Training Example: RADIESSE – Review the Data, Give Your Score & Compare to the Real AI Evaluation

[H1] With love from your future self
Imagine skin that’s resilient and authentically you—a gift to your future self. RADIESSE is the #1 researched biostimulator, proven to firm, tighten, and reverse visible signs of aging from within.
Find a Provider
WHAT IS RADIESSE?
[H2] With RADIESSE, every day is a love letter from your future self
RADIESSE works with your body, activating skin’s regenerative power to boost collagen, elastin, and other key proteins. It restores skin quality and function from the inside out—delivering firmer, more elastic skin that looks healthier and more resilient over time.
But don’t just take our word for it. Take a look at the difference RADIESSE has made for real people.
Actual patient. Individual results may vary.
Actual patient. Individual results may vary.
[H3] Jackie, 52
“I love how natural-looking my results are.”
Treatment Plan
Jackie, age 52, 4 weeks after being injected with 4.3 cc of RADIESSE (+) and 1.2 cc of RADIESSE in the lower face.
Before & After Results
RADIESSE benefits: FIRMS, TIGHTENS, REVERSES
[H2] Rebuild foundational elements of your skin
True skin strength starts deep beneath the surface. RADIESSE activates skin’s regenerative power, delivering measurable improvements in skin quality and reversing the visible signs of aging.
Discover RADIESSE
[IMG: Three diverse women with firm, radiant skin illustrating anti-aging skin treatment results.]
Actual patients. Individual results may vary.
[H3] What my future self will thank me for
[H4] REAL PATIENT RESULTS WITH RADIESSE
“RADIESSE helps support collagen and elastin production over time, so this felt like the perfect next step in my wellness journey!”
Kam WilliamsRADIESSE Patient

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Actual patient. Individual results may vary.
REGENERATIVE SKIN SCIENCE
[H2] How RADIESSE works
What is happening under the skin as we age? And why does a non-inflammatory pathway matter for biostimulation? Discover this and more as you dive into the science behind RADIESSE.
Regenerate With RADIESSE
[IMG: Woman outdoors smiling and touching her face]
Actual patient. Individual results may vary.
[IMG: Man with smooth, healthy-looking skin touching his face]
Actual patient. Individual results may vary.
[H3] Join the conversation @RADIESSE
Follow Us on Instagram
[H2] Common questions
[H3] What is RADIESSE?+
RADIESSE and RADIESSE (+) are dermal fillers that are FDA-approved to smooth moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth).1,2 RADIESSE is also used for correcting volume loss in the back of the hands.3
[H3] What can I expect during an appointment for RADIESSE?+
RADIESSE is injected under the skin in a quick procedure that can be done over the lunch hour.1
[H3] How soon will I see results with RADIESSE, and how long will they last?+
Restoration of volume and smoothing of the appearance of wrinkles and lines are visible immediately after a RADIESSE treatment.1,4 Over time, RADIESSE stimulates the production of collagen5-9 and elastin,6-8,10 supporting continued improvement in skin quality.7 Results have been shown to last up to 2 years.11
More Frequently Asked Questions
References:1. Radiesse [Instructions for Use]. Franksville, WI: Merz North America, Inc; 2023. ​2. Radiesse (+) [Instructions for Use]. Franksville, WI: Merz North America, Inc; 2023. ​3. Radiesse for Hands [Instructions for Use]. Franksville, WI: Merz North America, Inc; 2023. ​4. Tzikas TL. Dermatol Surg. 2008;34(suppl 1):S9-S15. ​5. Yutskovskaya Y, et al. J Drugs Dermatol. 2014;13(9):1047-1052. ​6. Yutskovskaya YA, et al. J Drugs Dermatol. 2017;16(1):68-74. ​7. Yutskovskaya YA, et al. J Drugs Dermatol. 2020;19(4):405-411. ​8. Nowag B, et al. CaHA microspheres: contact with fibroblasts and amount of spheres are key factors for collagen stimulation. Presented at: AMWC 2020; Monte Carlo, Monaco; April 2-4, 2020.​9. Aguilera SB, et al. Aesthet Surg J. 2023;43(10):1063-1090.​10. González N, et al. Dermatol Surg. 2019;45(4):547-551. ​11. Bass LS, et al. Aesthet Surg J. 2010;30(2):235-238.
Book a Consultation
[H2] Ready to re-awaken your skin from within?
Find a provider in your area and book a consultation to see if RADIESSE is right for you.
Find a Provider
[IMG: Diverse group of women smiling with healthy-looking skin.]
Actual patients. Individual results may vary.
View More
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[H2] What are RADIESSE® and RADIESSE® (+)?
RADIESSE® and RADIESSE® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth).
RADIESSE® is also used for correcting volume loss in the back of the hands and, when diluted with saline to smooth away wrinkles such as those in the décolleté in patients 22 years of age and older. RADIESSE® (+) is also used for improving moderate to severe loss of jawline contour in adults over 21 years old.
[H2] RADIESSE® and RADIESSE® (+) IMPORTANT SAFETY INFORMATION
[H3] Who should not use RADIESSE® or RADIESSE® (+)?
You should not use RADIESSE® or RADIESSE® (+) if you have an allergy to any component of the product, if you have a history of severe allergies, if you have a bleeding disorder. You should not use RADIESSE® (+) if you have an allergy to lidocaine or medicines like it.
[H3] What is the most important information I should know about RADIESSE® and RADIESSE® (+)?
One of the risks with using these products is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your health care practitioner immediately.
As with all procedures that involve an injection through the skin, there is a risk of infection.
Do not use RADIESSE® or RADIESSE® (+) if you have a skin infection until it has healed.
It is not known if RADIESSE® or RADIESSE® (+) is safe or effective in the lips, or in the area around the eyes, or if you are pregnant or breastfeeding.
It is not known if RADIESSE® or RADIESSE® (+) is safe or effective beyond 3 years in the face, 1 year in the hand, and 84 weeks in the décolleté.
Injection of RADIESSE® (+) into the jawline may temporarily alter jaw function.
The safety of RADIESSE® in the décolleté in patients under 22 years of age has not been established.
The microspheres in RADIESSE® and RADIESSE® (+) can be seen in X-rays and CT scans. It is very important that you tell your health care provider that you have had RADIESSE® or RADIESSE® (+) dermal filler. A clinical study found no evidence of RADIESSE® injected in the décolleté being visible on mammograms or breast ultrasounds, but you should still inform your doctor and radiologist that you have received RADIESSE® in the treated area so they can interpret your imaging appropriately.
If you have a history of herpes, you may experience a herpes breakout after receiving RADIESSE® or RADIESSE® (+).
Injection in the back of the hand may result in temporary difficulty performing activities. RADIESSE® may cause nodules, bumps or lumps in the back of the hand and can last up to 1 year.
You should minimize strenuous activity and avoid extensive sun or heat exposure for about 24 hours after treatment and until any swelling or redness has resolved.
[H3] What should I tell my doctor before using RADIESSE® or RADIESSE® (+)?
Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site. Tell your health care provider if you have any diseases, injuries or disabilities of the hand, if you have a history forming large, raised scars or if you have had any other skin treatments such as skin peels.
[H3] What are the most common adverse events with RADIESSE® or RADIESSE® (+)?
The most common adverse events seen in clinical studies of RADIESSE® used in the hands include bruising, redness, swelling, pain, itching, nodules or bumps/lumps, difficulty performing activities, loss of sensation and other local side effects. The most common adverse events seen in clinical studies of RADIESSE® or RADIESSE® (+) used in the face include bruising, redness, swelling, pain, itching, difficulty chewing, and other local side effects.
Delayed-onset inflammation near the site of injection is one of the known adverse events associated with dermal fillers. Cases of delayed-onset inflammation have been reported to occur at the treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own.
These are not all of the possible side effects with RADIESSE® or RADIESSE® (+). Merz collects information about adverse events seen with RADIESSE® and RADIESSE® (+) outside of clinical studies. These events are included in the RADIESSE® and RADIESSE® (+) Patient Information Guide based on an assessment of seriousness and potential causal relationship to RADIESSE® or RADIESSE® (+). Please see the Patient Information Guide available at www.radiesse.com for list of these events. Tell your health care provider about any side effects that bother you or do not go away.
Important: For full safety information, please visit www.Radiesse.com or call MyMerz Solutions at 1-844-469-6379
RADIESSE® and RADIESSE® (+) are available by prescription only.

[H1] Find a Provider by Location
[H2] Don’t have a RADIESSE provider yet?
No problem—finding one is simple. Use our locator tool to connect with an injector near you and discover how RADIESSE can help you achieve natural, lasting renewal that is uniquely yours.

[H2] Already have a provider you love?Ask for RADIESSE.
Your go-to aesthetic expert already knows what makes your features unique—now give them the power of regeneration. Simply ask your provider if RADIESSE is right for you and start your journey to stronger, more radiant skin.
[IMG: Dr. David Funt - Plastic Surgeon, United States.]
[H3] How to start the conversation
Let your provider know you’re interested in RADIESSE to improve volume loss or enhance contour. They can assess your goals, explain how RADIESSE works to stimulate collagen, and design a personalized treatment plan that helps your results evolve naturally over time.
Dr. David Funt is a paid consultant for Merz Aesthetics. His statements are based on his professional expertise.
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[H2] What are RADIESSE® and RADIESSE® (+)?
RADIESSE® and RADIESSE® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth).
RADIESSE® is also used for correcting volume loss in the back of the hands and, when diluted with saline to smooth away wrinkles such as those in the décolleté in patients 22 years of age and older. RADIESSE® (+) is also used for improving moderate to severe loss of jawline contour in adults over 21 years old.
[H2] RADIESSE® and RADIESSE® (+) IMPORTANT SAFETY INFORMATION
[H3] Who should not use RADIESSE® or RADIESSE® (+)?
You should not use RADIESSE® or RADIESSE® (+) if you have an allergy to any component of the product, if you have a history of severe allergies, if you have a bleeding disorder. You should not use RADIESSE® (+) if you have an allergy to lidocaine or medicines like it.
[H3] What is the most important information I should know about RADIESSE® and RADIESSE® (+)?
One of the risks with using these products is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your health care practitioner immediately.
As with all procedures that involve an injection through the skin, there is a risk of infection.
Do not use RADIESSE® or RADIESSE® (+) if you have a skin infection until it has healed.
It is not known if RADIESSE® or RADIESSE® (+) is safe or effective in the lips, or in the area around the eyes, or if you are pregnant or breastfeeding.
It is not known if RADIESSE® or RADIESSE® (+) is safe or effective beyond 3 years in the face, 1 year in the hand, and 84 weeks in the décolleté.
Injection of RADIESSE® (+) into the jawline may temporarily alter jaw function.
The safety of RADIESSE® in the décolleté in patients under 22 years of age has not been established.
The microspheres in RADIESSE® and RADIESSE® (+) can be seen in X-rays and CT scans. It is very important that you tell your health care provider that you have had RADIESSE® or RADIESSE® (+) dermal filler. A clinical study found no evidence of RADIESSE® injected in the décolleté being visible on mammograms or breast ultrasounds, but you should still inform your doctor and radiologist that you have received RADIESSE® in the treated area so they can interpret your imaging appropriately.
If you have a history of herpes, you may experience a herpes breakout after receiving RADIESSE® or RADIESSE® (+).
Injection in the back of the hand may result in temporary difficulty performing activities. RADIESSE® may cause nodules, bumps or lumps in the back of the hand and can last up to 1 year.
You should minimize strenuous activity and avoid extensive sun or heat exposure for about 24 hours after treatment and until any swelling or redness has resolved.
[H3] What should I tell my doctor before using RADIESSE® or RADIESSE® (+)?
Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site. Tell your health care provider if you have any diseases, injuries or disabilities of the hand, if you have a history forming large, raised scars or if you have had any other skin treatments such as skin peels.
[H3] What are the most common adverse events with RADIESSE® or RADIESSE® (+)?
The most common adverse events seen in clinical studies of RADIESSE® used in the hands include bruising, redness, swelling, pain, itching, nodules or bumps/lumps, difficulty performing activities, loss of sensation and other local side effects. The most common adverse events seen in clinical studies of RADIESSE® or RADIESSE® (+) used in the face include bruising, redness, swelling, pain, itching, difficulty chewing, and other local side effects.
Delayed-onset inflammation near the site of injection is one of the known adverse events associated with dermal fillers. Cases of delayed-onset inflammation have been reported to occur at the treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own.
These are not all of the possible side effects with RADIESSE® or RADIESSE® (+). Merz collects information about adverse events seen with RADIESSE® and RADIESSE® (+) outside of clinical studies. These events are included in the RADIESSE® and RADIESSE® (+) Patient Information Guide based on an assessment of seriousness and potential causal relationship to RADIESSE® or RADIESSE® (+). Please see the Patient Information Guide available at www.radiesse.com for list of these events. Tell your health care provider about any side effects that bother you or do not go away.
Important: For full safety information, please visit www.Radiesse.com or call MyMerz Solutions at 1-844-469-6379
RADIESSE® and RADIESSE® (+) are available by prescription only.

DISCOVER RADIESSE
[H1] Re-Awaken Skin From Within
Your skin possesses an incredible, innate power to renew itself. Discover how RADIESSE can activate your skin’s own natural process to target visible signs of aging in the face and beyond.
[H2] Discover where regeneration can take you
RADIESSE uses an ingredient that is also naturally found in your body to regenerate collagen, elastin, and other key proteins by activating skin’s natural pathway for self-renewal.
Explore how RADIESSE renews skin quality and restores natural contour in the areas where you may notice signs of aging—the lower face, hands, and jawline.
Download Patient Guide
Download Instructions for Use
Actual patient. Individual results may vary.
Actual patient. Individual results may vary.
Treatment Plan
Debra, age 62, after being injected with 2.9 cc of RADIESSE (+) in the midface to treat the lower face and 2.8 cc of RADIESSE in different wrinkles in the lower face.
Marionette Lines
These lines run downward from the corners of the mouth to the chin. RADIESSE can provide structural support to lift the corners and correct the downturned appearance.
Smile Lines
These are the creases (nasolabial folds) that run from the nose to the corners of the mouth. RADIESSE can restore volume and correct the deepening of these folds that occurs with aging.
Pre-Jowl Folds
These are the subtle hollows that appear on either side of the chin; RADIESSE restores volume to create a smoother, more defined jawline contour.
Corners of the Mouth
Volume loss here can cause the mouth to look downturned. RADIESSE supports the oral commissures for a more lifted expression.
Chin Wrinkles
These are the horizontal lines that crease the chin. RADIESSE adds foundational support to smooth creases and restore a refined contour to the lower face.
Actual patient. Individual results may vary.
Actual patient. Individual results may vary.
Treatment Plan
Andrea, age 42, 2 weeks after being injected with 3 mL of RADIESSE to treat the hands.
RADIESSE Can Enhance the Appearance of Hands by:
Restoring volume loss, which contributes to the signs of aging
Minimizing the visibility of veins and tendons
Actual patient. Individual results may vary.
Actual patient. Individual results may vary.
Treatment Plan
Jean, age 57, 4 weeks after being injected with 3.5 cc of RADIESSE (+) in the lower face to treat the jawline.
RADIESSE (+) Can Improve Jawline Contour:
For adults over the age of 21
Effective improvement in moderate to severe loss of jawline contour
[H2] Proven results across 3 key benefits
RADIESSE is a proven regenerative biostimulator that firms and tightens skin, reversing visible signs of aging from within. Learn more about how RADIESSE delivers these skin benefits along with measurable results from clinical trials that demonstrate its effectiveness.
Firms
[H3] RADIESSE improves skin firmness, elasticity, and hydration
RADIESSE utilizes an ingredient that is also naturally found in your body to activate your skin’s regenerative power—boosting collagen, elastin, and other key proteins.
[H4] Need firm numbers? The results are in.
23x
More collagen versus placebo*
96%
More elastin than baseline*
48%
Improved skin thickness versus baseline†
*Based on 6-month human tissue study versus placebo.†Compared to baseline in an 18-month study of 100 patients with human immunodeficiency virus (HIV) facial lipoatrophy.
[IMG: Woman pinching her skin showing firm skin]
Not an actual patient.
[IMG: Woman touching her skin showing tight skin]
Not an actual patient.
Tightens
[H3] RADIESSE regenerates key proteins to deliver smoother, tighter skin
RADIESSE enhances skin vitality by working with your body to strengthen skin structure and improve skin health.
[H4] The proof is in the profile.
94%
of patients showed improved smile lines from baseline‡
78%
of patients showed tighter skin§
‡Study design: In a randomized, split-face study (n=117), 94% of calcium hydroxylapatite–treated folds were rated as improved at 6 months (Global Aesthetic Improvement Scale).§Compared to baseline in 20 female subjects with self-evaluated flaccidity scores ≥3 on a 6-point scale (0, no flaccidity; 5, very severe flaccidity) in zones of interest.
Have questions about how to get results like these? Find answers to this and more.
Frequently Asked Questions
Reverses
[H3] RADIESSE reverses visible signs of aging
RADIESSE is the #1 researched biostimulator in Regenerative Aesthetics publications and is proven to reverse the visible signs of aging.
For younger, healthier-looking skin, so that you can look your best at any age.II
[H4] Results that go the extra mile
98%
patient satisfaction¶
2 yrs
improvements can last up to 2 years#
See the results that RADIESSE patients found so satisfying.
Before & After Results
‖RADIESSE is not indicated for individuals under the age of 18. Consult your physician to find out if RADIESSE is right for you. Please check your local regulatory approval.¶Study design: In a multicenter, randomized study (n=120), 98% of calcium hydroxylapatite–treated patients self-reported overall satisfaction at 4 months after the second injection.#Study design: Based on study that followed 102 patients for over 3 years to test the long-term effects of RADIESSE on smile lines.
[IMG: Woman looking forward touching her face with healthy-looking skin]
Not an actual patient.
[H2] Why choose RADIESSE for your skin during your GLP-1 journey?
RADIESSE can help address facial volume loss associated with rapid weight loss.
Lose Weight, Not Volume
GLP-1=glucagon-like peptide-1.
THE SCIENCE OF Healthier-Looking Skin
[H2] Ready to discover the science behind RADIESSE?
Take the next step and dive deeper into the science—simplified.
Regenerate With RADIESSE
[IMG: Diverse group of people with healthy-looking skin.]
Actual patients. Individual results may vary.
View More
View Less

[H2] What are RADIESSE® and RADIESSE® (+)?
RADIESSE® and RADIESSE® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth).
RADIESSE® is also used for correcting volume loss in the back of the hands and, when diluted with saline to smooth away wrinkles such as those in the décolleté in patients 22 years of age and older. RADIESSE® (+) is also used for improving moderate to severe loss of jawline contour in adults over 21 years old.
[H2] RADIESSE® and RADIESSE® (+) IMPORTANT SAFETY INFORMATION
[H3] Who should not use RADIESSE® or RADIESSE® (+)?
You should not use RADIESSE® or RADIESSE® (+) if you have an allergy to any component of the product, if you have a history of severe allergies, if you have a bleeding disorder. You should not use RADIESSE® (+) if you have an allergy to lidocaine or medicines like it.
[H3] What is the most important information I should know about RADIESSE® and RADIESSE® (+)?
One of the risks with using these products is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your health care practitioner immediately.
As with all procedures that involve an injection through the skin, there is a risk of infection.
Do not use RADIESSE® or RADIESSE® (+) if you have a skin infection until it has healed.
It is not known if RADIESSE® or RADIESSE® (+) is safe or effective in the lips, or in the area around the eyes, or if you are pregnant or breastfeeding.
It is not known if RADIESSE® or RADIESSE® (+) is safe or effective beyond 3 years in the face, 1 year in the hand, and 84 weeks in the décolleté.
Injection of RADIESSE® (+) into the jawline may temporarily alter jaw function.
The safety of RADIESSE® in the décolleté in patients under 22 years of age has not been established.
The microspheres in RADIESSE® and RADIESSE® (+) can be seen in X-rays and CT scans. It is very important that you tell your health care provider that you have had RADIESSE® or RADIESSE® (+) dermal filler. A clinical study found no evidence of RADIESSE® injected in the décolleté being visible on mammograms or breast ultrasounds, but you should still inform your doctor and radiologist that you have received RADIESSE® in the treated area so they can interpret your imaging appropriately.
If you have a history of herpes, you may experience a herpes breakout after receiving RADIESSE® or RADIESSE® (+).
Injection in the back of the hand may result in temporary difficulty performing activities. RADIESSE® may cause nodules, bumps or lumps in the back of the hand and can last up to 1 year.
You should minimize strenuous activity and avoid extensive sun or heat exposure for about 24 hours after treatment and until any swelling or redness has resolved.
[H3] What should I tell my doctor before using RADIESSE® or RADIESSE® (+)?
Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site. Tell your health care provider if you have any diseases, injuries or disabilities of the hand, if you have a history forming large, raised scars or if you have had any other skin treatments such as skin peels.
[H3] What are the most common adverse events with RADIESSE® or RADIESSE® (+)?
The most common adverse events seen in clinical studies of RADIESSE® used in the hands include bruising, redness, swelling, pain, itching, nodules or bumps/lumps, difficulty performing activities, loss of sensation and other local side effects. The most common adverse events seen in clinical studies of RADIESSE® or RADIESSE® (+) used in the face include bruising, redness, swelling, pain, itching, difficulty chewing, and other local side effects.
Delayed-onset inflammation near the site of injection is one of the known adverse events associated with dermal fillers. Cases of delayed-onset inflammation have been reported to occur at the treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own.
These are not all of the possible side effects with RADIESSE® or RADIESSE® (+). Merz collects information about adverse events seen with RADIESSE® and RADIESSE® (+) outside of clinical studies. These events are included in the RADIESSE® and RADIESSE® (+) Patient Information Guide based on an assessment of seriousness and potential causal relationship to RADIESSE® or RADIESSE® (+). Please see the Patient Information Guide available at www.radiesse.com for list of these events. Tell your health care provider about any side effects that bother you or do not go away.
Important: For full safety information, please visit www.Radiesse.com or call MyMerz Solutions at 1-844-469-6379
RADIESSE® and RADIESSE® (+) are available by prescription only.

REGENERATE WITH RADIESSE
[H1] The Science of Healthier-Looking Skin
Discover how RADIESSE uses an ingredient that is also naturally found in your body to activate your skin’s regenerative power—boosting collagen, elastin, and other key proteins.
Science You Can Feel
[H2] The regenerative science of RADIESSE–explained simply
[H3] +Video Transcript
RADIESSE is a regenerative biostimulator that boosts collagen, elastin, and key proteins in your skin. Our high-quality microspheres deliver firmer, tighter skin, proven to reverse visible signs of aging.
RADIESSE has been shown to boost collagen production up to 23x and increase elastin by 96%.1*
For a future that is smoother and more radiant, RADIESSE. Re-Awaken skin from within.
Talk to your healthcare professional to see if RADIESSE is right for you.
*Based on 6-month human tissue study versus placebo.
Reference: 1. Data on file. Merz North America, Inc. 2025.
[H2] Understanding skin aging
As early as age 25, collagen production declines by approximately 1.0% to 1.5% every year.1 Furthermore, elastin fibers become increasingly fragmented after age 40.2 The loss of key structural proteins like collagen and elastin can lead to thinner, more fragile skin.2
Beyond changes to skin’s quality, the entire facial structure changes as well. Beginning in your late 30s and 40s, facial fat shifts and shrinks, and even the underlying bone density decreases, leading to sinking, sagging, and deeper wrinkles.3
References:1. Reilly DM, et al. Plast Aesthet Res. 2021;8:2.2. Jiang F, et al. Sci Rep. 2025;15:28598.3. Swift A, et al. Aesthet Surg J. 2021;41(10):1107-1119.
[IMG: Comparison pictures showing the differences between 25 years and 65 years.]
Not an actual patient.
[IMG: Man with salt and pepper hair and beard.]
Actual patient. Individual results may vary.
[H2] RADIESSE is key
RADIESSE’s regenerative power lies in its ability to activate skin’s natural pathway to self-renewal. When RADIESSE is injected, it provides a “scaffold” that helps enable collagen and elastin to regenerate.
[H3] Skin renewal across 5 distinct measures of skin health
RADIESSE doesn’t just treat one issue—it makes skin healthier by targeting several important building blocks of skin health that gradually take effect and reinforce each other over time.
SUPPORT
Collagen Type I
Replenishing this type of collagen provides the skin with strength and resilience.1-5
STRUCTURE
Collagen Type III
This type of collagen creates an organized structure within your skin. This organized scaffolding is what differentiates the regenerative process of RADIESSE from undifferentiated collagen stimulation, such as scar tissue formation.1-5
ELASTICITY
Elastin
Regenerating this component inside the skin restores youthful “bounce” and recoil to combat age-related sagging.2-6
GLOW
Proteoglycans
These proteins help skin hold onto moisture, supporting a plump, hydrated glow.3,6
NOURISH
Angiogenesis
This is the process through which RADIESSE generates new blood flow to nourish skin tissue, supporting a pathway for oxygen and nutrients to maintain skin health.1,4,5
References:1. Yutskovskaya YA, et al. J Drugs Dermatol. 2017;16(1):68-74.2. Yutskovskaya Y, et al. J Drugs Dermatol. 2014;13(9):1047-1052.3. Nowag B, et al. CaHA microspheres: contact with fibroblasts and amount of spheres are key factors for collagen stimulation. Presented at: AMWC 2020; Monte Carlo, Monaco; April 2-4, 2020.4. Yutskovskaya YA, et al. J Drugs Dermatol. 2020;19(4):405-411.5. Aguilera SB, et al. Aesthet Surg J. 2023;43(10):1063-1090.6. González N, et al. Dermatol Surg. 2019;45(4):547-551.
[H2] Biostimulation replenishes the skin
Actual patient. Individual results may vary.
Actual patient. Individual results may vary.
It’s easy to think all injectable treatments are the same, but RADIESSE is what’s known as a biostimulator because it stimulates the skin’s regeneration process. Biostimulators target the body’s natural support structure to replenish its important building blocks.
Unlike some biostimulators that rely on the body’s immune system to work, RADIESSE works via a non-inflammatory pathway using an ingredient that also naturally occurs in your body.
This allows RADIESSE to produce results that continue to gradually develop over time, providing results that can last up to 2 years.
But this isn’t just theoretical—see how the science translates to real patient results in the Before & Afters gallery.
See Before & Afters
For RApID Weight-Loss Patients
[H2] On your rapid weight loss journey?
Rapid weight loss can affect more than just the body. Learn more about using RADIESSE to help address facial volume loss associated with rapid weight loss.
For Rapid Weight Loss
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Actual patients. Individual results may vary.
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[H2] What are RADIESSE® and RADIESSE® (+)?
RADIESSE® and RADIESSE® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth).
RADIESSE® is also used for correcting volume loss in the back of the hands and, when diluted with saline to smooth away wrinkles such as those in the décolleté in patients 22 years of age and older. RADIESSE® (+) is also used for improving moderate to severe loss of jawline contour in adults over 21 years old.
[H2] RADIESSE® and RADIESSE® (+) IMPORTANT SAFETY INFORMATION
[H3] Who should not use RADIESSE® or RADIESSE® (+)?
You should not use RADIESSE® or RADIESSE® (+) if you have an allergy to any component of the product, if you have a history of severe allergies, if you have a bleeding disorder. You should not use RADIESSE® (+) if you have an allergy to lidocaine or medicines like it.
[H3] What is the most important information I should know about RADIESSE® and RADIESSE® (+)?
One of the risks with using these products is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your health care practitioner immediately.
As with all procedures that involve an injection through the skin, there is a risk of infection.
Do not use RADIESSE® or RADIESSE® (+) if you have a skin infection until it has healed.
It is not known if RADIESSE® or RADIESSE® (+) is safe or effective in the lips, or in the area around the eyes, or if you are pregnant or breastfeeding.
It is not known if RADIESSE® or RADIESSE® (+) is safe or effective beyond 3 years in the face, 1 year in the hand, and 84 weeks in the décolleté.
Injection of RADIESSE® (+) into the jawline may temporarily alter jaw function.
The safety of RADIESSE® in the décolleté in patients under 22 years of age has not been established.
The microspheres in RADIESSE® and RADIESSE® (+) can be seen in X-rays and CT scans. It is very important that you tell your health care provider that you have had RADIESSE® or RADIESSE® (+) dermal filler. A clinical study found no evidence of RADIESSE® injected in the décolleté being visible on mammograms or breast ultrasounds, but you should still inform your doctor and radiologist that you have received RADIESSE® in the treated area so they can interpret your imaging appropriately.
If you have a history of herpes, you may experience a herpes breakout after receiving RADIESSE® or RADIESSE® (+).
Injection in the back of the hand may result in temporary difficulty performing activities. RADIESSE® may cause nodules, bumps or lumps in the back of the hand and can last up to 1 year.
You should minimize strenuous activity and avoid extensive sun or heat exposure for about 24 hours after treatment and until any swelling or redness has resolved.
[H3] What should I tell my doctor before using RADIESSE® or RADIESSE® (+)?
Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site. Tell your health care provider if you have any diseases, injuries or disabilities of the hand, if you have a history forming large, raised scars or if you have had any other skin treatments such as skin peels.
[H3] What are the most common adverse events with RADIESSE® or RADIESSE® (+)?
The most common adverse events seen in clinical studies of RADIESSE® used in the hands include bruising, redness, swelling, pain, itching, nodules or bumps/lumps, difficulty performing activities, loss of sensation and other local side effects. The most common adverse events seen in clinical studies of RADIESSE® or RADIESSE® (+) used in the face include bruising, redness, swelling, pain, itching, difficulty chewing, and other local side effects.
Delayed-onset inflammation near the site of injection is one of the known adverse events associated with dermal fillers. Cases of delayed-onset inflammation have been reported to occur at the treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own.
These are not all of the possible side effects with RADIESSE® or RADIESSE® (+). Merz collects information about adverse events seen with RADIESSE® and RADIESSE® (+) outside of clinical studies. These events are included in the RADIESSE® and RADIESSE® (+) Patient Information Guide based on an assessment of seriousness and potential causal relationship to RADIESSE® or RADIESSE® (+). Please see the Patient Information Guide available at www.radiesse.com for list of these events. Tell your health care provider about any side effects that bother you or do not go away.
Important: For full safety information, please visit www.Radiesse.com or call MyMerz Solutions at 1-844-469-6379
RADIESSE® and RADIESSE® (+) are available by prescription only.