecosystem.

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Intabio ZT system
Be unstoppable with comprehensive charge variant analysis on a single system.

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[H2] Why SCIEX portfolio
Pioneering solutions that inspire life-changing research and revolutionize the industry.

Mass Spectrometers

Clinical Medical Devices

CE Instruments

HPLC MS

Software

Integrated Solutions

Technologies

Mass Spectrometers

[H3] Mass Spectrometers
SCIEX mass spectrometers are designed to help you break new ground by pushing the limits of speed and sensitivity in quantitative and qualitative analyses.

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Clinical Medical Devices

[H3] Clinical Medical Devices
Best-in-class in vitro diagnostic mass spec solutions that are extremely easy to adopt and powerful enough to handle the everyday demands of the clinical lab.

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CE Instruments

[H3] CE Instruments
Optimize your workflow efficiency with capillary electrophoresis systems that deliver exceeding sensitivity, resolution, and performance.

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HPLC MS

[H3] HPLC MS
The largest, most advanced range of front-end technologies to enhance the power of your mass spec, from analytical flow LC-MS to ultra-low flow CESI-MS.

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Software

[H3] Software
Intelligent, fast, secure, and intuitive software that delivers better results and meets the analytical needs of world’s most demanding labs.

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Integrated Solutions

[H3] Integrated Solutions
Integrated end-to-end mass spec workflows that give you everything you need to get the most out of your sample from start to finish.

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Technologies

[H3] Technology
SCIEX continues to revolutionize the industry with groundbreaking LC-MS/MS and capillary electrophoresis technology that influences life-changing research.

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[H2] Why SCIEX for your application

[H3] SCIEX Applications
SCIEX mass spec and capillary electrophoresis solutions are designed by scientists with your applications in mind. From routine testing to the most complex analytical experiments, we constantly innovate to enable you to transform your workflows.

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[H3] Clinical Diagnostics
Improve the quality of results, achieve faster turnaround times, and reduce costs. Routine diagnostic testing that delivers excellent accuracy and robust performance with our in vitro diagnostic medical device mass spectrometers

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[H3] Environmental Testing
Overcome complex matrices and measure more compounds in every sample. Our solutions deliver the lowest possible detection limits at trace levels with the ultimate accuracy.

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[H3] Food and Beverage Testing
Meet maximum residue limits (MRLs) with high-quality data that you can genuinely count upon. With SCIEX your lab can quickly and easily react to diverse market needs.

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[H3] Forensics Analysis
Accurately detect even the smallest compounds to deliver evidence that stands. Get fast, highly accurate data across a multitude of compounds and biomarkers.

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[H3] Life Science Research
Capture the best data, integrate results cross-omics, and gain relevant insights to make your next discovery. Get more reliable information on the key genes, proteins, lipids, and metabolites for your research.

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[H3] Pharma and BioPharma Research
Transform the capacity and capability of your biologics pipeline with innovative end-to-end mass spec and capillary electrophoresis solutions that help you to make better development decisions, faster.

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[H2] SCIEX Stories

A cast of thousands
A contract research organization in Colorado Springs works hard to get quality data for clients. Scientists at Aliri Bioanalysis help make drug products that result in better outcomes for patients.

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Pioneering future treatments
A focus on the patient is easy to see at Sutro Biopharma. Tyler Heibeck directs a team developing innovating cancer therapeutics that deliver better treatment options.

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[H5] SCIEX Now support network

[H5] The destination for all your support needs.

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Products

Mass Spectrometers

Overview

Benefits

Technology

Resources

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[H3]
Cut out risk, cut out information gaps.Gain multiple pieces of critical data up front.

Accelerate candidate selection by achieving separation,
quantitation, and direct identification of biopharmaceutical charge variants and their
proteoforms with icIEF-UV/MS via the Intabio ZT system.

“We need to look
at the data in totality.”

“Is this
candidate suitable for development?”

“What is the
reason we are seeing these peaks?”

Collect the data for
comprehensive charge variant ID in minutes not weeks.

[H4]
Comprehensive proteoform identification in minutes

The process of identifying individual charge variant components and interpreting their
structural differences conventionally takes weeks and requires the use of multiple
instruments, with multiple manual steps.

With the Intabio ZT system - separation, quantitation and identification of individual
charge variants can be achieved in minutes on a single platform.

Charge heterogeneity analysis

[H5] Contact SCIEX

[H5] Request more information to learn how the
Intabio ZT system can work for specific your needs.

Request
info

Request info

Request a
quote

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[H4]
Leverage key analytical functions with microfluidic chip-based technology

The Intabio ZT cartridge enables
key analytical functions using proprietary microfluidic chip-based integrated
icIEF-UV/MS technology.

Separation of charge variants with imaged capillary isoelectric focusing
(icIEF)
Quantitation with real-time UV detection
Electrospray ionization for further mass spectrometry identification

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Separation of charge
variants with imaged capillary isoelectric focusing (icIEF) and
quantitation with imaged UV detection occurs within the separation
channel

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To enable
electrospray ionization, electrolyte is introduced through the mobilizer
channel near the ESI tip, to re-ionize the charge variants.
The electric field is re-oriented to initiate the mobilization of the
peaks toward the electrospray
“ESI” tip.
This novel chemical mobilization process ensures that peak resolution is
maintained throughout MS
detection.

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Separated charge
variants are introduced to the mass spectrometer by electrospray
ionization
for peak identification.

[H3]
Eliminate the guess work with the ZenoTOF 7600 system

Enable a more detailed characterization approach by leveraging the enhanced
capabilities of the powerful ZenoTOF 7600 system with EAD fragmentation technology.

Explore the ZenoTOF 7600 system

[H3] Guide decisions with multidimensional analysis using the
Intabio ZT system

[H4]
Let Biologics Explorer software do the heavy lifting

Maintain data continuity with a
single workflow producing one, accessible dataset, where UV peaks correlate with
MS peaks. Let Biologics Explorer software do the heavy lifting with pre-built
workflows for charge variant analysis. Get the required information to make
confident decisions, fast.

Learn more

[H5] Contact SCIEX

[H5] Request more information to learn how the
Intabio ZT system can work for specific your needs.

Request
info

Request info

Request a
quote

Request a quote

[H4]
Separate, characterize, identify

High-throughput product quality
characterization with rapid multi-attribute monitoring of intact biotherapeutics
and identification of charge variants throughout the drug development pipeline.

01:

Acquire charge variant separation profiles in minutes

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[H3] Acquire charge
variant separation profiles in minutes

Support high throughput analysis with 15
minute separation and enable detailed
characterization on charge variant peaks of
multiple monoclonal antibodies without
redundant method development or fraction
collection.

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02:

Achieve highly confident critical quality attribute
identification

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[H3] Achieve highly
confident critical quality attribute identification

Identify common CQAs:

C-terminal lysine variants

Glycosylation

High mannose
Sialic acids

Deamidation
Glycation

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03:

Identify proteoforms that could impact product quality

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[H3]
Identify proteoforms that could impact product
quality

High-resolution separation and
Identification of proteoforms with as little
as 0.02 pI value difference.

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[H4]
Wherever you play in the pipeline, change the game in modern medicine

Clone selection, cell line development

Intact protein analysis, charge variant analysis, PTM
characterization

Process development

Charge variants, glycoforms, PQA assessment

Formulation

Stability/degradation

Manufacturing attribute monitoring

CQA and PQA monitoring

[H4]
Associated applications

[H5]
Charge variant analysis

Achieve the
full picture and accelerate decisions with comprehensive
characterization of biopharmaceutical charge variants.

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[H5]
Intact protein analysis

Confidently
select lead candidates and ensure reproducible product quality. Fast and
reliable protein analysis solutions that simplify identification and
characterization of complex molecules at the intact level.

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[H4] Featured resources

Technical note

Discover how to use the Intabio ZT system to develop a platform screening method for mAb based therapeutics.
An evaluation of an integrated icIEF-UV/MS platform method combined with EAD-based peptide mapping for rapid, high-confidence characterization of monoclonal antibodies (mAbs), demonstrating effective separation, detection, and identification of charge variants and post-translational modifications across four USP mAb standards with pI values from 7.3 to 9.6, Resolve subtle proteoform differences, confirm PTMs including glycation and reduced thiols, and reduce method development time while maintaining flexibility for optimization.

Technical note

Enhanced sensitivity to identify low abundant proteoforms
A 4x increase in sensitivity enables detection and confident identification of challenging proteoforms like deamidation

Technical note

Charge heterogeneity monitoring to comprehensive biotherapeutic characterization
Take full advantage of advanced characterization capabilities of the EAD enabled ZenoTOF 7600 system with simple conversion from icIEF-UV/MS to EAD based LC/MS.

Technical note

Enhance PQA identification during ADC development with confident proteoform ID, and payload localization.
Gain a level of characterization beyond traditional LC separation and CID based workflows to provide critical information to guide analytical strategies throughout ADC development.

Technical note

Confidently assign proteoforms and
low abundant charge variants without fraction collection
A single platform
icIEF-UV/MS workflow on the Intabio ZT system provides confident
identification of sialyated glycoproteins.

Service Plan

Intabio ZT system service plan

Designed to provide the
confidence you need to achieve your analytical goals.

Technical note

Leverage orthogonal technologies

Facilitate
biotherapeutics development with cIEF, icIEF-UV/MS and LC-MS.

Technical note

Explore an icIEF-UV/MS workflow for
charge variant analysis of antibody-drug conjugates
Learn about a novel
integrated workflow for your charge variant analysis of ADCs.

Technical note

Bring the precision of mass spec ID
to early development
Highly confident
identification of CQAs with an integrated icIEF-UV/MS solution that
identifies low abundant PTMs at the intact protein level.

Technical note

Reproducible separation and
identification of proteoforms
Gain advantages in data
quality and time with an integrated system that offers high-resolution and
high-throughput separation of intact mAbs and their charge variants.

Technical note

Separate, characterize, identify,
across a wide pI range
A single platform
icIEF-UV/MS workflow offers high sensitivity and selectivity to detect
low-abundant proteoforms that could impact product quality.

Technical note

Confidently identify glycation
events using icIEF-UV/MS
Comprehensive
characterization and identification of the charge variants of deglycosylated
NISTmAb in minutes.

On-demand webinar

Rapidly assess the impact of cell
culture conditions on mAb quality and production
Biopharmaceutical
product development is all about product knowledge, whether it be writing a
regulatory submission, investigating unexpected results, or performing
extended characterization.

On-demand webinar

Address the unexpected in cell line
development
Guide decisions during
cell line development with charge variant identification at the intact
level.

On-demand webinar

Gain multiple pieces of critical
data on complex biotherapeutics up front
Take a deep dive into
the characterization of charge variants on an ADC using icIEF-UV/MS.

Support

Professional laboratory services

[H2]
Professional laboratory services

At SCIEX, we offer a range of professional lab services to help our customers tackle their most pressing scientific challenges.

[H4] Overview

[H3] Expertise and professionalism your lab can rely on.
The SCIEX professional services team draws upon decades of experience from all aspects of life science workflows and laboratory environments. The vast level of expertise, attention to detail and care that is delivered throughout your project will be second to none. There are lots of key projects that the SCIEX Professional Services team can help you with to ensure your lab increases productivity, compliance attainment, instrument verification and relocation. Regardless of the task in hand the SCIEX Professional Service experts are your trusted partners in delivering laboratory and scientific excellence.

Explore our services
Explore our services

[H5] Customization
One size does not fit all. SCIEX professional services understands that all labs and workflows are different. Standards and regulations vary by region and updates may need to be applied to a system where all activities must be documented in a SOP record. You can trust that the team will bring the same level of support and commitment to a first-time request as to a reoccurring common procedure.

[H5] Experts
The SCIEX professional services consists of an extensive team of industry and system specialists who are focused on understanding and addressing the challenges you face and providing a clear path to a robust solution. Our expertise covers workflows, instrument configurations, method validations, compliance and more.

[H5] Budget
We understand that budgets are not infinite. The services and products we deliver will be sized accordinging to your labs needs and available budget. Timelines, can be sensitive and certain projects may need expediting. During the consultation phase of your project,  the team will work within your parameters to deliver the best tailored solution within your financial and time considerations.

[H5] Coverage
SCIEX professional services are not limited to mass spectrometry workflows. The team has proven experience across the entire SCIEX portfolio from capillary electrophoresis and software, including delivering a seamless transition from Analyst software to SCIEX OS software.

[H3] Bespoke solutions for your lab's needs
Laboratories are unique, there is not one set of services that can comprehensively support requirements, objectives and goals. The SCIEX professional services team offer customized solutions and services to help realise your lab’s ambition. The team offer the following:
Full consultation and evaluation of your needsImproved efficiencies and increased productivity Complete visibility into financial considerations for cost reductionResource support

As the team find out more about your needs and the scope of the work required you will receive a project pan with costings aligned to your budgets, along with an expected timeline. All this information is provided prior to the commencement of the project. If you would like to request SCIEX professional services then please follow the link below.

Request a quote
Request a quote

[H4] Our areas of expertise

[H5] Software and IT services
Integrating and optimizing the technology in your lab is ongoing. We can assist in maximizing automation to make your lab efficient and to mitigate risks of downtime and data loss. We specialize in the migration from Analyst to SCIEX OS software ensuring a seamless transition to the latest and most powerful software for your system.
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[H5] Lab compliance services
Regulatory compliance is at the core of success for your lab. Our certified SCIEX engineers guide you through installation qualification (IQ), operational qualification (OQ), performance qualification (PQ), and re-qualification.
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[H5] Lab optimization
Let our team of experts audit and assess your laboratory workflows and process strategies to unlock productivity potential in your lab. This optimization service will improve efficiencies of your labs which could help contribute to your operation's bottom line.
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[H5] Consulting and customized lab training
Lab staff turnover sometimes puts your workflow in a knowledge deficit. Support and training packages are available to improve onboarding and upskilling to drive productivity and system efficiencies. Training will enable consistency of your workflows, and system maintenance along with increased staff confidence and proficiency in operating your systems.
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[H5] Lab relocation services
Sometimes, you must move your systems from one room to another, or to another building, state or country. Regardless of your need, offers a relocation service that protects your system throughout its journey and reinstallation.
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