Training Example: STRENSIQ (Alexion Pharmaceuticals, Inc.) – Review the Data, Give Your Score & Compare to the Real AI Evaluation

[IMG: hero-mobile]

KARA, CAREGIVER HPP STAR AND
QUINN,
WHO LIVES WITH HPP

[H3] Life with HPP
STRENSIQ® (asfotase alfa) is the first and only
prescription
medicine used to treat people with perinatal/infantile- and juvenile-onset
hypophosphatasia
(HPP).
Hear about the journey forward from people being treated with STRENSIQ.

[IMG: Jump Btn]

[IMG: hpp-dtc-lets-connect-left-button]

BACK

NEXT

[IMG: hpp-dtc-lets-connect-right-button]

[IMG: Jump Btn]

[H4] LET’S CONNECT

[H1] WHICH BEST DESCRIBES YOU?

[H2] (CHECK ALL THAT APPLY)

I think I (or someone I care about) could have HPP, but I don’t know the next steps.

I am a person living with or caring for someone with HPP, wanting to learn more
about
treatment.

I am a person living with or caring for someone with HPP, currently receiving
treatment
with STRENSIQ.

Talk to someone either living with or caring for someone with HPP.

Listen to an HPP healthcare professional and a patient or caregiver talk about the
condition.

Talk to someone either living with or caring for someone with HPP and
treating
with STRENSIQ.

Learn more about what I can expect with STRENSIQ.

Listen to an HPP healthcare professional and a patient or caregiver talk about
STRENSIQ.

Learn more about starting or administering STRENSIQ.

Talk to someone either living with or caring for someone with HPP and treating with
STRENSIQ.

Listen to an HPP healthcare professional and a patient or caregiver talk about
STRENSIQ.

Learn more about what I can expect with STRENSIQ.

Receive guidance on administering STRENSIQ.

[H3] Want information about HPP?

[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] Attend an HPP
Educational
Event

Register to attend an
educational, no-cost HPP
webinar
and/or live event. You’ll hear from someone whose life has been
impacted by HPP, as
well as
a
healthcare provider specializing in HPP.
Register
now

[IMG: square-item]

[H4] Sign up for our Peer
Connects program to talk to
someone impacted by HPP

Peer Connects is a phone-based program
that
matches you with an
HPP STAR who will share their story with you and can answer
questions
about HPP.

[IMG: square-item]

[H4] Connect with
OneSource™
OneSource™ is a complimentary,
personalized
patient support
program offered by Alexion. When you enroll in the program, you’ll
work
with a dedicated team
of people with expertise in rare conditions and health insurance.

[IMG: square-item]

[H4] REQUEST A STARTER KIT
Coping with HP

Hypophosphatasia (HPP) is often misdiagnosed as other conditions. But
the
more physicians out
there, the more parents out there that are aware of the symptoms,
they
can ask about it and
potentially get a correct diagnosis quicker than they otherwise
would.”
Becky, Caregiver HPP STAR

We all have our challenges, and HPP is mine. If I can help someone
else
because of my
experiences, I am grateful.”
Sharon, HPP STAR

I think the Peer Connects program is a nice way to communicate with
patients on a one-on-one
basis, hear their story, share our story, and really just help
people
through their
diagnosis.”
Becky, Caregiver HPP STAR

[IMG: Becky]

Hypophosphatasia (HPP) is often misdiagnosed as other
conditions. But the
more physicians out there, the more parents out there that are
aware
of the
symptoms, they can ask about it and potentially get a correct
diagnosis quicker than
they otherwise would.”
Becky, Caregiver HPP Star

OPTION 1

[H3] Want information about HPP?

[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] Sign up for our Peer Connects program
to
talk to
someone impacted by HPP

Peer Connects is a phone-based program
that
matches you
with an HPP STAR who will share their story with you and can answer
questions
about HPP.
Fill out the form below to connect with an HPP
STAR.

[IMG: Becky]

We believe that telling our story helps to facilitate hope
in
others.”
Dave, HPP STAR and Sharon, Caregiver HPP STAR

OPTION 2

[H3] Want information about HPP?

[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] Attend an HPP Educational Event

Register to attend an educational,
no-cost HPP webinar and/or live event. You’ll hear from someone whose life has been impacted
by HPP, as well as a healthcare provider specializing in HPP.
Register
now

[IMG: Sharon]

We all have our challenges, and HPP is mine. If I can help
someone else
because of my experiences, I am grateful.”
Sharon, HPP STAR

OPTION 1

[H3] WANT INFORMATION ABOUT STARTING TREATMENT
WITH
STRENSIQ?
[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] Sign up for our Peer Connects program
to
talk to
someone impacted by HPP

Peer Connects is a phone-based program
that
matches you
with an HPP STAR who will share their story with you and can answer
questions
about HPP.
Fill out the form below to connect with an HPP
STAR.

[IMG: Sharon]

In connecting with OneSource™, I got such great information.
They helped me
with my insurance, they helped me with my questions. If they didn’t
have the answers,
they helped me find them. There’s always wonderful people on the
other end of the
line
that make me feel as though I’m not alone in this.”
Sharon, HPP STAR

OPTION 2

[H3] WANT INFORMATION ABOUT STARTING TREATMENT
WITH
STRENSIQ?
[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] CONNECT WITH ONESOURCE™

OneSource™ is a complimentary,
personalized
patient
support program offered by Alexion. When you enroll in the program, you’ll
work with a
dedicated team of people with expertise in rare conditions and health
insurance.
Fill out the form below to get in touch with a
OneSource™
team
member.

[IMG: Becky]

We believe that telling our story helps to facilitate hope
in
others.”
Dave, HPP STAR and Sharon, Caregiver HPP STAR

OPTION 3

[H3] WANT INFORMATION ABOUT STARTING TREATMENT
WITH
STRENSIQ?
[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] Attend an HPP Educational Event

Register to attend an educational,
no-cost
HPP webinar
and/or live event. You’ll hear from someone whose life has been impacted
by
HPP, as well as
a
healthcare provider specializing in HPP.
Register
now

[IMG: Becky]

When we decided that Juliana was going to take STRENSIQ,
and
that we had to
deliver it by injection, I think I was more nervous than Juliana was.
We were trained
at the doctor’s office, and I administered that first injection and
Juliana didn’t
bat
an eyelash.”
Becky, Caregiver HPP STAR and Juliana, who lives with
HPP

OPTION 4

[H3] WANT INFORMATION ABOUT STARTING TREATMENT
WITH
STRENSIQ?
[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] REQUEST A STARTER KIT

Coping with HPP can be difficult but
administering
treatment
shouldn’t have to be. The STRENSIQ Patient Starter Kit is equipped with
tools
to help
familiarize you with STRENSIQ.
Fill out the form below to request a STRENSIQ
Patient
Starter Kit.

[IMG: Becky]

I think the Peer Connects program is a nice way to
communicate
with
patients on a one-on-one basis, hear their story, share our
story,
and really just
help
people through their diagnosis.”
Becky, Caregiver HPP STAR

OPTION 1

[H3] WANT SUPPORT AND INFORMATION FOR HPP AND
STRENSIQ?

[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] SIGN UP FOR OUR PEER CONNECTS PROGRAM
TO
TALK TO
SOMEONE IMPACTED BY HPP

Peer Connects is a phone-based program
that
matches you
with an HPP STAR who will share their story with you and can answer
questions
about HPP.
Fill out the form below to connect with an HPP
STAR.

[IMG: Sharon]

It’s just so important to have human connection. You can
learn
about the
disease, you can read about it on the internet, but to actually talk
to
people who
are
educated about it and can guide you and comfort you is really so
important.”
Sharon, HPP STAR

OPTION 2

[H3] WANT SUPPORT AND INFORMATION FOR HPP AND
STRENSIQ?

[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] ATTEND AN HPP EDUCATIONAL EVENT

Register to attend an educational,
no-cost
HPP webinar
and/or live event. You’ll hear from someone whose life has been impacted
by
HPP, as well as
a
healthcare provider specializing in HPP.
Register
now

[IMG: Ray]

The case manager was great and asked a lot of great questions.
It really
gave
me that opportunity to talk to somebody who knew what hypophosphatasia
was.”
Ray, HPP STAR

OPTION 3

[H3] WANT SUPPORT AND INFORMATION FOR HPP AND
STRENSIQ?

[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] CONNECT WITH ONESOURCE™

OneSource™ is a complimentary,
personalized
patient
support program offered by Alexion. When you enroll in the program, you’ll
work with a
dedicated team of people with expertise in rare conditions and health
insurance.
Fill out the form below to learn more about our
webinar and/or
live HPP educational events.

[IMG: Becky]

When we decided that Juliana was going to take STRENSIQ,
and
that we had to
deliver it by injection, I think I was more nervous than Juliana was.
We were trained
at the doctor’s office, and I administered that first injection and
Juliana didn’t
bat
an eyelash.”
Becky, Caregiver HPP STAR and Juliana, who lives with
HPP

OPTION 4

[H3] WANT SUPPORT AND INFORMATION FOR HPP AND
STRENSIQ?

[H2] We recommend THAT YOU…

[IMG: square-item]

[H4] REQUEST A STARTER KIT

Coping with HPP can be difficult but
administering
treatment
shouldn’t have to be. The STRENSIQ Patient Starter Kit is equipped with
tools
to help
familiarize you with STRENSIQ.
Fill out the form below to request a STRENSIQ
Patient
Starter Kit.

[IMG: getting-started]

[H3] HPP Support
Explore support options, find
helpful
downloads, and meet other people living with HPP.
HPP
Resources

[IMG: life-with-strensiq]

[H3] courage TO USE Strensiq
STRENSIQ is an injectable
prescription
medication you can take at home as part of your routine.
HOW
TO USE STRENSIQ

[IMG: life-with]

[H2] Life with strensiq
When I think about the
journey that
Quinn has been
on
and continues on, I see him finding his sense of independence—every day, every week,
every year.”
Kara, Caregiver HPP STAR

What is the most important information I should know about STRENSIQ® (asfotase alfa)?

STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
difficulty breathing
choking sensation
swelling of your eyes, lips, or tongue
dizziness
nausea or vomiting
fever
headache
sweating
feeling irritable
chills
skin redness
skin rash or hives
itching or numbness of the tongue, lips, cheeks,
or gums

What are the other possible side effects of STRENSIQ?

STRENSIQ may cause other serious side effects, including:

skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if you:

have had an allergic reaction to STRENSIQ.

are pregnant or plan to become pregnant. It is not
known
if STRENSIQ will harm your unborn baby.

are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider
about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.

There is a registry for people who use STRENSIQ. The
purpose of this registry is to collect information about HPP and about what
happens
when
you use STRENSIQ for a long time. For more information
about this
registry, talk with your healthcare provider or go
to www.hppregistry.com

To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at 1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/medwatch.

INDICATION

What is STRENSIQ?

STRENSIQ® (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).

Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic
(hypersensitivity) reaction.

What is the most important information I should know about STRENSIQ® (asfotase alfa)?

STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any

[H2] Juliana, Living with HPP

Attend a free webinar or in-person event to learn more about hypophosphatasia (HPP) and
STRENSIQ® (asfotase alfa) from healthcare professionals experienced in HPP, hear from
people living with or caring for someone with HPP, and connect with others impacted by
HPP.

jan
23

next event
Talk about HPP

City, State
6:00 PM EST
Presented by:
Alexion Pharmaceuticals, Inc.

Register

[H1] Upcoming Events

STRENSIQ is a prescription medicine used to treat people with perinatal/infantile- and
juvenile-onset
hypophosphatasia (HPP).
Please note that these programs are intended for US patients and caregivers only. For
information on
Alexion programs for healthcare professionals, please visit https://strensiq-hcp.com.

All
In-Person
Virtual

jan
24

Talk Title 2

City, State
5:00 PM EST
Presented by: Alexion Pharmaceuticals, Inc.

Presented by: Alexion Pharmaceuticals, Inc.

Register

About

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Venue information

Venue Name
Address
City, State Zip Code

About

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Venue
Address
City, State Zip Code

Becky, caregiver hpp star and
Juliana, who lives with HPP

[H3] StartING STRENSIQ with courage

Coping with hypophosphatasia (HPP) can be difficult, but starting treatment
shouldn’t have to
be. The STRENSIQ Patient Starter Kit is equipped with tools to help familiarize you with
STRENSIQ®
(asfotase alfa).

[IMG: Jump Btn]

REQUEST A STARTER Kit

WHAT’S INSIDE
HOW TO REQUEST

[H2] What’s in the strensiq
Patient
starter
kit?

[IMG: Starter Kit]

STRENSIQ patient
brochure
SYMPTOM TRACKER AND
LOG
US
PRESCRIBING INFORMATION
WELCOME LETTER

PATIENT EDUCATION
EVENT CARD
OneSource™
BROCHURE
MEDICAL ALERT
CARD
FACEBOOK CARD

×

STRENSIQ Patient Brochure
Detailed information on how STRENSIQ works
and what
to
expect while
taking treatment

Symptom Tracker and Log
A journal to help track symptoms and prepare
for
doctor’s visits

US Prescribing Information
Complete safety and efficacy information
about
STRENSIQ

Welcome Letter
An overview of OneSource™ and what’s
included in
your
STRENSIQ Patient
Starter Kit

Patient Education Event Card
Information about HPP educational programs
for
patients
and caregivers

OneSource™ Brochure
An overview of services provided by
OneSource™

Medical Alert Card
A wallet-sized card to help inform emergency
room
staff,
doctors, or
care providers of your condition and STRENSIQ’s effects on your labs

Facebook Card
Information about how to join and connect
with
STRENSIQ’s online
communities

[IMG: contact image]

As you review these materials,
remember that you
can always talk with a OneSource™ Case Manager at 1.888.765.4747 or email
OneSource@alexion.com.

[IMG: Video for tips]

[H3] GETTING STARTED ON STRENSIQ

Hear others talk about starting and staying on STRENSIQ.

[H2] LOOKING FOR HPP SUPPORT?

In the STRENSIQ Patient Starter Kit, you’ll
find
helpful information about beginning treatment. Learn about more resources available to
people
living with
HPP and their loved ones.
RESOURCES

What is the most important information I should know about STRENSIQ® (asfotase alfa)?

STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
difficulty breathing
choking sensation
swelling of your eyes, lips, or tongue
dizziness
nausea or vomiting
fever
headache
sweating
feeling irritable
chills
skin redness
skin rash or hives
itching or numbness of the tongue, lips, cheeks,
or gums

What are the other possible side effects of STRENSIQ?

STRENSIQ may cause other serious side effects, including:

skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if you:

have had an allergic reaction to STRENSIQ.

are pregnant or plan to become pregnant. It is not
known
if STRENSIQ will harm your unborn baby.

are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider
about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.

There is a registry for people who use STRENSIQ. The
purpose of this registry is to collect information about HPP and about what
happens
when
you use STRENSIQ for a long time. For more information
about this
registry, talk with your healthcare provider or go
to www.hppregistry.com

To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at 1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/medwatch.

INDICATION

What is STRENSIQ?

STRENSIQ® (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).

Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic
(hypersensitivity) reaction.

What is the most important information I should know about STRENSIQ® (asfotase alfa)?

STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
difficulty breathing
choking sensation
swelling of your eyes, lips, or tongue
dizziness
nausea or vomiting
fever
headache
sweating
feeling irritable
chills
skin redness
skin rash or hives
itching or numbness of the tongue, lips, cheeks,
or gums

What are the other possible side effects of STRENSIQ?

STRENSIQ may cause other serious side effects, including:

skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if you:

have had an allergic reaction to STRENSIQ.

are pregnant or plan to become pregnant. It is not
known
if STRENSIQ will harm your unborn baby.

are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider
about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.

There is a registry for people who use STRENSIQ. The
purpose of this registry is to collect information about HPP and about what
happens
when
you use STRENSIQ for a long time. For more information
about this
registry, talk with your healthcare provider or go
to www.hppregistry.com

To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at 1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/medwatch.

INDICATION

What is STRENSIQ?

STRENSIQ (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).

Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic
(hypersensitivity) reaction.

KARA, CAREGIVER HPP STAR AND QUINN, WHO
LIVES WITH HPP

[H3] live with confidence
STRENSIQ® (asfotase alfa) is an injection given under the
skin
(called a subcutaneous injection) and can be conveniently taken at home or wherever you
go.

Hear how people learned to inject STRENSIQ with confidence.

[IMG: Jump Btn]

HOW TO USE STRENSIQ

HOW IT’S DOSED
INJECTION TIPS
RESOURCES
SELF-INJECTION

[H2] HOW STRENSIQ IS DOSED
STRENSIQ is dosed in milligrams based on weight. You and your doctor will decide which
dosage
and
treatment schedule are right for you. As your weight changes, your dosage may also
change
depending on
your doctor’s recommendations.

STRENSIQ is dosed as either:

It is important to use STRENSIQ as described in
the
Patient Prescribing Information and Instructions
for Use, or as instructed by your doctor, nurse, and/or pharmacist.

[H3] Strensiq Injection How-To

HPP STARs share how to properly inject STRENSIQ.

[H2] PREPARING FOR SELF-INJECTION
Some people with hypophosphatasia (HPP) may feel like the
condition takes
away their independence.
Self-injecting STRENSIQ can take back
some
of this lost independence.
Controlling injections can be empowering for some people, but it can also seem like a
scary
step to
take. To prepare for self-injections, consider the following ideas:

[H5] Ask questions
If your doctor decides you or someone you care for is ready to self-inject
STRENSIQ, do not
hesitate to ask questions. It is important to ensure everyone involved is
comfortable making this
transition.

[H5] Set a routine
Establishing a routine can help someone adapt to remembering their
injections.
For example, some
may prefer to inject in the morning before eating breakfast, while others
may
wish to inject at
night before going to bed.

[H5] Monitor at first
It may also be beneficial for a caregiver to monitor the first few
self-injections. Having
someone who is familiar with the injection process may relieve some anxiety
about self-injecting.

[H3]
Record important HPP information on a medical
alert card.
In
the event of an emergency, this card can quickly communicate your condition and
specific
needs to
medical personnel.

[IMG: life-with]

[H2] OUR STRENSIQ ROUTINE
Quinn
and I
have our STRENSIQ routine. He retrieves
the vials while I prepare syringes and supplies. Depending upon the site, either he
or I
do the
injection.”
Kara, Caregiver HPP STAR

[H2] TIPS FOR SMOOTH INJECTION

Whether you are injecting
STRENSIQ
into yourself
or someone
you care for, it’s normal to feel anxious.
An important part of the process
is
for you to
feel
confident injecting STRENSIQ. If you need anything clarified about injection, don’t
be
afraid to ask
questions or have your doctor review something more than once.

STRENSIQ can be injected under the
skin
of the stomach
area, upper arms, upper legs, or buttocks.
STRENSIQ should not be injected into
the
buttocks for
infants.

Choose a different area each time
you
inject to help
avoid irritation at the injection site.

Do not inject STRENSIQ into skin
that is
red, hot, or
swollen.

STRENSIQ may cause serious side effects, including serious allergic
(hypersensitivity)
reactions and
skin thickening or pits at the injection site (lipodystrophy).

[H5] Recommended injection sites
Speak with your nurse, doctor, and/or pharmacist for more information on where to
inject STRENSIQ.

STRENSIQ may cause serious side effects, including serious allergic (hypersensitivity)
reactions and
skin thickening or pits at the injection site (lipodystrophy).

[H2] RESOURCES FOR INJECTION-SITE REACTIONS
(ISRs)

You may experience ISRs, which are painful,
itchy, or swollen
skin after injecting
STRENSIQ® (asfotase alfa). A local skin injection-site reaction
is
one of the most
common side effects of STRENSIQ.

You may experience ISRs, which are painful, itchy, or swollen skin after
injecting
STRENSIQ® (asfotase alfa). A local skin injection-site reaction
is
one of the most
common side effects of STRENSIQ.

[H5] ISRs may appear as:

Red skin patches
Bruising
Color change
Pain
Itching

Thinning
Swelling
Pits
Bumps
Hardening/thickening of the skin

DOWNLOAD ISR BROCHURE

[H3] WHAT TO DO IF YOU EXPERIENCE AN ISR
It may help to take a photo of the injection-site reaction(s) to show
your
or your loved
one’s
doctor.
You can also describe it using these prompts:
Where is the reaction?
What does it feel like?
How soon after an injection do you notice it?
How large is it?
How long does it typically last before going away?

[H3] MANAGING ISRs
While these reactions may be temporarily unpleasant, in most cases, they
can
be
manageable and may
resolve within a week. If you experience an ISR, OneSource™ is here for you.
Visit OneSource™ or call
1.888.765.4747 for
additional information
and support.
If you experience an ISR, you should discuss it with your doctor. OneSource is
not a
substitute
for medical advice.

[H3] WHAT TO DO IF YOU EXPERIENCE AN ISR
It may help to take a photo of the injection-site reaction(s) to show your or your
loved
one’s
doctor.
You can also describe it using these prompts:
Where is the reaction?
What does it feel like?
How soon after an injection do you notice it?
How large is it?
How long does it typically last before going away?

[H3] MANAGING ISRs
While these reactions may be temporarily unpleasant, in most cases, they can be
manageable and
may resolve
within a week. If you experience an ISR, OneSource™ is here for you.
Visit OneSource™ or call 1.888.765.4747 for
additional
information
and support.
If you experience an ISR, you should discuss it with your doctor. OneSource is not a
substitute
for
medical advice.

[H2] STRENSIQ INJECTION RESOURCES

[H5] Injection starter kit

In your first shipment of STRENSIQ, you will receive an injection starter kit.
This
kit provides an
injection supply mat, injection site tracker and calendar, and other tools that
will
help establish
a routine with STRENSIQ.

[H5] Injection IQ

Read a complete guide on injecting STRENSIQ into yourself or someone you care
for.

DOWNLOAD GUIDE

[H3]
OneSource™ Case Managers are always available to talk through questions or
concerns about
injections. Reach out at 1.888.765.4747, OneSource@alexion.com, or AlexionOneSource.com.

[H3] FINDING INJECTION COURAGE

Caregiver HPP STAR Kara and her son Quinn learn to inject STRENSIQ with confidence.

[H2] LOOKING FOR MORE STRENSIQ TIPS?
It’s normal to feel uneasy about
fitting
STRENSIQ
into your routine. Check out more tips to help you feel confident as you begin and
continue
treatment.
TIPS FOR
USING
STRENSIQ

What is the most important information I should know about STRENSIQ® (asfotase alfa)?

STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
difficulty breathing
choking sensation
swelling of your eyes, lips, or tongue
dizziness
nausea or vomiting
fever
headache
sweating
feeling irritable
chills
skin redness
skin rash or hives
itching or numbness of the tongue, lips, cheeks,
or gums

What are the other possible side effects of STRENSIQ?

STRENSIQ may cause other serious side effects, including:

skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if you:

have had an allergic reaction to STRENSIQ.

are pregnant or plan to become pregnant. It is not
known
if STRENSIQ will harm your unborn baby.

are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider
about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.

There is a registry for people who use STRENSIQ. The
purpose of this registry is to collect information about HPP and about what
happens
when
you use STRENSIQ for a long time. For more information
about this
registry, talk with your healthcare provider or go
to www.hppregistry.com

To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at 1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/medwatch.

INDICATION

What is STRENSIQ?

STRENSIQ® (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).

Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic
(hypersensitivity) reaction.

What is the most important information I should know about STRENSIQ® (asfotase alfa)?

STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
difficulty breathing
choking sensation
swelling of your eyes, lips, or tongue
dizziness
nausea or vomiting
fever
headache
sweating
feeling irritable
chills
skin redness
skin rash or hives
itching or numbness of the tongue, lips, cheeks,
or gums

What are the other possible side effects of STRENSIQ?

STRENSIQ may cause other serious side effects, including:

skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if you:

have had an allergic reaction to STRENSIQ.

are pregnant or plan to become pregnant. It is not
known
if STRENSIQ will harm your unborn baby.

are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider
about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.

There is a registry for people who use STRENSIQ. The
purpose of this registry is to collect information about HPP and about what
happens
when
you use STRENSIQ for a long time. For more information
about this
registry, talk with your healthcare provider or go
to www.hppregistry.com

To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at 1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/medwatch.

INDICATION

What is STRENSIQ?

STRENSIQ (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).

Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic
(hypersensitivity) reaction.