Training Example: Repatha (Amgen) – Review the Data, Give Your Score & Compare to the Real AI Evaluation

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[H3]

[H1] Important Safety Information
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.
Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Repatha® is available as prefilled single-dose SureClick® autoinjectors and prefilled single-dose syringes that either contain dry natural rubber (a derivative of latex) in the needle cover or are not made with natural rubber latex. The carton and “Instructions for Use" in the carton will state if your prefilled single-dose SureClick® autoinjector or prefilled single-dose syringe contains dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.
Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.
What are the possible side effects of Repatha®?
Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.
The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or bruising at the injection site.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
[H3] APPROVED USE
What is Repatha®?
Repatha® is an injectable prescription medicine used:
to reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina) requiring hospitalization, or certain types of heart surgery, in adults at increased risk for these events.
Along with diet and exercise to reduce low-density lipoprotein (LDL) or bad cholesterol in adults with high blood cholesterol levels called hypercholesterolemia and in adults with a type of high cholesterol called heterozygous familial hypercholesterolemia (HeFH).
Please see full Prescribing Information, including Patient Product Information.

Open

[H5]

IMPORTANT SAFETY INFORMATION
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.
Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex,
if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan

What Is Repatha®?Repatha® is a breakthrough medicine that can help you dramaticallylower bad (LDL) cholesterol and
reduce your risk of heart attack.
[H4] Why Repatha®?

[H3] BECAUSE YOU’RE HUMAN

[IMG: Robot]

This is Sam. He does not have high bad cholesterol. He also performs tasks perfectly.
When trying to lower your cholesterol, you’re expected to be perfect—like Sam. And if you don’t swap a steak for a salad or you feel like watching your favorite TV show instead of exercising, you may feel judgment from the people who matter most to you.
But unlike Sam, you’re human. And although you do your best to exercise and maintain a healthy diet, you also want to experience the joy of what makes you human.

With help from Repatha®, you can lower your bad cholesterol while you enjoy life. Because You’re Human.

Every heart has its own story. Whether you’ve already had a heart attack or stroke or are working to reduce the risk of having one, Repatha® can help protect your heart from a major cardiovascular event, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina) requiring hospitalization, or certain types of heart surgery.

Help lower your LDL-C and your risk of
another heart attack or stroke with Repatha®

Help lower your LDL-C and risk of a
first heart attack with Repatha®

In a study of adults with cardiovascular disease taking statins, Repatha® was shown to help by:

Repatha® starts working quickly. In just 2 weeks, it starts working to bring LDL-C down, with a
[H2] 63%

average reduction in just 3 months.

[H2] 84%

of patients lowered high LDL-C to below 55 mg/dL in 1 month.
Everyone's recommended LDL-C level may be different. Talk to your doctor about what is right for you.

Proven to cut risk of a heart attack by
[H2] 27%

Patients not treated with Repatha® had more heart attacks (4.6%) compared to those treated with Repatha® (3.4%).

Proven to cut risk of a stroke by
[H2] 21%

Patients not treated with Repatha® had more strokes (1.9%) compared to those treated with Repatha® (1.5%).

Talk to your doctor about reducing your risk of a major cardiovascular event.

DOWNLOAD DOCTOR DISCUSSION GUIDE

In a study of adults at increased cardiovascular risk, who did not have a history of heart attack or stroke, and who may have already been on an additional LDL-C lowering treatment,* Repatha® was shown to help by:
*Any dose of statin with or without ezetimibe.

Repatha® lowered LDL-C by
[H2] 55%

[IMG: Diagram showing LDL-C level reduction after treatment]

Results from a subset of the study measured how much LDL-C was lowered over 48 weeks.

Repatha® cut risk of a first heart attack by

[H2] 36%

Patients not treated with Repatha® had more heart attacks (4.1%) compared to those treated with Repatha® (2.7%).

Talk to your doctor about reducing your risk of a major cardiovascular event.

DOWNLOAD DOCTOR DISCUSSION GUIDE

[H2] 10 Years of Impact.
Over 5 Million Patients Served Worldwide.*
Still Committed to Lowering LDL-C.

*Cumulative post-market exposure estimates from July 2015 through July 2025, on patients that have received at least 1 dose (estimates assume administration) of the product, which was estimated using prescription claims data (IQVIA) for the U.S. and units distributed (Amgen Finance Electronic Data Warehouse) with average drug utilization patterns (MarketScan claims data) for all other regions. Utilization assumptions were applied to calculate the unique number of patients.

[IMG: Headshot of Repatha® (evolocumab) Patient, Cathy]

“

With Repatha®, my LDL-C had dropped from over 100, down to 40.”
– CATHY, a real Repatha® patient who had a heart attack

HEAR MORE SUCCESS STORIES

Individual results may vary.

Repatha® Works Differently From a Statin
Take a look at this video that explains bad cholesterol and how to get yours down with Repatha®.

You've listened to your heart—now give it a voice.
[IMG: discussion-guide-v2]
It's important to talk to your doctor about your LDL-C. Not sure what to say? Our Doctor Discussion Guide can help you set goals and feel more supported as you head into that conversation.
You can download this guide, and consider bringing it to your next appointment.
[IMG: Illustration of cartoon heart pointing to the left]
DOWNLOAD GUIDE

I'VE HAD A HEART ATTACK

Jerry and his heart don't always agree.
So when it came to Repatha®, they talked it out.
Here's what happened.

Repatha® is also for people with an inherited condition that causes high bad cholesterol (called familial hypercholesterolemia, or FH), who still need to lower their bad cholesterol even though they diet and exercise.

For some people, poor diet, overweight/obesity, or low level of physical activity might not be the primary cause of high LDL-C. Sometimes high LDL-C is caused by an inherited condition called FH.

Heterozygous FH (HeFH) represents one form of this common genetic disorder that affects the liver’s ability to remove excess LDL-C. HeFH is an inherited condition, which means it is
caused by an abnormal gene that can be passed down from one of the parents. This can lead to premature cardiovascular disease, as well as other complications caused by high LDL-C.

Repatha® + a statin lowered LDL-C around an average of 60%.†
Repatha® drives LDL-C down in people with HeFH.

†Results from a study at week 12 compared to a placebo. Some patients were also on other cholesterol-lowering therapies. Repatha® was taken every 2 weeks or once monthly. Your results may vary.

Close

[H3]

[H1] Important Safety Information
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.
Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Repatha® is available as prefilled single-dose SureClick® autoinjectors and prefilled single-dose syringes that either contain dry natural rubber (a derivative of latex) in the needle cover or are not made with natural rubber latex. The carton and “Instructions for Use" in the carton will state if your prefilled single-dose SureClick® autoinjector or prefilled single-dose syringe contains dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.
Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.
What are the possible side effects of Repatha®?
Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.
The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or bruising at the injection site.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
[H3] APPROVED USE
What is Repatha®?
Repatha® is an injectable prescription medicine used:
to reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina) requiring hospitalization, or certain types of heart surgery, in adults at increased risk for these events.
Along with diet and exercise to reduce low-density lipoprotein (LDL) or bad cholesterol in adults with high blood cholesterol levels called hypercholesterolemia and in adults with a type of high cholesterol called heterozygous familial hypercholesterolemia (HeFH).
Please see full Prescribing Information, including Patient Product Information.

Open

[H5]

IMPORTANT SAFETY INFORMATION
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.
Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex,
if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan

Close

[H3]

[H1] Important Safety Information
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.
Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Repatha® is available as prefilled single-dose SureClick® autoinjectors and prefilled single-dose syringes that either contain dry natural rubber (a derivative of latex) in the needle cover or are not made with natural rubber latex. The carton and “Instructions for Use" in the carton will state if your prefilled single-dose SureClick® autoinjector or prefilled single-dose syringe contains dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.
Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.
What are the possible side effects of Repatha®?
Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.
The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or bruising at the injection site.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
[H3] APPROVED USE
What is Repatha®?
Repatha® is an injectable prescription medicine used:
to reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina) requiring hospitalization, or certain types of heart surgery, in adults at increased risk for these events.
Along with diet and exercise to reduce low-density lipoprotein (LDL) or bad cholesterol in adults with high blood cholesterol levels called hypercholesterolemia and in adults with a type of high cholesterol called heterozygous familial hypercholesterolemia (HeFH).
Please see full Prescribing Information, including Patient Product Information.

Open

[H5]

IMPORTANT SAFETY INFORMATION
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.
Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex,
if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan

Close

[H3]

[H1] Important Safety Information
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.
Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Repatha® is available as prefilled single-dose SureClick® autoinjectors and prefilled single-dose syringes that either contain dry natural rubber (a derivative of latex) in the needle cover or are not made with natural rubber latex. The carton and “Instructions for Use" in the carton will state if your prefilled single-dose SureClick® autoinjector or prefilled single-dose syringe contains dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.
Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.
What are the possible side effects of Repatha®?
Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.
The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or bruising at the injection site.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
[H3] APPROVED USE
What is Repatha®?
Repatha® is an injectable prescription medicine used:
to reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina) requiring hospitalization, or certain types of heart surgery, in adults at increased risk for these events.
Along with diet and exercise to reduce low-density lipoprotein (LDL) or bad cholesterol in adults with high blood cholesterol levels called hypercholesterolemia and in adults with a type of high cholesterol called heterozygous familial hypercholesterolemia (HeFH).
Please see full Prescribing Information, including Patient Product Information.

Open

[H5]

IMPORTANT SAFETY INFORMATION
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.
Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex,
if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan