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Genentech (TECENTRIQ)
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HOMEPAGE Cancer Immunotherapy Treatment for NSCLC, ES-SCLC, HCC, & Advanced Melanoma | TECENTRIQ® (atezolizumab) (https://tecentriq.com)
Cancer Immunotherapy Treatment for NSCLC, ES-SCLC, HCC, & Advanced Melanoma | TECENTRIQ® (atezolizumab)
Learn about TECENTRIQ® (atezolizumab), a cancer Immunotherapy treatment for Non-Small Cell Lung Cancer after surgery and chemo, Metastatic Non-Small Cell Lung Cancer (NSCLC), Extensive-Stage Small Cell Lung Cancer (ES-SCLC), Liver cancer (HCC), & Advanced Melanoma | TECENTRIQ® (atezolizumab)
REPEATED_BODY Liver Cancer (HCC) Treatment | TECENTRIQ® (atezolizumab) (https://tecentriq.com/hcc.html)
Liver Cancer (HCC) Treatment | TECENTRIQ® (atezolizumab)
Find information about liver cancer treatment with TECENTRIQ® (atezolizumab) & Avastin® (bevacizumab). A treatment option for hepatocellular carcinoma (HCC). See full safety for more information.
REPEATED_BODY Extensive-Stage Small Cell Lung Cancer Treatment | TECENTRIQ® (atezolizumab) (https://tecentriq.com/sclc.html)
Extensive-Stage Small Cell Lung Cancer Treatment | TECENTRIQ® (atezolizumab)
Find out about TECENTRIQ® (atezolizumab) for the treatment of extensive-stage small cell lung cancer (ES-SCLC). See full safety for more information.
REPEATED_BODY Advanced Melanoma Treatment | TECENTRIQ® (atezolizumab) (https://tecentriq.com/melanoma.html)
Advanced Melanoma Treatment | TECENTRIQ® (atezolizumab)
Learn about TECENTRIQ® (atezolizumab) with COTELLIC® (cobimetinib) & ZELBORAF® (vemurafenib), an immunotherapy combination treatment that works together to treat advanced melanoma. See full safety for more information.
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HOMEPAGE (https://tecentriq.com) Cancer Immunotherapy Treatment for NSCLC, ES-SCLC, HCC, & Advanced Melanoma | TECENTRIQ® (atezolizumab)
[H1] TECENTRIQ MAY WORK WITH YOUR IMMUNE SYSTEM TO FIGHT CANCER PLEASE SELECT CANCER TYPE: PLEASE SELECT CANCER TYPE: [IMG: NSCLC Button] PD-L1+ Non-Small Cell Lung Cancer After Surgery + Chemo [IMG: Liver Cancer Button] Liver Cancer [IMG: SCLC Button] Extensive-Stage Small Cell Lung Cancer [IMG: Melanoma Button] Advanced Melanoma [IMG: NSCLC Button] Metastatic Non-Small Cell Lung Cancer PD-L1+ = positive for the biomarker called programmed death-ligand 1. [IMG: NSCLC Button] PD-L1+ Non-Small Cell Lung Cancer After Surgery + Chemo [IMG: SCLC Button] Extensive-Stage Small Cell Lung Cancer [IMG: NSCLC Button] Metastatic Non-Small Cell Lung Cancer [IMG: Liver Cancer Button] Liver Cancer [IMG: Melanoma Button] Advanced Melanoma PD-L1+ = positive for the biomarker called programmed death-ligand 1. TECENTRIQ may also affect normal cells. TECENTRIQ® (atezolizumab) is an immunotherapy designed to target and treat certain types of cancer, including PDL1+ non-small cell lung cancer after surgery and chemo (NSCLC), metastatic non-small cell lung cancer (mNSCLC), extensive-stage small cell lung cancer (ES-SCLC), hepatocellular carcinoma (HCC) that has spread or cannot be removed by surgery, and BRAF V600+ advanced melanoma. TECENTRIQ is different than traditional chemotherapy. It is a cancer immunotherapy and an anti-PD-L1 antibody, meaning it is designed to block PD-L1. By blocking PD-L1, TECENTRIQ is thought to reveal cancer cells. This process helps your immune system recognize, target, and attack your cancer. TECENTRIQ may also affect normal cells. TECENTRIQ is administered as infusions into a vein through an intravenous (IV) line. Severe side effects of TECENTRIQ include lung problems, intestinal problems, liver problems, hormone gland problems, kidney problems, skin problems, problems in other organs, severe infusion reactions, and complications including graft-versus-host disease (GVHD) in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). [H2] Important Safety Information and Indications Back to Top [H5] Indications What is TECENTRIQ? TECENTRIQ is a prescription medicine used to treat: Adults with a type of lung cancer called non-small cell lung cancer (NSCLC). TECENTRIQ may be used alone as a treatment for your lung cancer: to help prevent your lung cancer from coming back after your tumor(s) has been removed by surgery and you have received platinum-based chemotherapy, and you have stage 2 to stage 3A NSCLC (talk to your healthcare provider about what these stages mean), and your cancer tests positive for “PD-L1”. TECENTRIQ may be used alone as your first treatment when your lung cancer: has spread or grown, and your cancer tests positive for “high PD-L1”, and your tumor does not have an abnormal “EGFR” or “ALK” gene. TECENTRIQ may be used with the medicines bevacizumab, paclitaxel, and carboplatin as your first treatment when your lung cancer: has spread or grown, and is a type called “non-squamous NSCLC”, and your tumor does not have an abnormal “EGFR” or “ALK” gene. TECENTRIQ may be used with the medicines paclitaxel protein-bound and carboplatin as your first treatment when your lung cancer: has spread or grown, and is a type called “non-squamous NSCLC”, and your tumor does not have an abnormal “EGFR” or “ALK” gene. TECENTRIQ may be used alone when your lung cancer: has spread or grown, and you have tried chemotherapy that contains platinum, and it did not work or is no longer working. If your tumor has an abnormal “EGFR” or “ALK” gene, you should have also tried an FDA-approved therapy for tumors with these abnormal genes, and it did not work or is no longer working. Adults with a type of lung cancer called “extensive-stage small cell lung cancer (SCLC),” which is SCLC that has spread or grown: TECENTRIQ may be used with the chemotherapy medicines carboplatin and etoposide as your first treatment TECENTRIQ may be used with the medicine lurbinectedin as maintenance treatment when your lung cancer: has not progressed after first treatment with TECENTRIQ or atezolizumab and hyaluronidase-tqjs and the chemotherapy medicines carboplatin and etoposide. Adults with a type of liver cancer called hepatocellular carcinoma (HCC). TECENTRIQ may be used with the medicine bevacizumab when your liver cancer: has spread or cannot be removed by surgery, and you have not received other medicines by mouth or injection through your vein (IV) to treat your cancer. Adults with a type of skin cancer called melanoma. TECENTRIQ may be used with the medicines cobimetinib and vemurafenib when your melanoma: has spread to other parts of the body or cannot be removed by surgery, and has a certain type of abnormal “BRAF” gene. Your healthcare provider will perform a test to make sure this TECENTRIQ combination is right for you. It is not known if TECENTRIQ is safe and effective when used: In children for the treatment of NSCLC, SCLC, HCC or melanoma. What is the most important information about TECENTRIQ? TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended. Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including: Lung problems cough shortness of breath chest pain Intestinal problems diarrhea (loose stools) or more frequent bowel movements than usual stools that are black, tarry, sticky, or have blood or mucus severe stomach-area (abdomen) pain or tenderness Liver problems yellowing of your skin or the whites of your eyes severe nausea or vomiting pain on the right side of your stomach area (abdomen) dark urine (tea colored) bleeding or bruising more easily than normal Hormone gland problems headaches that will not go away or unusual headaches eye sensitivity to light eye problems rapid heartbeat increased sweating extreme tiredness weight gain or weight loss feeling more hungry or thirsty than usual urinating more often than usual hair loss feeling cold constipation your voice gets deeper dizziness or fainting changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness Kidney problems decrease in your amount of urine blood in your urine swelling of your ankles loss of appetite Skin problems rash itching skin blistering or peeling painful sores or ulcers in mouth or nose, throat, or genital area fever or flu-like symptoms swollen lymph nodes Problems can also happen in other organs. These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including: Chest pain, irregular heartbeat, shortness of breath, or swelling of ankles Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight Persistent or severe muscle pain or weakness, muscle cramps Low red blood cells, bruising Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking itching or rash flushing shortness of breath or wheezing dizziness feeling like passing out fever back or neck pain Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications. Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects. Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you: have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus have received an organ transplant have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic) have received radiation treatment to your chest area have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome are pregnant or plan to become pregnant. TECENTRIQ can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TECENTRIQ. Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with TECENTRIQ. You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of TECENTRIQ. are breastfeeding or plan to breastfeed. It is not known if TECENTRIQ passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of TECENTRIQ. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The most common side effects of TECENTRIQ when used alone include: feeling tired or weak decreased appetite nausea cough shortness of breath The most common side effects of TECENTRIQ when used in lung cancer with other anti-cancer medicines include: feeling tired or weak nausea hair loss constipation diarrhea decreased appetite The most common side effects of TECENTRIQ when used in hepatocellular carcinoma (HCC) with bevacizumab include: high blood pressure feeling tired or weak too much protein in the urine The most common side effects of TECENTRIQ when used in melanoma with cobimetinib and vemurafenib include: skin rash joint, muscle, or bone pain feeling tired or weak liver injury fever nausea itching swelling of legs or arms mouth swelling (sometimes with sores) low thyroid hormone levels sunburn or sun sensitivity TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility. These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555. Please see full Prescribing Information and Medication Guide for additional Important Safety Information. TOP
SUB-PAGE (https://tecentriq.com/hcc.html) Liver Cancer (HCC) Treatment | TECENTRIQ® (atezolizumab)
[H1] Morning catch-ups, continued TECENTRIQ + Avastin® (bevacizumab) is the first combination treatment for hepatocellular carcinoma (HCC) that can be used first-line* Learn how TECENTRIQ + Avastin may help *For HCC that has spread or cannot be removed by surgery. Actor portrayal [IMG: Question mark for doctor discussion guide] Make the most of your next visit Find helpful questions to ask your doctor [IMG: Video play icon] Learn about HCC & TECENTRIQ + Avastin from the experts Hear what they're saying [IMG: Financial assistance icon] Financial assistance options See if you're eligible [IMG: Shield star for veterans] [H5] Are you a veteran affected by HCC? Download some information, including how often veterans are diagnosed with HCC. Read about some common risk factors, and find helpful tips on how to talk to your doctor about treatment. Get information Our thanks go out to the individuals, families, and healthcare providers who participated in the clinical trial of TECENTRIQ for HCC. TECENTRIQ® (atezolizumab) is an FDA-approved immunotherapy used in combination with Avastin® (bevacizumab) to treat adults with hepatocellular carcinoma (HCC) that has spread or cannot be removed by surgery who have not received prior systemic therapy. TECENTRIQ is thought to work by targeting the PD-L1 protein, to help enhance the immune system’s ability to detect and attack cancer cells. TECENTRIQ may also affect normal cells. TECENTRIQ is administered as infusions into a vein through an intravenous (IV) line. TECENTRIQ can cause the immune system to attack normal organs and tissues in any area of the body and can affect the way they work. Serious side effects of TECENTRIQ may include, lung problems, intestinal problems, liver problems, hormone gland problems, kidney problems, skin problems, problems in other organs, severe infusion reactions, and complications including graft-versus-host disease (GVHD) in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). [H2] Important Safety Information and Indication Back to Top [H5] Indication What is TECENTRIQ? TECENTRIQ is a prescription medicine used to treat: Adults with a type of liver cancer called hepatocellular carcinoma (HCC). TECENTRIQ may be used with the medicine bevacizumab when your liver cancer: has spread or cannot be removed by surgery, and you have not received other medicines by mouth or injection through your vein (IV) to treat your cancer. It is not known if TECENTRIQ is safe and effective when used: in children for the treatment of HCC. What is the most important information about TECENTRIQ? TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended. Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including: Lung problems cough shortness of breath chest pain Intestinal problems diarrhea (loose stools) or more frequent bowel movements than usual stools that are black, tarry, sticky, or have blood or mucus severe stomach-area (abdomen) pain or tenderness Liver problems yellowing of your skin or the whites of your eyes severe nausea or vomiting pain on the right side of your stomach area (abdomen) dark urine (tea colored) bleeding or bruising more easily than normal Hormone gland problems headaches that will not go away or unusual headaches eye sensitivity to light eye problems rapid heartbeat increased sweating extreme tiredness weight gain or weight loss feeling more hungry or thirsty than usual urinating more often than usual hair loss feeling cold constipation your voice gets deeper dizziness or fainting changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness Kidney problems decrease in your amount of urine blood in your urine swelling of your ankles loss of appetite Skin problems rash itching skin blistering or peeling painful sores or ulcers in mouth or nose, throat, or genital area fever or flu-like symptoms swollen lymph nodes Problems can also happen in other organs. These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including: Chest pain, irregular heartbeat, shortness of breath, or swelling of ankles Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight Persistent or severe muscle pain or weakness, muscle cramps Low red blood cells, bruising Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking itching or rash flushing shortness of breath or wheezing dizziness feeling like passing out fever back or neck pain Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications. Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects. Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you: have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus have received an organ transplant have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic) have received radiation treatment to your chest area have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome are pregnant or plan to become pregnant. TECENTRIQ can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TECENTRIQ. Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with TECENTRIQ. You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of TECENTRIQ. are breastfeeding or plan to breastfeed. It is not known if TECENTRIQ passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of TECENTRIQ. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The most common side effects of TECENTRIQ when used in hepatocellular carcinoma (HCC) with bevacizumab include: high blood pressure feeling tired or weak too much protein in the urine TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility. These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555. Please see full TECENTRIQ Prescribing Information and full Avastin Prescribing Information for additional Important Safety Information. TOP
SUB-PAGE (https://tecentriq.com/sclc.html) Extensive-Stage Small Cell Lung Cancer Treatment | TECENTRIQ® (atezolizumab)
[H1] Weekends In The Workshop, Continued. If you have extensive-stage small cell lung cancer (ES-SCLC), small moments mean so much. Learn about your options with TECENTRIQ. See the different ways TECENTRIQ may help [IMG: Questions to ask your doctor] [H2] Talking to your doctor about TECENTRIQ Make the most of your next visit [IMG: How TECENTRIQ® (atezolizumab) is given] [H2] How TECENTRIQ is given Learn about the infusion process [IMG: Financial assistance options] [H2] Financial assistance options See if you're eligible Our gratitude goes out to the individuals, families, and healthcare providers who participated in the TECENTRIQ clinical trials for ES-SCLC. TECENTRIQ® (atezolizumab), in combination with the chemotherapy medicines carboplatin and etoposide, is an FDA-approved immunotherapy for adult patients with extensive-stage small cell lung cancer (ES-SCLC). Additionally, TECENTRIQ is FDA-approved in combination with the medicine lurbinectedin as maintenance treatment for adult patients with ES-SCLC who have not progressed after treatment with TECENTRIQ with carboplatin and etoposide. TECENTRIQ is thought to work by targeting the PD-L1 protein to enhance the immune response, helping the body detect and attack cancer cells. TECENTRIQ may also affect normal cells. TECENTRIQ is administered as infusions into a vein through an intravenous (IV) line. TECENTRIQ can cause the immune system to attack normal organs and tissues in any area of the body and can affect the way they work. Serious side effects of TECENTRIQ may include lung problems, intestinal problems, liver problems, hormone gland problems, kidney problems, skin problems, problems in other organs, severe infusion reactions, and complications including graft-versus-host disease (GVHD) in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). [H2] Important Safety Information and Indication Back to Top [H5] Indication What is TECENTRIQ? TECENTRIQ is a prescription medicine used to treat: Adults with a type of lung cancer called “extensive-stage small cell lung cancer (SCLC),” which is SCLC that has spread or grown TECENTRIQ may be used with the chemotherapy medicines carboplatin and etoposide as your first treatment TECENTRIQ may be used with the medicine lurbinectedin as maintenance treatment when your lung cancer: has not progressed after first treatment with TECENTRIQ or atezolizumab and hyaluronidase-tqjs and the chemotherapy medicines carboplatin and etoposide. It is not known if TECENTRIQ is safe and effective when used: in children for the treatment of SCLC What is the most important information about TECENTRIQ? TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended. Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including: Lung problems cough shortness of breath chest pain Intestinal problems diarrhea (loose stools) or more frequent bowel movements than usual stools that are black, tarry, sticky, or have blood or mucus severe stomach-area (abdomen) pain or tenderness Liver problems yellowing of your skin or the whites of your eyes severe nausea or vomiting pain on the right side of your stomach area (abdomen) dark urine (tea colored) bleeding or bruising more easily than normal Hormone gland problems headaches that will not go away or unusual headaches eye sensitivity to light eye problems rapid heartbeat increased sweating extreme tiredness weight gain or weight loss feeling more hungry or thirsty than usual urinating more often than usual hair loss feeling cold constipation your voice gets deeper dizziness or fainting changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness Kidney problems decrease in your amount of urine blood in your urine swelling of your ankles loss of appetite Skin problems rash itching skin blistering or peeling painful sores or ulcers in mouth or nose, throat, or genital area fever or flu-like symptoms swollen lymph nodes Problems can also happen in other organs. These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including: Chest pain, irregular heartbeat, shortness of breath, or swelling of ankles Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight Persistent or severe muscle pain or weakness, muscle cramps Low red blood cells, bruising Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking itching or rash flushing shortness of breath or wheezing dizziness feeling like passing out fever back or neck pain Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications. Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects. Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you: have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus have received an organ transplant have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic) have received radiation treatment to your chest area have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome are pregnant or plan to become pregnant. TECENTRIQ can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TECENTRIQ. Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with TECENTRIQ. You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of TECENTRIQ. are breastfeeding or plan to breastfeed. It is not known if TECENTRIQ passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of TECENTRIQ. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The most common side effects of TECENTRIQ when used in lung cancer with other anti-cancer medicines include: feeling tired or weak nausea hair loss constipation diarrhea decreased appetite TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility. These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555. Please see full Prescribing Information and Medication Guide for additional Important Safety Information. TOP
SUB-PAGE (https://tecentriq.com/melanoma.html) Advanced Melanoma Treatment | TECENTRIQ® (atezolizumab)
[H1] Bedtime Rituals… If you are an adult with BRAF V600+ advanced melanoma, small moments mean so much. TECENTRIQ immunotherapy with COTELLIC® (cobimetinib) and ZELBORAF® (vemurafenib) may be an option for you. Learn how TECENTRIQ may help [IMG: How TECENTRIQ® (atezolizumab) with COTELLIC® (cobimetinib) and ZELBORAF® (vemurafenib) are thought to work.] [H2] How TECENTRIQ with COTELLIC and ZELBORAF are thought to work Learn more [IMG: Dosing and administration] [H2] The dosing and administration process Learn about dosing [IMG: Financial assistance options.] [H2] Financial assistance options See if you're eligible TECENTRIQ® (atezolizumab) is an FDA-approved immunotherapy designed to treat adults with BRAF V600+ advanced melanoma. Treatment will consist of TECENTRIQ, along with COTELLIC® (cobimetinib) and ZELBORAF® (vemurafenib). Healthcare providers will administer the TECENTRIQ infusion into your vein through an intravenous (IV) line. COTELLIC and ZELBORAF are taken orally. TECENTRIQ is thought to work by targeting the PD-L1 protein, helping to enhance the immune system’s ability to detect and attack melanoma cells. TECENTRIQ may also affect normal cells. TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. Serious side effects of TECENTRIQ may include, lung problems, intestinal problems, liver problems, hormone gland problems, kidney problems, skin problems, problems in other organs, severe infusion reactions, and complications including graft-versus-host disease (GVHD) in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). [H2] Indication and Important Safety Information Back to Top [H5] Indication What is TECENTRIQ? TECENTRIQ is a prescription medicine used to treat: Adults with a type of skin cancer called melanoma. TECENTRIQ may be used with the medicines cobimetinib and vemurafenib when your melanoma: has spread to other parts of the body or cannot be removed by surgery, and has a certain type of abnormal “BRAF” gene. Your healthcare provider will perform a test to make sure this TECENTRIQ combination is right for you. It is not known if TECENTRIQ is safe and effective when used: In children for the treatment of melanoma. What is the most important information about TECENTRIQ? TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended. Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including: Lung problems cough shortness of breath chest pain Intestinal problems diarrhea (loose stools) or more frequent bowel movements than usual stools that are black, tarry, sticky, or have blood or mucus severe stomach-area (abdomen) pain or tenderness Liver problems yellowing of your skin or the whites of your eyes severe nausea or vomiting pain on the right side of your stomach area (abdomen) dark urine (tea colored) bleeding or bruising more easily than normal Hormone gland problems headaches that will not go away or unusual headaches eye sensitivity to light eye problems rapid heartbeat increased sweating extreme tiredness weight gain or weight loss feeling more hungry or thirsty than usual urinating more often than usual hair loss feeling cold constipation your voice gets deeper dizziness or fainting changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness Kidney problems decrease in your amount of urine blood in your urine swelling of your ankles loss of appetite Skin problems rash itching skin blistering or peeling painful sores or ulcers in mouth or nose, throat, or genital area fever or flu-like symptoms swollen lymph nodes Problems can also happen in other organs. These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including: Chest pain, irregular heartbeat, shortness of breath, or swelling of ankles Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight Persistent or severe muscle pain or weakness, muscle cramps Low red blood cells, bruising Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking itching or rash flushing shortness of breath or wheezing dizziness feeling like passing out fever back or neck pain Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications. Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects. Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you: have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus have received an organ transplant have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic) have received radiation treatment to your chest area have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome are pregnant or plan to become pregnant. TECENTRIQ can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TECENTRIQ. Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with TECENTRIQ. You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of TECENTRIQ. are breastfeeding or plan to breastfeed. It is not known if TECENTRIQ passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of TECENTRIQ. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The most common side effects of TECENTRIQ when used in melanoma with cobimetinib and vemurafenib include: skin rash joint, muscle, or bone pain feeling tired or weak liver injury fever nausea itching swelling of legs or arms mouth swelling (sometimes with sores) low thyroid hormone levels sunburn or sun sensitivity TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility. These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555. Please see full Prescribing Information and Medication Guide for additional Important Safety Information. TOP
🛡️ Trust Signals — reviews, proof links, trust-theatre flag (Trust & Proof)
| Page | Reviews | Proof links |
|---|---|---|
| / (home) | 2 | 0 |
| /hcc.html | 2 | 0 |
| /sclc.html | 2 | 0 |
| /melanoma.html | 2 | 0 |
🔗 Identity & Technical Layer — schema JSON-LD: identity chains, entity gaps (Identity & Authority)
Homepage schema
{
"@context": "http://schema.org",
"@type": "Organization",
"name": "Genentech",
"url": "https://www.gene.com/",
"logo": "https://www.gene.com/assets/frontend/img/Genentech_logo.png",
"description": "Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases.",
"contactPoint": {
"@type": "ContactPoint",
"telephone": "+1-877-436-3683",
"contactType": "customer service"
},
"address": {
"@type": "PostalAddress",
"streetAddress": "1 DNA Way",
"addressLocality": "South San Francisco",
"addressRegion": "California",
"postalCode": "94080",
"addressCountry": "US"
}
}
/hcc.html
{
"@context": "http://schema.org",
"@type": "Organization",
"name": "Genentech",
"url": "https://www.gene.com/",
"logo": "https://www.gene.com/assets/frontend/img/Genentech_logo.png",
"description": "Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases.",
"contactPoint": {
"@type": "ContactPoint",
"telephone": "+1-877-436-3683",
"contactType": "customer service"
},
"address": {
"@type": "PostalAddress",
"streetAddress": "1 DNA Way",
"addressLocality": "South San Francisco",
"addressRegion": "California",
"postalCode": "94080",
"addressCountry": "US"
}
}
/sclc.html
[
{
"@context": "http://schema.org",
"@type": "Organization",
"name": "Genentech",
"url": "https://www.gene.com/",
"logo": "https://www.gene.com/assets/frontend/img/Genentech_logo.png",
"description": "Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases.",
"contactPoint": {
"@type": "ContactPoint",
"telephone": "+1-877-436-3683",
"contactType": "customer service"
},
"address": {
"@type": "PostalAddress",
"streetAddress": "1 DNA Way",
"addressLocality": "South San Francisco",
"addressRegion": "California",
"postalCode": "94080",
"addressCountry": "US"
}
},
{
"@context": "https://schema.org",
"@type": "VideoObject",
"name": "Dear Danny Video for ES-SCLC | TECENTRIQ® (atezolizumab)",
"description": " Find information about TECENTRIQ® (atezolizumab) for extensive-stage small cell lung cancer (ES-SCLC). See full safety at the end of the video for more information.",
"thumbnailUrl": "https://cf-images.us-east-1.prod.boltdns.net/v1/static/6125588073001/9120be34-cad8-4fbe-a754-40287f1046bd/20d4730f-2d40-4541-be2d-06400cf2964e/1280x720/match/image.jpg",
"uploadDate": "2023-12-18T20:41:44.023Z",
"duration": "PT6M14.485S"
}
]
/melanoma.html
{
"@context": "http://schema.org",
"@type": "Organization",
"name": "Genentech",
"url": "https://www.gene.com/",
"logo": "https://www.gene.com/assets/frontend/img/Genentech_logo.png",
"description": "Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases.",
"contactPoint": {
"@type": "ContactPoint",
"telephone": "+1-877-436-3683",
"contactType": "customer service"
},
"address": {
"@type": "PostalAddress",
"streetAddress": "1 DNA Way",
"addressLocality": "South San Francisco",
"addressRegion": "California",
"postalCode": "94080",
"addressCountry": "US"
}
}
Your Diagnosis
Before revealing the machine’s verdict, predict the BS score for each signal. Higher = more BS (more fluff, less verifiable substance). Drag each slider, then submit to compare your judgment against the engine.
Stuck? Reveal the heuristic lens — how the deterministic page-auditor reads each signal (no AI, pure pattern rules)
These are the structural rules a local, deterministic auditor applies — the same lens you can use to judge each signal. They describe what to look for, not this company’s result.
Classify each sentence as substantive or hollow. Grounding markers — numbers, currencies, dates, technical units, named entities — outweigh marketing adjectives. When fluff sits right next to hard evidence, the fluff is forgiven.
Pull the main entities out of the H1, then check whether they actually recur through the body. A page that announces one thing and then talks about another drifts. Headings with no real sentences underneath read as pseudo-substance.
Count trust words (review, testimonial, rating, verified) against real outbound proof links (Google, Trustpilot, Clutch, G2, Yelp). Lots of trust language with zero verification links is trust theatre. Unlinked logo galleries count against it.
Look at how much sentence length varies. Natural writing varies its rhythm; templated or mass-produced copy is statistically uniform. Very low variation reads as commodity content — unless unique named entities break the pattern.
Inspect the JSON-LD. Is there an Organization or Person schema, and does it carry sameAs links to real external profiles (LinkedIn, socials)? Missing schema or no identity declaration signals an anonymous entity.
Want to apply this lens yourself? The free BS Indicator Chrome extension runs these heuristic checks live on any page. Bear in mind it is a single-page, deterministic tool — it relies only on pattern rules for the page in front of it and does not perform the cross-page semantic correlation this audit uses, so its readout is a starting lens, not the full verdict.
Based on 784 businesses audited.
Medical Devices, Pharma & Biotech BS: Genentech (TECENTRIQ) (tecentriq.com)
Regulated medical substance wrapped in a thick layer of emotional pharmaceutical clichés and lifestyle marketing. While the clinical specifications are high-substance, the presentation relies on trust theatre and heavy repetition of mandatory safety data. It is a textbook example of a site that is legally compliant but functionally bloated with marketing air.
Replace lifestyle H1s like Bedtime Rituals… with specific therapeutic outcomes or patient eligibility summaries to increase immediate information density. Add direct outbound links to ClinicalTrials.gov for the specific trials mentioned to resolve the proof_links_count deficit. Implement Person schema for the medical professionals who authored or reviewed the treatment guides. Include actual efficacy statistics, such as progression-free survival rates, directly in the sub-page hero sections to ground emotional claims in data.
The website is a perfect match for the Pharma & Biotech industry, specifically focusing on oncology immunotherapy. The content is heavily regulated and technical, matching the expected profiles for atezolizumab treatment guidelines.
“The BS score of 31 is primarily driven by the Trust and Proof pillar and Information Density. The trust_theatre_flag was triggered by the presence of unverified reviews and a lack of outbound proof links. Information density points were added for the 100% fluff H1s on sub-pages and the high level of concept repetition across the site.”
This training module utilizes a snapshot of public data from Genentech (TECENTRIQ), captured on June 19, 2026, to demonstrate how machine logic evaluates different types of business narratives.
Purpose: This data is presented under “Fair Use” / “Educational Exception” for the purpose of forensic semantic analysis, allowing users to compare human intuition against machine-generated evaluations.
Notice to Genentech (TECENTRIQ): This analysis is part of a non-adversarial audit conducted by 1 Euro SEO. The results provided by 1EuroSEO are intended as professional feedback to help improve any website’s machine-readability and authority signals. The 1EuroSEO BS Detection Tool is a free tool, and anyone can test any company to see how their content is interpreted by AI models.
Any company can use the insights for free and improve its voice by comparing it to industry clichés or competitors. When a company has updated its content, it can always submit a new audit request, which will be reflected in a new current score.
To all users: You are encouraged to visit the live site at https://tecentriq.com to view the most current version of its content and learn from the source what this company is about and what it offers.