Training Example: XELJANZ (Pfizer) – Review the Data, Give Your Score & Compare to the Real AI Evaluation

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[H1] Imagine Everyday Moments With Symptom Relief
You and your doctor can work together to find a medicine that may help improve your symptoms for certain conditions. XELJANZ is a pill approved to treat adults when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used and did not work well or cannot be tolerated. See conditions below:

Moderate to Severe Rheumatoid Arthritis
Moderate to Severe Ulcerative Colitis

Psoriatic Arthritis
Ankylosing Spondylitis

XELJANZ is approved to treat children ages 2 and older when TNF blockers did not work well or could not be tolerated. See conditions below:

Polyarticular Course Juvenile Idiopathic Arthritis

Juvenile Psoriatic Arthritis

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patients in focus
[H2] A Closer Look at Real Patient Stories
Learn more about real adult XELJANZ patients with moderate to severe rheumatoid arthritis (RA), active psoriatic arthritis (PsA), and moderate to severe ulcerative colitis (UC). They were prescribed XELJANZ after TNF blockers did not work well or could not be tolerated. As ambassadors, they share their treatment stories to remind you that you’re not alone. Individual results may vary. Patient ambassador stories have been developed in partnership with Pfizer.
Hear From Real Patients

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[H2] Meet Ashley
Real XELJANZ
RA Patient

[H2] Meet Stephanie
Real XELJANZ
UC Patient

[IMG: Stephanie real patient stories]

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[H2] 13+ Years in RA
XELJANZ has been prescribed for more than 13 years, since initial approval in 2012, for adults with moderate to severe rheumatoid arthritis.* XELJANZ was approved for use in adults with active psoriatic arthritis* in 2017, adults with moderate to severe ulcerative colitis* in 2018, and adults with active ankylosing spondylitis in 2021.
In 2020, XELJANZ was approved for use in patients ages 2 and older with active polyarticular course juvenile idiopathic arthritis.*
In 2025, XELJANZ was approved for expanded use in children ages 2 and older with active psoriatic arthritis.*
*Indication revised to use in patients who have not responded or cannot tolerate one or more TNF blockers.
https://main--xeljanzcomxeljanz--pfizer.hlx.page/global/fragments/first-approved Metadata

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Hand stretches—along with an RA treatment that works for you—may help your joints.* Watch the video and stretch your hands in style with this 80s rewind.
*Source: Strengthening and stretching with Rheumatoid Arthritis of the hand (SARAH) Study
Watch Now

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[H2] Getting Started With XELJANZ

[H3] I'm Ready To Talk To My Doctor
Explore Discussion Tools

[H3] I Need Help Affording My Prescription
View Savings & Support Options Terms and Conditions Apply

[H3] I Want Support Resources
Sign Up For XELJANZ+YOU

[H3] I’m Ready To Fill My Prescription
Get Started

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[H2] Discover Support Resources
The XELJANZ Support Program provides tools and information to help you take an active role in managing your RA with XELJANZ. Sign up to receive emails filled with helpful information and lifestyle suggestions.
Sign Up Now

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[H1] XELJANZ Support and Co-Pay Savings Programs
Whether you and your doctor are considering XELJANZ to treat your condition, or you’ve recently been prescribed XELJANZ, sign up below to receive information about XELJANZ, lifestyle tips, and tools for the different stages of your treatment journey. Plus, if you’ve already been prescribed XELJANZ, you can register below for the XELJANZ Co-Pay Savings Program or other financial support resources you may be eligible for.

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[H1] Small Moments Could Become Big Wins With RA Symptom Relief

[H3] XELJANZ can help relieve joint pain, swelling, and stiffness, and helps stop further joint damage.
XELJANZ is used to treat adults with moderately to severely active rheumatoid arthritis when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used and did not work well or cannot be tolerated.

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[H2] Results From RA Clinical Trials* Prove XELJANZ Can:

Help relieve joint pain, swelling, and stiffness

Help stop further joint damage

Help some people experience RA symptom reduction within2 weeks †

Help some people feelless RA fatigue

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For others it could take up to three months or longer. Individual results may vary.
Adult patients with moderate to severe RA were evaluated in clinical trials. Some patients in the clinical studies were taking background medicines such as methotrexate and some were not. Some studies evaluated patients when other medicines such as methotrexate or TNF blockers did not work well or could not be tolerated. XELJANZ is approved for use in patients when TNF blockers did not work well or could not be tolerated.
Explore Clinical Trial Results

[H2] Discover RA Support Resources
The XELJANZ Support Program provides tools and information to help you take an active role in managing your RA with XELJANZ. Sign up to receive emails filled with helpful information and lifestyle suggestions.
Sign Up Now

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patients in focus
[H2] A Closer Look at Real Patient Stories
Learn more about real adult XELJANZ patients with moderate to severe rheumatoid arthritis (RA), active psoriatic arthritis (PsA), or moderate to severe ulcerative colitis (UC). They were prescribed XELJANZ after TNF blockers did not work well or could not be tolerated. As ambassadors, they share their treatment stories to remind you that you’re not alone. Individual results may vary. Patient ambassador stories have been created in partnership with Pfizer.
Hear From Real Patients

[IMG: Ashley real patient stories]

[H2] Meet Ashley
Real XELJANZRA Patient

[IMG: real patient Ronda in kitchen smiling]

[H2] Meet Ronda
Real XELJANZRA Patient

[IMG: meet patient Alison smiling]

[H2] Meet Alison
Real XELJANZRA Patient

[IMG: patient Lisa outside walking]

[H2] Meet Lisa
Real XELJANZRA Patient

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Symptoms of Rheumatoid Arthritis
[H2] Take A Closer Look At How The Progression Of RA Can Cause Permanent Joint Damage
Want To Learn More About RA? Get Facts

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Symptoms of Rheumatoid Arthritis
[H2] The body attacks healthy joint tissue, causing the synovium to thicken and to expand.
Want To Learn More About RA? Get Facts

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Symptoms of Rheumatoid Arthritis
[H2] A pannus begins to form that can lead to the destruction of articular cartilage exposing the bone beneath it.
Want To Learn More About RA? Get Facts

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Symptoms of Rheumatoid Arthritis
[H2] If your RA is not treated or is undertreated, the effects of pannus may cause additional damage to the bone itself.
Want To Learn More About RA? Get Facts

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Symptoms of Rheumatoid Arthritis
[H2] In extreme instances, pannus may invade the joint further, resulting in fibrous ankylosis and possibly even bony ankylosis. Though rare because RA is not often left untreated, this condition may lead to decreased range of motion.
Want To Learn More About RA? Get Facts
Video

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These images of potential disease symptoms are for illustrative purposes only and are not intended to be fully anatomically accurate.

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[H2] Working With Your Doctor
If your current treatment isn't working well enough to manage your RA symptoms, it's important to have an open and honest discussion with your doctor. Every appointment is an opportunity to improve the dialogue with your doctor and discuss how to manage your RA. Ready to make an appointment? Find A Healthcare Provider near you.

[H3] Prepare
Before your next appointment, get ready for the conversation by reflecting on your current treatment plan and tracking your recent symptoms. The information could be helpful in finding a treatment plan that may work best for you.

[H3] Share
It may help make it easier to talk about if you write down any questions or concerns you may have ahead of your appointment to give your doctor a complete picture of your situation.

[H3] Align
Communicate with your healthcare team to help them understand your goals, concerns, and expectations. This conversation will be useful in getting everyone on the same page.

View Doctor Discussion Guide

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[IMG: XELJANZ (tofacitinib) 5mg prescription bottle]

[H2] Easy-To-Open Bottle
The easy-to-open XELJANZ bottle cap has received an Arthritis Foundation Ease-of-Use Commendation.‡
The Arthritis Foundation's Ease of Use Commendation recognizes products, such as the XELJANZ bottle cap, which are intended to make certain tasks easier for people who have arthritis and other physical limitations.
Learn more at arthritis.org.
‡This website is neither owned nor controlled by Pfizer. Pfizer does not endorse and is not responsible for the content or services of this site.

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[H1] Considering a Different Treatment For Your Child's Active Polyarticular Course Juvenile Idiopathic Arthritis (pcJIA) or Juvenile Psoriatic Arthritis (jPsA)?
Ask your child's doctor about XELJANZ —the first and only JAK inhibitor approved to treat active pcJIA or jPsA in children 2 and older when TNF blockers did not work well or could not be tolerated.

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[H2] How is XELJANZ available to be prescribed for children 2 and older with active pcJIA or jPsA?

XELJANZ oral solution (1 mg/mL)

Who Is It For?children 2 and olderweighing at least 22 lb.
How Is It Delivered?oral solution, grape-flavored
Always use the oral dosing syringe that comes with XELJANZ oral solution to measure and take your prescribed dose. Ask your healthcare provider or pharmacist to show you how to measure your prescribed dose if you are not sure.
When Is It Taken?2 times a day, with or without food

XELJANZ Tablet (5 mg)

Who Is It For?children 2 and olderweighing at least 88 lb.
How Is It Delivered?Pill
When Is It Taken?2 times a day, with or without food

If you take too much XELJANZ or XELJANZ oral solution, call your healthcare provider or go to the nearest hospital emergency room right away
XELJANZ XR should not be used instead of XELJANZ oral solution

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[H2] Questions About XELJANZ and XELJANZ oral solution

What is XELJANZ?
XELJANZ is a prescription medicine called a Janus kinase (JAK) inhibitor. XELJANZ (tofacitinib) is used to treat children 2 years of age and older with active polyarticular course juvenile idiopathic arthritis or juvenile psoriatic arthritis when 1 or more tumor necrosis factor (TNF) blocker medicines have been used, and did not work well or cannot be tolerated.

What is XELJANZ oral solution?
XELJANZ oral solution is used to treat children 2 years of age and older with active polyarticular course juvenile idiopathic arthritis or juvenile psoriatic arthritis when 1 or more tumor necrosis factor (TNF) blocker medicines have been used, and did not work well or cannot be tolerated. XELJANZ oral solution 1 mg/mL is a grape flavored, clear, colorless solution. Always use the oral dosing syringe that comes with XELJANZ oral solution to measure and take your prescribed dose. Ask your healthcare provider or pharmacist to show you how to measure your prescribed dose if you are not sure. Take XELJANZ oral solution 2 times a day with or without food.

What is the Most Important Information I should know about XELJANZ/​XELJANZ oral solution?
The safety information below applies to all marketed formulations of XELJANZ. Specific risks associated with certain dosing are noted.
Serious infections. XELJANZ can lower the ability of your immune system to fight infections. Do not start taking XELJANZ if you have any kind of infection unless your healthcare provider tells you it is okay. Serious infections have happened in people taking XELJANZ. These serious infections include tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Your healthcare provider should test you for TB before starting and during treatment with XELJANZ. You should not start taking XELJANZ if you have any kind of infection unless your healthcare professional tells you it is okay.
Before and after starting XELJANZ, tell your doctor if you are being treated for an infection, have infections that keep coming back, or have symptoms of an infection, including:
fever, sweating, or chills
cough
blood in phlegm
warm, red, or painful skin or sores on your body
burning when you urinate
urinating more often than normal
muscle aches
shortness of breath
weight loss
diarrhea or stomach pain
feeling very tired
Increased risk of death in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking XELJANZ 5 mg or 10 mg twice daily.
Cancer and immune system problems. XELJANZ may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers, including skin cancers, can happen. People taking XELJANZ 5 mg or 10 mg twice daily have a higher risk of certain cancers including lymphoma and lung cancer, especially if you are a current or past smoker. Tell your healthcare provider if you have ever had any type of cancer.
Higher dose. People with ulcerative colitis taking the higher dose of XELJANZ (10 mg twice daily) or XELJANZ XR (22 mg one time each day) have a higher risk of serious infections, shingles, or skin cancers.
Increased risk of major cardiovascular events such as heart attack, stroke or death in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking XELJANZ 5 mg or 10 mg twice daily, especially if you are a current or past smoker.
Get emergency help right away if you have any symptoms of a heart attack or stroke while taking XELJANZ, including:
discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
pain or discomfort in your arms, back, neck, jaw, or stomach
shortness of breath with or without chest discomfort
breaking out in a cold sweat
nausea or vomiting
feeling lightheaded
weakness in one part or on one side of your body
slurred speech
Blood clots in the lungs (pulmonary embolism, PE), veins of the legs (deep vein thrombosis, DVT), and arteries (arterial thrombosis) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking XELJANZ 5 mg or 10 mg twice daily. Blood clots in the lungs have also happened in people with ulcerative colitis. Some people have died from these blood clots.
Stop taking XELJANZ and tell your healthcare provider right away if you have any signs and symptoms of blood clots such as sudden shortness of breath, difficulty breathing, chest pain, swelling of a leg or arm, leg pain or tenderness, or red or discolored skin in the leg or arm.
Tears (perforation) in the stomach or intestines. Tell your healthcare provider if you have had diverticulitis (inflammation in parts of the large intestine) or ulcers in your stomach or intestines. Some people taking XELJANZ can get tears in their stomach or intestine. This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or methotrexate. Tell your healthcare provider right away if you have fever, stomach-area pain that does not go away, and a change in your bowel habits.
Serious allergic reactions can occur. Stop using XELJANZ and call your healthcare provider right away if you have swelling of your lips, tongue, throat, or get hives.
Changes in certain lab test results. Your doctor should do blood tests to check your white and red blood cells before starting and while you are taking XELJANZ. Your doctor should also check certain liver tests. You should not take XELJANZ if your lymphocyte count, neutrophil count, or red blood cell count is too low or your liver function test levels are too high. Changes in lab test results may cause your healthcare provider to stop your XELJANZ treatment for a time. Your cholesterol levels should be checked 4 to 8 weeks after you start receiving XELJANZ.
These are not all of the possible side effects of XELJANZ/XELJANZ oral solution. Learn more and read the Medication Guide.

How should I store XELJANZ oral solution?
Store XELJANZ oral solution at room temperature between 20°C to 25°C (68°F to 77°F). Always store XELJANZ in its original bottle and carton in order to protect from light. Keep XELJANZ and all medicines out of the reach of children.

What should I tell my child’s (2 or older) healthcare provider before starting with XELJANZ/XELJANZ oral solution?
Before you use XELJANZ, tell your healthcare provider if you:
Are being treated for an infection, have an infection that won’t go away or keeps coming back, or think you have symptoms of an infection
Have TB, or have been in close contact with someone with TB, or were born in, lived in, or traveled where there is more risk for getting TB
Have diabetes, chronic lung disease, HIV, or a weak immune system. People with these conditions have a higher chance for infections
Live or have lived in certain areas (such as Ohio and Mississippi River Valleys and the Southwest) where there is an increased chance for getting certain kinds of fungal infections
Have or have had Hepatitis B or C
Are a current or past smoker
Have had any type of cancer
Have had a heart attack, other heart problems or stroke
Have had blood clots
Have liver or kidney problems
Have any stomach area (abdominal) pain or been diagnosed with diverticulitis or ulcers in your stomach or intestines
Have recently received or plan to receive a vaccine. People taking XELJANZ should not receive live vaccines but can receive non-live vaccines
Are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed. You should not take XELJANZ and breastfeed
Have had a reaction to tofacitinib or any of the ingredients
Are taking other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take any of the following medicines while taking XELJANZ since this may increase your risk of infection:
tocilizumab (Actemra®)
etanercept (Enbrel®)
adalimumab (Humira®)
infliximab (Remicade®)
rituximab (Rituxan®)
abatacept (Orencia®)
anakinra (Kineret®)
certolizumab (Cimzia®)
golimumab (Simponi®)
ustekinumab (Stelara®)
secukinumab (Cosentyx®)
vedolizumab (Entyvio®)
ixekizumab (Taltz®)
sarilumab (Kevzara®)
azathioprine, cyclosporine, or other immunosuppressive drugs

Tell your healthcare provider if you are taking medicines that affect the way certain liver enzymes work. Ask your healthcare provider if you are not sure if your medicine is one of these.
These are not all of the possible side effects of XELJANZ/XELJANZ oral solution. Learn more and read the Medication Guide.

What are possible side effects of XELJANZ/XELJANZ oral solution?
See Most Important Information I should know about XELJANZ/XELJANZ oral solution
If you are a carrier of the Hepatitis B or C virus (viruses that affect the liver), the virus may become active while you use XELJANZ. Your healthcare provider may do blood tests before starting and while using treatment with XELJANZ. Tell your healthcare provider if you have any signs of these symptoms: feel very tired, little or no appetite, clay-colored bowel movements, chills, muscle aches, skin rash, skin or eyes look yellow, vomiting, fevers, stomach discomfort, or dark urine.
Common side effects in children (2 & older) with polyarticular course juvenile arthritis and psoriatic arthritis include upper respiratory tract infections (common cold, sinus infections), nasal congestion, sore throat, and runny nose (nasopharyngitis), headache, fever, nausea, vomiting, and acne.
These are not all of the possible side effects of XELJANZ/XELJANZ oral solution. Learn more and read the Medication Guide.

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[H2] Savings & Support
Is your child (age 2 or older) starting on treatment with XELJANZ for pcJIA or jPsA, but you’re concerned about covering the cost? You may be eligible for the XELJANZ Co-Pay Savings Program for commercially insured patients or qualify for other financial support resources to help your child access their treatment. Terms and conditions and eligibility requirements apply.

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[H2] Pay as little as $0 per month for your child's XELJANZ prescription †
†Eligibility required. May have annual savings up to $4,000-$15,000 depending on insurance.Federal and state healthcare beneficiaries ineligible. No membership fee. Offer not validfor cash paying patients. Terms and conditions apply.

[IMG: XELJANZ (tofacitinib) co-pay savings card]

If you are unable to confirm your eligibility or have additional questions, call XELSOURCE at 1-844-935-5269.
†For eligible underinsured or uninsured patients, XELSOURCE may offer financial assistance through the Pfizer Patient Assistance Program. Call XELSOURCE to learn more about these programs. Terms and conditions/eligibility requirements apply.

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[H2] For additional support, there’s XELSOURCE
You may need a little extra help getting started after your child has been prescribed XELJANZ.

Call XELSOURCE for help:
Contacting your insurance company on your behalf
Helping investigate and assess your eligibility for coverage when needed
Confirming your out-of-pocket costs
Assisting you with obtaining Prior Authorization (PA) when needed
Providing a patient portal at xelsourcepatientportal.com to allow you to monitor the status of your XELJANZ prescription once received by XELSOURCE

Ready to fill your XELJANZ prescription? See where you are in the process
To speak to someone at XELSOURCE about your insurance coverage and XELJANZ costs for your child, Monday through Friday, 8:00 AM-8:00 PM ET, call 1-844-935-5269 and say "Representative."

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MONDAY-FRIDAY, 8:00 AM–8:00 PM ET
Mon-Fri, 8am - 8pm ET
1-844-935-5269